Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction.
J Neural Transm (Vienna)
; 122(6): 741-6, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25261015
The aim of this study was to elucidate whether glutathione is involved in lithium's ability to decrease carbonylation and nitration produced by complex I inhibition, which is consistently found in BD. Neuroblastoma cells were treated with rotenone, a complex I inhibitor. Our results suggest that glutathione is essential for lithium's ability to ameliorate rotenone-induced protein carbonylation, but not nitration.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tirosina
/
Compostos de Lítio
/
Complexo I de Transporte de Elétrons
/
Carbonilação Proteica
/
Glutationa
Limite:
Humans
Idioma:
En
Revista:
J Neural Transm (Vienna)
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Áustria