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Ophiopogonin D of Ophiopogon japonicus ameliorates renal function by suppressing oxidative stress and inflammatory response in streptozotocin-induced diabetic nephropathy rats
Qiao, Yanhong; Jiao, Haiyan; Wang, Feng; Niu, Huimin.
Afiliação
  • Qiao, Yanhong; Heping Hospital affiliated to Changzhi Medical College. Nephrology Department. Changzhi. CN
  • Jiao, Haiyan; Heping Hospital affiliated to Changzhi Medical College. Nephrology Department. Changzhi. CN
  • Wang, Feng; Heping Hospital affiliated to Changzhi Medical College. Nephrology Department. Changzhi. CN
  • Niu, Huimin; Heping Hospital affiliated to Changzhi Medical College. Nephrology Department. Changzhi. CN
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;53(7): e9628, 2020. tab, graf
Article em En | LILACS, ColecionaSUS | ID: biblio-1132530
Biblioteca responsável: BR1.1
ABSTRACT
Ophiopogonin D (OP-D) is the principal pharmacologically active ingredient from Ophiopogon japonicas, which has been demonstrated to have numerous pharmacological activities. However, its protective effect against renal damage in streptozotocin (STZ)-induced diabetic nephropathy (DN) rats remains unclear. The present study was performed to investigate the protective effect of OP-D in the STZ-induced DN rat model. DN rats showed renal dysfunction, as evidenced by decreased serum albumin and creatinine clearance, along with increases in serum creatinine, blood urea nitrogen, TGF-β1, and kidney hypertrophy, and these were reversed by OP-D. In addition, STZ induced oxidative damage and inflammatory response in diabetic kidney tissue. These abnormalities were reversed by OP-D treatment. The findings obtained in the present study indicated that OP-D might possess the potential to be a therapeutic agent against DN via inhibiting renal inflammation and oxidative stress.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / ColecionaSUS Assunto principal: Saponinas / Estresse Oxidativo / Ophiopogon / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Brasil

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS / ColecionaSUS Assunto principal: Saponinas / Estresse Oxidativo / Ophiopogon / Diabetes Mellitus Experimental / Nefropatias Diabéticas / Inflamação Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Assunto da revista: BIOLOGIA / MEDICINA Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China País de publicação: Brasil