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Genetic variants in the fat mass and obesity-associated (FTO) gene confer risk for extreme obesity and modulate adiposity in a Brazilian population.
Fonseca, Ana Carolina Proença da; Marchesini, Bruna; Zembrzuski, Verônica Marques; Voigt, Danielle Dutra; Ramos, Vivianne Galante; Carneiro, João Regis Ivar; Nogueira Neto, José Firmino; Cabello, Giselda Maria Kalil de; Cabello, Pedro Hernán.
Afiliação
  • Fonseca ACPD; Instituto Oswaldo Cruz (FIOCRUZ), Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
  • Marchesini B; Instituto Oswaldo Cruz (FIOCRUZ), Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
  • Zembrzuski VM; Instituto Oswaldo Cruz (FIOCRUZ), Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
  • Voigt DD; Universidade do Grande Rio, Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
  • Ramos VG; Universidade do Grande Rio, Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
  • Carneiro JRI; Universidade Federal do Rio de Janeiro, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil.
  • Nogueira Neto JF; Universidade do Estado do Rio de Janeiro, Departamento de Patologia, Rio de Janeiro, RJ, Brazil.
  • Cabello GMK; Instituto Oswaldo Cruz (FIOCRUZ), Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
  • Cabello PH; Instituto Oswaldo Cruz (FIOCRUZ), Laboratório de Genética Humana, Rio de Janeiro, RJ, Brazil.
Genet Mol Biol ; 43(1): e20180264, 2020.
Article em En | MEDLINE | ID: mdl-32154826
Obesity is a major public health problem worldwide. It has a complex etiology, influenced by environmental and genetic factors. FTO has been recognized as an important genetic factor for obesity development. This study evaluated the contribution of FTO polymorphisms (rs9939609 and rs17817449) for extreme obesity in terms of the period of obesity onset, anthropometric, and biochemical parameters. The haplotype and the combined effects of FTO risk alleles on obesity susceptibility were evaluated. We investigated 169 normal-weight subjects (body mass index, BMI: 22.8 [21.0; 24.0] kg/m2) and 123 extremely obese individuals (BMI: 47.6 [44.1; 53.1] kg/m2). Genotyping was performed by real time PCR. Our results showed a strong association between FTO variants and extreme obesity. Carriers of the AT haplotype had an increased risk for extreme obesity. Gene scores suggested that the risk of developing extreme obesity was increased 1.37-fold per risk allele added. Both polymorphisms also influenced BMI and body weight. Additionally, rs17817449 influenced triglyceride levels. No effect of FTO variants on the period of obesity onset was found. In conclusion, the FTO polymorphisms showed a strong association with development of extreme phenotype of obesity and adiposity modulation in a Brazilian population.

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Genet Mol Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Etiology_studies / Risk_factors_studies País/Região como assunto: America do sul / Brasil Idioma: En Revista: Genet Mol Biol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Brasil País de publicação: Brasil