RESUMO
To determine the ability of monocyte phagosomal acidification in chronic paracoccidioidomycosis, 13 patients were recruited at different times during follow-up and compared with 18 normal controls. Eight patients were studied at diagnosis, six of them also during treatment and five additional patients after ending treatment. Phagosomal acidification of monocytes, triggered by challenge with opsonized zymosan, was evaluated with acridine orange and expressed as percentage of orange-stained intracellular particles, as mean +/- SE. In comparison with controls, acidification was severely impaired before treatment (33 +/- 11% vs. 67 +/- 6%) and reached values similar to controls during treatment (73 +/- 6%, n = 6). In addition, phagosomal acidification of the patients studied after treatment (63 +/- 4%) had no difference when compared with controls. This study demonstrates that phagosomal acidification is perturbed among chronic paracoccidioidomycosis patients and reverses with antifungal treatment.
Assuntos
Monócitos/metabolismo , Paracoccidioidomicose/imunologia , Fagossomos/metabolismo , Laranja de Acridina/metabolismo , Adulto , Antifúngicos/uso terapêutico , Células Cultivadas , Humanos , Concentração de Íons de Hidrogênio , Masculino , Microscopia de Fluorescência/métodos , Pessoa de Meia-Idade , Monócitos/citologia , Paracoccidioidomicose/tratamento farmacológico , Zimosan/imunologia , Zimosan/metabolismoRESUMO
This short review address the concept of cytokine and cytokine families, their relationship with CNS, cytokine effects on nervous system (namely, sickness behavior) and the cellular source of brain cytokines. In addition, it provides selected data on the role of cytokines in mental disorders such as depression, schizophrenia, Alzheimer's disease and AIDS-related dementia.
Assuntos
Citocinas/imunologia , Transtornos Mentais/imunologia , Humanos , Receptores de Citocinas/imunologia , Papel do DoenteRESUMO
This short review address the concept of cytokine and cytokine families, their relationship with CNS, cytokine effects on nervous system (namely, sickness behavior) and the cellular source of brain cytokines. In addition, it provides selected data on the role of cytokines in mental disorders such as depression, schizophrenia, Alzheimers disease and AIDS-related dementia.
RESUMO
This short review address the concept of cytokine and cytokine families, their relationship with CNS, cytokine effects on nervous system (namely, sickness behavior) and the cellular source of brain cytokines. In addition, it provides selected data on the role of cytokines in mental disorders such as depression, schizophrenia, Alzheimers disease and AIDS-related dementia.