RESUMO
Introdução: Nos últimos anos, a prevalência de feridas crônicas tem aumentado devido ao crescimento da expectativa de vida, ao aumento das doenças crônicas e das comorbidades. O fisioterapeuta desempenha um papel importante no processo de cicatrização destas feridas, através de recursos capazes de acelerar o reparo tecidual, em destaque à ozonioterapia. O ozônio age como agente terapêutico, proporcionando benefícios à restauração tecidual, além do efeito antimicrobiano, bactericida e fungicida. Objetivo: Verificar o efeito da ozonioterapia na cicatrização de uma ferida crônica em um paciente com diabetes mellitus. Métodos: O participante foi submetido a uma avaliação e a coleta de material microbiológico antes e após o tratamento com ozônio. Foram realizadas 15 sessões de ozonioterapia, que ocorreram três vezes por semana com uma duração de 10 minutos. Resultados: No presente estudo foi encontrada a bactéria multirresistente Pseudomonas aeruginosa e obteve-se uma redução de 99% de unidades formadoras de colônias e houve uma diminuição de 45,5cm² da lesão tecidual. Conclusão: O processo de cicatrização foi quantificado pela área total da lesão tratada e, neste aspecto, a ozonioterapia demonstrou um resultado positivo, acarretando a redução da ferida. No entanto, o número de amostra foi insuficiente para obter um resultado estatisticamente significativo. (AU)
Introduction: In recent years, the prevalence of chronic wounds has increased due to an increase in life expectancy, chronic diseases and comorbidities. The physiotherapist plays an important role in the healing process of these wounds, through resources capable of accelerating tissue repair, like ozone therapy. Ozone acts as a therapeutic agent, providing benefits to the tissue restoration, besides the antimicrobial, bactericidal and fungicidal effect. Objective: To verify the effect of ozonotherapy in the healing of a chronic wound in a patient with diabetes mellitus. Methods: The participant was submitted to an evaluation and the collection of microbiological material before and after treatment with ozone. Fifteen sessions of ozonotherapy were performed, which occurred three times a week with a duration of 10 minutes. Results: In the present study the multiresistant bacterium Pseudomonas aeruginosa was detected, and a 99% reduction of colony units was obtained with a reduction of 45.5 cm² of the tissue lesion. Conclusion: The healing process was quantified by the total area of the treated lesion and, in this aspect, ozonotherapy showed a positive result, leading to reduction of the wound. However, the sample number was insufficient to obtain a statistically significant result. (AU)
Assuntos
Ozônio , Cicatrização , Ferimentos e Lesões , Modalidades de FisioterapiaRESUMO
Obesity is a major public health problem worldwide. It has a complex etiology, influenced by environmental and genetic factors. FTO has been recognized as an important genetic factor for obesity development. This study evaluated the contribution of FTO polymorphisms (rs9939609 and rs17817449) for extreme obesity in terms of the period of obesity onset, anthropometric, and biochemical parameters. The haplotype and the combined effects of FTO risk alleles on obesity susceptibility were evaluated. We investigated 169 normal-weight subjects (body mass index, BMI: 22.8 [21.0; 24.0] kg/m2) and 123 extremely obese individuals (BMI: 47.6 [44.1; 53.1] kg/m2). Genotyping was performed by real time PCR. Our results showed a strong association between FTO variants and extreme obesity. Carriers of the AT haplotype had an increased risk for extreme obesity. Gene scores suggested that the risk of developing extreme obesity was increased 1.37-fold per risk allele added. Both polymorphisms also influenced BMI and body weight. Additionally, rs17817449 influenced triglyceride levels. No effect of FTO variants on the period of obesity onset was found. In conclusion, the FTO polymorphisms showed a strong association with development of extreme phenotype of obesity and adiposity modulation in a Brazilian population.