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1.
An Bras Dermatol ; 95(2): 180-186, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32146010

RESUMO

BACKGROUND: Lichen planus is a chronic inflammatory mucocutaneous disease. Recent studies have suggested that it is associated with an increased risk of cardiovascular comorbidities. OBJECTIVE: The purpose of this study was to assess and compare arterial stiffness and cardiovascular hemodynamics in patients with lichen planus and a healthy control group. METHODS: Fifty-five patients with lichen planus and 42 healthy controls were enrolled. All patients underwent echocardiographic examination, and arterial stiffness was measured using applanation tonometry. RESULTS: No statistically significant difference was determined between the patient and control groups in terms of arterial stiffness, but stiffness was markedly higher in patients with erosive lichen planus compared to the control group and other patients (p=0.006, and p=0.023, respectively). Moderate positive correlation was determined between duration of disease and arterial stiffness. Impairment of systolic and diastolic functions was also determined in patients with lichen planus compared to the control group (p<0.001, and p=0.005, respectively). STUDY LIMITATIONS: Relatively low number of patients. CONCLUSION: The positive correlation observed between duration of disease and arterial stiffness in patients with lichen planus suggests that these patients should be followed-up in terms of cardiovascular risk in the presence of resistant and long-term disease, particularly in case of erosive lichen planus.


Assuntos
Doenças Cardiovasculares/fisiopatologia , Hemodinâmica/fisiologia , Líquen Plano/fisiopatologia , Rigidez Vascular/fisiologia , Adulto , Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/etiologia , Estudos de Casos e Controles , Ecocardiografia , Feminino , Coração/fisiopatologia , Humanos , Líquen Plano/complicações , Modelos Lineares , Masculino , Manometria/métodos , Pessoa de Meia-Idade , Valores de Referência , Estatísticas não Paramétricas , Fatores de Tempo
2.
An. bras. dermatol ; An. bras. dermatol;95(2): 180-186, Mar.-Apr. 2020. tab, graf
Artigo em Inglês | LILACS, Coleciona SUS | ID: biblio-1130838

RESUMO

Abstract Background: Lichen planus is a chronic inflammatory mucocutaneous disease. Recent studies have suggested that it is associated with an increased risk of cardiovascular comorbidities. Objective: The purpose of this study was to assess and compare arterial stiffness and cardiovascular hemodynamics in patients with lichen planus and a healthy control group. Methods: Fifty-five patients with lichen planus and 42 healthy controls were enrolled. All patients underwent echocardiographic examination, and arterial stiffness was measured using applanation tonometry. Results: No statistically significant difference was determined between the patient and control groups in terms of arterial stiffness, but stiffness was markedly higher in patients with erosive lichen planus compared to the control group and other patients (p = 0.006, and p = 0.023, respectively). Moderate positive correlation was determined between duration of disease and arterial stiffness. Impairment of systolic and diastolic functions was also determined in patients with lichen planus compared to the control group (p < 0.001, and p = 0.005, respectively). Study limitations: Relatively low number of patients. Conclusion: The positive correlation observed between duration of disease and arterial stiffness in patients with lichen planus suggests that these patients should be followed-up in terms of cardiovascular risk in the presence of resistant and long-term disease, particularly in case of erosive lichen planus.


Assuntos
Humanos , Masculino , Feminino , Adulto , Doenças Cardiovasculares/fisiopatologia , Rigidez Vascular/fisiologia , Hemodinâmica/fisiologia , Líquen Plano/fisiopatologia , Valores de Referência , Fatores de Tempo , Ecocardiografia , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/diagnóstico por imagem , Estudos de Casos e Controles , Modelos Lineares , Estatísticas não Paramétricas , Coração/fisiopatologia , Líquen Plano/complicações , Manometria/métodos , Pessoa de Meia-Idade
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