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1.
Braz J Med Biol Res ; 53(7): e9628, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32520209

RESUMO

Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear. The present study was performed to investigate the protective effect of OP-D in the STZ-induced DN rat model. DN rats showed renal dysfunction, as evidenced by decreased serum albumin and creatinine clearance, along with increases in serum creatinine, blood urea nitrogen, TGF-ß1, and kidney hypertrophy, and these were reversed by OP-D. In addition, STZ induced oxidative damage and inflammatory response in diabetic kidney tissue. These abnormalities were reversed by OP-D treatment. The findings obtained in the present study indicated that OP-D might possess the potential to be a therapeutic agent against DN via inhibiting renal inflammation and oxidative stress.


Assuntos
Diabetes Mellitus Experimental/tratamento farmacológico , Nefropatias Diabéticas/tratamento farmacológico , Inflamação/prevenção & controle , Ophiopogon/química , Estresse Oxidativo/efeitos dos fármacos , Saponinas/uso terapêutico , Espirostanos/uso terapêutico , Animais , Masculino , Ratos , Ratos Sprague-Dawley , Estreptozocina
2.
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;53(7): e9628, 2020. tab, graf
Artigo em Inglês | LILACS, Coleciona SUS | ID: biblio-1132530

RESUMO

Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear. The present study was performed to investigate the protective effect of OP-D in the STZ-induced DN rat model. DN rats showed renal dysfunction, as evidenced by decreased serum albumin and creatinine clearance, along with increases in serum creatinine, blood urea nitrogen, TGF-β1, and kidney hypertrophy, and these were reversed by OP-D. In addition, STZ induced oxidative damage and inflammatory response in diabetic kidney tissue. These abnormalities were reversed by OP-D treatment. The findings obtained in the present study indicated that OP-D might possess the potential to be a therapeutic agent against DN via inhibiting renal inflammation and oxidative stress.


Assuntos
Animais , Masculino , Ratos , Saponinas/uso terapêutico , Estresse Oxidativo/efeitos dos fármacos , Ophiopogon/química , Diabetes Mellitus Experimental/tratamento farmacológico , Nefropatias Diabéticas/tratamento farmacológico , Inflamação/prevenção & controle , Espirostanos/uso terapêutico , Ratos Sprague-Dawley , Estreptozocina
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