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Decreased monocytic phagosomal acidification among chronic paracoccidioidomycosis patients.
Guereño, M Teresa; Silaf, M Rosario; Bava, A Javier; Negroni, Ricardo; Diez, Roberto A.
Afiliação
  • Guereño MT; Laboratorio de Inmunofarmacología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Mycoses ; 46(9-10): 397-401, 2003.
Article em En | MEDLINE | ID: mdl-14622388
To determine the ability of monocyte phagosomal acidification in chronic paracoccidioidomycosis, 13 patients were recruited at different times during follow-up and compared with 18 normal controls. Eight patients were studied at diagnosis, six of them also during treatment and five additional patients after ending treatment. Phagosomal acidification of monocytes, triggered by challenge with opsonized zymosan, was evaluated with acridine orange and expressed as percentage of orange-stained intracellular particles, as mean +/- SE. In comparison with controls, acidification was severely impaired before treatment (33 +/- 11% vs. 67 +/- 6%) and reached values similar to controls during treatment (73 +/- 6%, n = 6). In addition, phagosomal acidification of the patients studied after treatment (63 +/- 4%) had no difference when compared with controls. This study demonstrates that phagosomal acidification is perturbed among chronic paracoccidioidomycosis patients and reverses with antifungal treatment.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paracoccidioidomicose / Fagossomos / Monócitos Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Mycoses Assunto da revista: MICROBIOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Paracoccidioidomicose / Fagossomos / Monócitos Limite: Adult / Humans / Male / Middle aged Idioma: En Revista: Mycoses Assunto da revista: MICROBIOLOGIA Ano de publicação: 2003 Tipo de documento: Article País de afiliação: Argentina País de publicação: Alemanha