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OBJECTIVES: To evaluate the feasibility of using the pulp volume (Pv) to total volume (Tv) ratio (Pv:Tv), obtained from cone beam computed tomography (CBCT) scans of single-rooted teeth, for age estimation in a Brazilian population sample. METHODS: After obtaining approval from the ethics committee, the study commenced by applying inclusion criteria to screen CBCT scans, resulting in a probability-based sample of participants aged 18 years and older (ranging from 18 to 82 years, with a mean age of 46.44 years). A total of 517 single-rooted teeth, including maxillary central incisors (CI), mandibular canines (C), and mandibular first premolars (FP), were chosen based on excellent agreement values (> 0.9). Pv and Tv measurements were conducted using semi-automatic segmentation with ITK-SNAP 3.8 software. Statistical analysis was performed using Jamovi software, with a significance level set at 5% (α = 0.05). RESULTS: A strong negative correlation (r > -0.7) was observed between chronological age and the Pv:Tv ratio across all examined teeth. However, when conducting regression analysis with Pv:Tv data and chronological age as the independent variable, only the mandibular FP teeth exhibited a normal distribution. The resulting linear model demonstrated moderate predictive value (approximately 64%) in explaining the variance in chronological age, but caution should be exercised when interpreting these findings. CONCLUSIONS: The method of measuring individual tooth volume using CBCT to estimate chronological age via Pv:Tv has been demonstrated as effective and reproducible within the Brazilian population sample.
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Determinação da Idade pelos Dentes , Tomografia Computadorizada de Feixe Cônico , Humanos , Pessoa de Meia-Idade , Adulto , Idoso , Feminino , Adolescente , Masculino , Idoso de 80 Anos ou mais , Determinação da Idade pelos Dentes/métodos , Brasil , Estudos de Viabilidade , Adulto Jovem , Polpa Dentária/diagnóstico por imagemRESUMO
PURPOSE: To evaluate the effectiveness of photobiomodulation in the treatment of oral mucositis. METHODS: Systematic review and meta-analysis encompassing in the electronic databases: LILACS, MEDLINE, EMBASE, COCHRANE, SCOPUS, WEB OF SCIENCE, and CINAHL and in http://clinicaltrials.gov . Eligibility criteria were randomized, non-randomized, and observational studies that used photobiomodulation for the treatment of oral mucositis. The endpoints were reduction in the severity of oral mucositis, duration of lesions, and pain reduction. For data analysis, the Review Manager 5.4 program was used. RESULTS: A total of 316 studies were identified, 297 in the electronic databases and 19 in http://clinicaltrials.gov . After removing duplicates, 260 studies were selected for title and abstract reading, of which 223 were excluded. A total of 37 studies were chosen for full reading, of which 6 were included in the review, totaling 299 patients. The treatment used was photobiomodulation. The patients were divided into two groups: the laser group used only photobiomodulation or associated with other therapies, and the control group did not use photobiomodulation. For the endpoint reduction in the severity of oral mucositis (OM), the chance of reduction of the OM was greater in the laser group as compared to the control group. For the endpoints duration of OM lesions and pain reduction, it was not possible to carry out a meta-analysis due to the high heterogeneity between studies. In the interpretation of the meta-analysis, the reduction in the severity of oral mucositis was greater in the group that received photobiomodulation. CONCLUSION: Photobiomodulation was effective in the treatment of oral mucositis.
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Antineoplásicos , Terapia com Luz de Baixa Intensidade , Úlceras Orais , Estomatite , Humanos , Terapia com Luz de Baixa Intensidade/efeitos adversos , Estomatite/tratamento farmacológico , Estomatite/etiologia , Estomatite/patologia , Antineoplásicos/efeitos adversos , Dor/etiologiaRESUMO
Nanotechnology-based strategies have played a pivotal role in innovative products in different technological fields, including medicine, agriculture, and engineering. The redesign of the nanometric scale has improved drug targeting and delivery, diagnosis, water treatment, and analytical methods. Although efficiency brings benefits, toxicity in organisms and the environment is a concern, particularly in light of global climate change and plastic disposal in the environment. Therefore, to measure such effects, alternative models enable the assessment of impacts on both functional properties and toxicity. Caenorhabditis elegans is a nematode model that poses valuable advantages such as transparency, sensibility in responding to exogenous compounds, fast response to perturbations besides the possibility to replicate human disease through transgenics. Herein, we discuss the applications of C. elegans to nanomaterial safety and efficacy evaluations from one health perspective. We also highlight the directions for developing appropriate techniques to safely adopt magnetic and organic nanoparticles, and carbon nanosystems. A description was given of the specifics of targeting and treatment, especially for health purposes. Finally, we discuss C. elegans potential for studying the impacts caused by nanopesticides and nanoplastics as emerging contaminants, pointing out gaps in environmental studies related to toxicity, analytical methods, and future directions.
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La necesidad de impulsar la investigación en Ortodoncia y realizar un análisis de los artículos publicados en la web cubana, con la finalidad de conocer sus características bibliométricas, es cada vez mayor. El presente estudio tuvo como objetivo caracterizar la producción científica sobre Ortodoncia, publicada en revistas biomédicas profesionales patrocinadas por las universidades médicas cubanas entre enero del 2015 y agosto del 2021. Se realizó un estudio bibliométrico, observacional, descriptivo, longitudinal de la productividad científica acerca de Ortodoncia publicada en dichas revistas. Se empleó el gestor de referencias Zotero para procesar los metadatos y VOSviewer para analizar las redes de coautoría. Se constataron 158 artículos; el 15,19 por ciento se publicó en Medisan y el año más productivo fue el 2015. Predominaron los artículos originales (67,72 por ciento), con autoría múltiple (cinco autores), el sexo femenino (76,41 por ciento), los autores de nacionalidad cubana (98,38 por ciento) y procedentes de Santiago de Cuba/Cuba (15,19 por ciento). Se emplearon 2665 referencias con un índice de Price de 0,53. El área temática más abordada fue la Ortodoncia interceptiva (33,54 por ciento). Los artículos recibieron un total de 1041 citas en el Google Académico. El análisis de la red de coautoría permitió establecer 13 clústeres, donde fueron visualizados 106 autores, con 282 links y una fuerza de atracción total entre ellos de 97. Se concluye que la producción científica sobre Ortodoncia, por lo general, es baja. Es necesario lograr la indexación de estas revistas en las grandes bases de datos para así aumentar la visibilidad e impacto de los artículos(AU)
The need to promote research in orthodontics and to carry out an analysis of the articles published in the Cuban web, with the purpose of knowing their bibliometric characteristics, is increasing. The present study aimed at characterizing the scientific production on orthodontics, published in professional biomedical journals sponsored by Cuban medical universities between January 2015 and August 2021. A bibliometric, observational, descriptive, longitudinal, descriptive study of the scientific productivity about Orthodontics published in these journals was carried out. The reference manager Zotero was used to process the metadata and VOSviewer to analyze the co-authorship networks. A total of 158 articles were ascertained; 15.19percent ere published in Medisan and the most productive year was 2015. Original articles predominated (67.72percent), with multiple authorship (five authors), female gender (76.41percent), authors of Cuban nationality (98.38percent) and from Santiago de Cuba/Cuba (15.19percent). A total of 2665 references were used with a Price index of 0.53. Interceptive orthodontics (33.54percent) was the most common subject area. The articles received a total of 1041 citations in Google Scholar. The analysis of the co-authorship network made it possible to establish 13 clusters, where 106 authors were visualized, with 282 links and a total strength of attraction among them of 97. It is necessary to achieve the indexing of these journals in large databases in order to increase the visibility and impact of the articles(AU)
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Humanos , Masculino , Feminino , Ortodontia , Publicações Seriadas , Bibliometria , Bibliometria , Indicadores de Produção Científica , Epidemiologia Descritiva , Estudos Longitudinais , Estudo ObservacionalRESUMO
Introducción: El personal de enfermería cumple un papel fundamental en tiempos de pandemia, porque aporta conocimientos, habilidades y experiencias de vida unido al equipo de salud. Objetivo: Comprender las experiencias adquiridas de las enseñanzas de los procesos sustantivos en el enfrentamiento a la COVID-19 en la práctica pediátrica, desde una perspectiva enfermera. Métodos: Estudio cualitativo fenomenológico transcendental, realizado en Hospital Pediátrico "Octavio de la Concepción", Holguín, Cuba, en el período febrero-abril de 2021. Se integraron experiencias de ocho enfermeras, siete médicos, cinco estudiantes de medicina y cinco de enfermería, seleccionados por muestreo no probabilístico. Se obtuvo la información a través de entrevistas semiestructuradas. Se recurrió a tres etapas, descriptiva (elección de técnica, entrevista, elaboración de la descripción), estructural (lectura, determinación del tema central, expresión en lenguaje científico) y discusión (comparación de hallazgos con los de otros investigadores) para entender diferencias y similitudes. Resultados: Del análisis de los datos emergieron tres categorías: a) Experiencias adquiridas en las enseñanzas durante la COVID-19 en los procesos sociales. b) Experiencias adquiridas en las enseñanzas durante la COVID-19 para los profesionales de la salud. c) Experiencias adquiridas en las enseñanzas durante la COVID-19 para el personal en formación. Conclusiones: Se evidenció la implementación de acciones sanitarias y de apoyo social en la accesibilidad a los sistemas de salud. La oportunidad de compartir experiencias con expertos que facilitaron el diseño de protocolos, generación continua de evidencia científica y la formación de estudiantes con métodos alternativos(AU)
Introduction: Nurses play a critical role in times of pandemic because they bring knowledge, skills, and life experiences together with the healthcare team. Objective: To understand the experiences gained from the lessons learned from the substantive processes in dealing with COVID-19 in pediatric practice, from a nursing perspective. Methods: Transcendental phenomenological qualitative study, carried out at the Pediatric Hospital "Octavio de la Concepción", Holguín, Cuba, in the period from February to April 2021. The experiences of eight nurses, seven physicians, five medical students and five nursing students, selected by non-probabilistic sampling, were integrated. Information was obtained through semi-structured interviews. Three stages were used: descriptive (choice of technique, interview, and formulation of the description), structural (reading, determination of the central theme, expression in scientific language) and discussion (comparison of findings with those of other researchers) to understand differences and similarities. Results: Three categories emerged from the data analysis: a) Experiences acquired in the teachings in the COVID-19 in social processes. b) Experiences acquired in the teachings in the COVID-19 for health professionals. c) Experiences acquired in the teachings in the COVID-19 for personnel in training. Conclusions: The implementation of health and social support actions in accessibility to health systems was evidenced. The opportunity to share experiences with experts facilitated the design of protocols, continuous generation of scientific evidence and the training of students with alternative methods(AU)
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Humanos , COVID-19/epidemiologiaRESUMO
OBJECTIVE: Characterise oral health, and the presence in the oral cavity of pathogenic non-oral microorganisms potentially associated with nosocomial infections and antimicrobial resistance in non-intubated patients admitted to a Brazilian university hospital. MATERIALS AND METHODS: An intraoral examination and oral swab were performed on hospitalized individuals at three different times, T1 (within 48 h of hospitalization), T2 (48 h after T1) and T3 (7 days after hospitalization). The oral health status was defined by the Oral Health Assessment Tool (OHAT) and Tongue Coating Status (TCS). The swabs were processed and microorganisms potentially related to nosocomial infections were phenotypically identified through colony morphology, staining and microscopy. RESULTS: The most prevalent microorganisms were Escherichia coli, Enterococcus spp., Enterobacter spp., Pseudomonas spp., Candida albicans and Staphylococcus aureus. The oral health status was considered median, and the tongue coating index was considered high throughout the study period. The prevalence of potentially pathogenic non-oral microorganisms was high and constant from the first 48 h to the seventh day of hospitalization. CONCLUSIONS: The results point out that the mouth can act as a reservoir of epidemiologically important pathogens within hospital settings, even in patients without mechanical ventilation, thus increasing the risk of nosocomial infections in susceptible individuals. KEY MESSAGESThe present study investigated the oral health status and the presence of pathogenic non-oral microorganisms in the oral cavity of patients hospitalized in the ward, non-intubated and mostly independent of self-care.The presence in the mouth of microorganisms related to the epidemiology of nosocomial infections and resistance to antimicrobials was high and constant from the first 48 h to the 7th day of hospitalization.The results of this study point out that the mouth can act as a reservoir of epidemiologically important pathogens within hospital settings even in patients without mechanical ventilation, increasing the risk of nosocomial infections in susceptible individuals.
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Doenças Transmissíveis , Infecção Hospitalar , Infecções Estafilocócicas , Infecção Hospitalar/epidemiologia , Humanos , Saúde Bucal , Staphylococcus aureusRESUMO
Introducción: Resulta indispensable la organización de los servicios pediátricos en el actual proceso de enfrentamiento a la pandemia COVID-19. Objetivo: Describir, desde una perspectiva enfermera, la representación social sobre gestión en la organización de los servicios hospitalarios pediátricos para la atención de pacientes sospechosos de COVID-19. Métodos: Estudio cualitativo de orientación metodológica fenomenológica transcendental, realizado en Hospital Pediátrico "Octavio de la Concepción de la Pedraja", Holguín, Cuba, entre enero y abril del 2021. Se integraron los conocimientos adquiridos de la experiencia de enfermeras, cinco supervisoras, tres jefas de áreas y ocho jefas de salas, seleccionadas por muestreo no probabilístico. Se recurrió a las etapas: descriptiva, estructural y discusión. La descriptiva constó de tres etapas: elección de técnica, entrevista semiestructurada y elaboración de la descripción. La etapa estructural: lectura, determinación del tema central, expresión en lenguaje científico y etapa de discusión de los resultados, se relacionaron con las conclusiones y hallazgos de investigadores para entender las posibles diferencias o similitudes para mayor enriquecimiento. Resultados: Del análisis de los datos emergieron cuatro categorías: Categoría I: diseño de los protocolos de atención de enfermería para pacientes sospechosos y positivos a COVID-19. Categoría II: reorganización, reclutamiento y capacitación de personal. Categoría III: organizar grupos de trabajo según cuadro clínico y resultado del test rápido y el PCR. Categoría IV: medidas generales. Conclusiones: La organización de los servicios de atención de enfermería por grupos evitó el colapso del recurso humano enfermero y garantizó la disponibilidad de camas, la seguridad propia y del paciente para minimizar la transmisibilidad intrahospitalaria(AU)
Introduction: The organization of pediatric services is essential in the current process of confronting the COVID-19 pandemic. Objective: To describe, from a nursing perspective, the social representation on management in the organization of pediatric hospital services for the care of patients suspected of COVID-19. Methods: A qualitative study of transcendental phenomenological methodological orientation was carried out at Octavio de la Concepción de la Pedraja Pediatric Hospital from Holguín, Cuba, between January and April 2021. The knowledge acquired from the experience of nurses, five supervisors, three area heads and eight ward chiefs, selected by nonprobabilistic sampling, was integrated. The following phases were used: descriptive, structural and discussion. The descriptive phase consisted of three stages: choice of technique, semistructured interview and elaboration of the description. The structural phase had the following stages: reading, determination of the central topic and expression in scientific language. In the results discussion phase, the results were related to the conclusions and findings of researchers to understand the possible differences or similarities for further enhancement. Results: Four categories emerged from the data analysis: design of nursing care protocols for COVID-19 positive and suspect patients; reorganization, recruitment and training of personnel; organization of working groups according to clinical picture and rapid test or PCR results; and general measures. Conclusions: The organization of nursing care services by groups avoided the collapse of the nursing human resource and guaranteed the availability of beds, as well as staff own safety and patient safety, to minimize in-hospital transmissibility(AU)
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Humanos , COVID-19/epidemiologia , Cuidados de Enfermagem/métodos , Serviços de SaúdeRESUMO
Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease defined as a defect in the lymphocyte apoptotic pathway. Currently, the diagnosis of ALPS is based on clinical aspects, defective lymphocyte apoptosis and mutations in Fas, FasL and Casp 10 genes. Despite this, ALPS has been misdiagnosed. The aim of this work was to go one step further in the knowledge of the disease, through a molecular and proteomic analysis of peripheral blood mononuclear cells (PBMCs) from two children, a 13-year-old girl and a 6-year-old boy, called patient 1 and patient 2, respectively, with clinical data supporting the diagnosis of ALPS. Fas, FasL and Casp10 genes from both patients were sequenced, and a sample of the total proteins from patient 1 was analyzed by label-free proteomics. Pathway analysis of deregulated proteins from PBMCs was performed on the STRING and PANTHER bioinformatics databases. A mutation resulting in an in-frame premature stop codon and protein truncation was detected in the Fas gene from patient 2. From patient 1, the proteomic analysis showed differences in the level of expression of proteins involved in, among other processes, cell cycle, regulation of cell cycle arrest and immune response. Noticeably, the most down-regulated protein is an important regulator of the cell cycle process. This could be an explanation of the disease in patient 1.
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Síndrome Linfoproliferativa Autoimune , Adolescente , Síndrome Linfoproliferativa Autoimune/diagnóstico , Síndrome Linfoproliferativa Autoimune/genética , Criança , Feminino , Humanos , Leucócitos Mononucleares , Masculino , Mutação , Proteômica , Receptor fas/genéticaRESUMO
PURPOSE: Although trauma represents a leading cause of morbidity and mortality worldwide, there is limited and heterogeneous evidence regarding trauma recidivism and its outcomes. This analysis determined the rate and independent risk factors of trauma recidivism and compared the first and second injury episode among recidivists. METHODS: An IRB-approved retrospective cohort study was performed with data from the Puerto Rico Trauma Hospital Registry. Bivariate analyses were done using Pearson's Chi squared, Wilcoxon rank-sum, McNemar, Stuart-Maxwell or Wilcoxon signed-rank tests, as appropriate. Independent predictors for recidivism were determined through a logistic regression model. Statistical significance was set at p < 0.05. RESULTS: 24,650 patients were admitted to the hospital during 2000-2017. Recidivism rate was 14 per 1,000 patients discharged alive. Males and individuals aged 15-24 years old were 3.88 (95% CI: 2.21-6.80) and 3.80 (95% CI: 2.24-6.46) times more likely to be recidivists, respectively. Contrariwise, an ISS [Formula: see text] 25 [adjusted odds ratio (AOR) = 0.44; 95% CI: 0.28-0.68] and a GCS [Formula: see text] 8 (AOR = 0.56; 95% CI 0.34-0.92) were protective factors. Furthermore, recidivists exhibited less in-hospital mortality than their non-recidivist counterparts (7.2% vs. 10.7%; p = 0.045). For recidivists, the median (interquartile range) time to reinjury was 42 (59) months; and the second injury episode was more severe than the first one, as the proportion of patients with ISS [Formula: see text] 25 increased (7.9% vs. 14.1%; p = 0.022). CONCLUSION: The independent predictors of trauma recidivism and the median time to reinjury identified in this study provide valuable information to the development of prevention strategies aimed at reducing the burden of injury.
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Relesões , Ferimentos e Lesões , Adolescente , Adulto , Hospitais , Humanos , Masculino , Readmissão do Paciente , Porto Rico/epidemiologia , Estudos Retrospectivos , Centros de Traumatologia , Adulto JovemRESUMO
Abstract Background: Pulmonary involvement in juvenile systemic sclerosis (JSSc) is rare in children and contributes to morbimortality. This study aimed to describe the pulmonary function and clinical, radiologic, and tomographic findings in JSSc. Methods: Patients with JSSc between 5-14 years of age were included. Clinical, functional, and imaging characteristics were assessed. Patients were excluded if they showed lung disease not associated with JSSc: mixed connective tissue disease, overlap syndrome, or acute cardiopulmonary failure at the time of the study. All patients underwent physical examination, electrocardiogram, spirometry, chest X-ray, high-resolution computed tomography (HRCT) of the chest, echocardiography, lung function tests, and the 6-minute walk test (6-MWT). Descriptive statistics were employed for data analysis. Results: We studied 15 patients with the following characteristics: median age, 11 years; median since symptoms onset, 6 years; median since JSSc diagnosis and the finding of pulmonary involvement, 2 years. Lung disease was detected in 73%, interstitial lung disease (ILD) the most common affection (67%); pulmonary hypertension was found in 6.6%. 6-MWT was positive in 26.6%, forced vital capacity (FVC) was abnormal in 26.6%. No pulmonary involvement was found in four patients. Conclusions: The most frequent pulmonary affection in JSSc was ILD. Thus, early JSSc detection and periodic lung monitoring are mandatory to avoid further complications once JSSc is diagnosed.
Resumen Introducción: La afección pulmonar en la esclerosis sistémica juvenil (ESJ) es rara en niños y contribuye a la morbimortalidad. El objetivo de este estudio fue describir los hallazgos de función pulmonar, clínicos, radiológicos y tomográficos en la ESJ. Métodos: Se incluyeron pacientes con ESJ de 5-14 años de edad. Se evaluaron las características clínicas, funcionales y de imagen. No se incluyeron pacientes con enfermedades pulmonares no asociadas con ESJ en el momento del estudio: enfermedad mixta del tejido conectivo, síndrome de superposición o insuficiencia cardiopulmonar aguda. Se realizaron exploración física, electrocardiograma, espirometría, radiografía de tórax, tomografía computarizada de alta resolución de tórax, ecocardiografía, pruebas de función pulmonar y prueba de caminata de 6 minutos (PC6M). Se utilizó estadística descriptiva para el análisis de los datos. Resultados: Se estudiaron 15 pacientes con las siguientes características: mediana de edad, 11 años; mediana desde el inicio de los síntomas, 6 años; y mediana desde el diagnóstico de ESJ y hallazgo de afección pulmonar, 2 años. Se detectó enfermedad pulmonar en el 73%. La enfermedad pulmonar intersticial (EPI) fue la afección más común (67%) y se encontró hipertensión pulmonar en el 6.6%. La PC6M fue positiva en el 26.6%, y la capacidad vital forzada resultó anormal en el 26.6%. Cuatro pacientes no presentaron afección pulmonar. Conclusiones: La afección pulmonar más frecuente en la ESJ fue la EPI. La detección temprana de ESJ y la monitorización pulmonar periódica son obligatorias para evitar más complicaciones una vez diagnosticada la ESJ.
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Background: Pulmonary involvement in juvenile systemic sclerosis (JSSc) is rare in children and contributes to morbimortality. This study aimed to describe the pulmonary function and clinical, radiologic, and tomographic findings in JSSc. Methods: Patients with JSSc between 5-14 years of age were included. Clinical, functional, and imaging characteristics were assessed. Patients were excluded if they showed lung disease not associated with JSSc: mixed connective tissue disease, overlap syndrome, or acute cardiopulmonary failure at the time of the study. All patients underwent physical examination, electrocardiogram, spirometry, chest X-ray, high-resolution computed tomography (HRCT) of the chest, echocardiography, lung function tests, and the 6-minute walk test (6-MWT). Descriptive statistics were employed for data analysis. Results: We studied 15 patients with the following characteristics: median age, 11 years; median since symptoms onset, 6 years; median since JSSc diagnosis and the finding of pulmonary involvement, 2 years. Lung disease was detected in 73%, interstitial lung disease (ILD) the most common affection (67%); pulmonary hypertension was found in 6.6%. 6-MWT was positive in 26.6%, forced vital capacity (FVC) was abnormal in 26.6%. No pulmonary involvement was found in four patients. Conclusions: The most frequent pulmonary affection in JSSc was ILD. Thus, early JSSc detection and periodic lung monitoring are mandatory to avoid further complications once JSSc is diagnosed.
Introducción: La afección pulmonar en la esclerosis sistémica juvenil (ESJ) es rara en niños y contribuye a la morbimortalidad. El objetivo de este estudio fue describir los hallazgos de función pulmonar, clínicos, radiológicos y tomográficos en la ESJ. Métodos: Se incluyeron pacientes con ESJ de 5-14 años de edad. Se evaluaron las características clínicas, funcionales y de imagen. No se incluyeron pacientes con enfermedades pulmonares no asociadas con ESJ en el momento del estudio: enfermedad mixta del tejido conectivo, síndrome de superposición o insuficiencia cardiopulmonar aguda. Se realizaron exploración física, electrocardiograma, espirometría, radiografía de tórax, tomografía computarizada de alta resolución de tórax, ecocardiografía, pruebas de función pulmonar y prueba de caminata de 6 minutos (PC6M). Se utilizó estadística descriptiva para el análisis de los datos. Resultados: Se estudiaron 15 pacientes con las siguientes características: mediana de edad, 11 años; mediana desde el inicio de los síntomas, 6 años; y mediana desde el diagnóstico de ESJ y hallazgo de afección pulmonar, 2 años. Se detectó enfermedad pulmonar en el 73%. La enfermedad pulmonar intersticial (EPI) fue la afección más común (67%) y se encontró hipertensión pulmonar en el 6.6%. La PC6M fue positiva en el 26.6%, y la capacidad vital forzada resultó anormal en el 26.6%. Cuatro pacientes no presentaron afección pulmonar. Conclusiones: La afección pulmonar más frecuente en la ESJ fue la EPI. La detección temprana de ESJ y la monitorización pulmonar periódica son obligatorias para evitar más complicaciones una vez diagnosticada la ESJ.
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Doenças Pulmonares Intersticiais , Esclerodermia Localizada , Escleroderma Sistêmico , Criança , Humanos , Pulmão/diagnóstico por imagem , Testes de Função Respiratória , Escleroderma Sistêmico/complicações , Escleroderma Sistêmico/diagnósticoRESUMO
Deregulation of miRNAs contributes to the development of distinct cancer types, including melanoma, an aggressive form of skin cancer characterized by high metastatic potential and poor prognosis. The expression of a set of 580 miRNAs was investigated in a model of murine melanoma progression, comprising non-metastatic (4C11-) and metastatic melanoma (4C11+) cells. A significant increase in miR-138-5p expression was found in the metastatic 4C11+ melanoma cells compared to 4C11-, which prompted us to investigate its role in melanoma aggressiveness. Functional assays, including anoikis resistance, colony formation, collective migration, serum-deprived growth capacity, as well as in vivo tumor growth and experimental metastasis were performed in 4C11- cells stably overexpressing miR-138-5p. miR-138-5p induced an aggressive phenotype in mouse melanoma cell lines leading to increased proliferation, migration and cell viability under stress conditions. Moreover, by overexpressing miR-138-5p, low-growing and non-metastatic 4C11- cells became highly proliferative and metastatic in vivo, similar to the metastatic 4C11+ cells. Luciferase reporter analysis identified the tumor suppressor Trp53 as a direct target of miR-138-5p. Using data sets from independent melanoma cohorts, miR-138-5p and P53 expression were also found deregulated in human melanoma samples, with their levels negatively and positively correlated with prognosis, respectively. Our data shows that the overexpression of miR-138-5p contributes to melanoma metastasis through the direct suppression of Trp53.
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Regulação Neoplásica da Expressão Gênica , Melanoma/genética , Melanoma/mortalidade , MicroRNAs/genética , Interferência de RNA , Proteína Supressora de Tumor p53/genética , Regiões 3' não Traduzidas , Animais , Linhagem Celular Tumoral , Humanos , Melanoma/patologia , Camundongos , Metástase Neoplásica , Estadiamento de Neoplasias , Prognóstico , Análise de SobrevidaRESUMO
OBJECTIVE: To describe clinical, radiological and treatment characteristics in pediatric patients with SLS. MATERIAL AND METHODS: This is a descriptive and retrospective study in patients under 16 years old with the diagnosis of SLE complicated by SLS at the General Hospital. National Medical Center La Raza. Clinical, radiological and treatment variables were analyzed. Results are shown in frequencies and percentages. RESULTS: Data from 11 patients, 9 females and 2 males were collected. Mean age at diagnosis of SLS was 12.2 years. Age at diagnosis of SLE was 11.1 years. SLEDAI 17.3. Renal desease 72%, hematological 91%, lymphopenia 63%, mucocutaneous 72%, neurological 9%, arthritis 54%, serositis 91%, fever 81%, secondary antiphospholipid syndrome, low C3 72%, low C4 81%, positive ANA 91%, positive anti-DNA 91%. Regarding clinical manifestations of SLE: cough 81%, dyspnea 91%, hipoxemia 81%, pleuritic pain 71%, average oxygen saturation 83%. Chest X-rays findings: right hemidiaphragm affection 18%, left 63%, bilateral 18%. Elevated hemidiaphragm 91%, atelectasis 18%, pleural effusion 91%, over one third of the cardiac silhouette under the diphragm 36%, bulging diaphragm 45%, 5th. anterior rib that crosses over the diaphragm 91%. M-mode ultrasound: diaphragmatic hypomotility 100%, pleural effusion 63%. Pulmonary function tests: restrictive pattern in 45% of the cases. Treatment was with supplementary oxygen 100%, intubation 18%, antibiotics 100%, steroids 100%, intravenous immunoglobulin 54%, plasmapheresis 18%, cyclophosphamide 54% and rituximab 18%. The clinical course was favorable in 81%. CONCLUSIONS: SLS should be suspected in patients with SLE and active disease who present hipoxemia, pleuritic pain, cough, dyspnea, pleural effusion and signs of restriction on chest X-rays. Therefore, a diaphragmatic M-mode ultrasound should be performed in order to establish the diagnosis.
Assuntos
Diafragma/anormalidades , Diafragma/fisiopatologia , Pneumopatias/etiologia , Pneumopatias/fisiopatologia , Lúpus Eritematoso Sistêmico/complicações , Adolescente , Antibacterianos/uso terapêutico , Síndrome Antifosfolipídica/complicações , Síndrome Antifosfolipídica/diagnóstico , Síndrome Antifosfolipídica/imunologia , Dor no Peito/etiologia , Criança , Terapia Combinada/métodos , Ciclofosfamida/uso terapêutico , Diafragma/diagnóstico por imagem , Dispneia/etiologia , Feminino , Humanos , Hipóxia/etiologia , Imunoglobulinas Intravenosas/uso terapêutico , Fatores Imunológicos/uso terapêutico , Imunossupressores/uso terapêutico , Intubação Intratraqueal/métodos , Pneumopatias/terapia , Lúpus Eritematoso Sistêmico/diagnóstico , Lúpus Eritematoso Sistêmico/imunologia , Masculino , México/epidemiologia , Oxigênio/administração & dosagem , Oxigênio/uso terapêutico , Plasmaferese/métodos , Pleurisia/complicações , Atelectasia Pulmonar/etiologia , Estudos Retrospectivos , Rituximab/uso terapêutico , Esteroides/uso terapêutico , Ultrassonografia/métodosRESUMO
OBJECTIVE: To describe the prevalence of knowledge about neurodevelopment disorders (NDDs) and the level of acceptance of models of inclusive education (IEM) in teachers. MATERIALS AND METHODS: A multicenter cross-sectional study in Mexico and Central America. A self-report instrument to teachers of basic level on knowledge in NDDs and acceptance of the IEM. RESULTS: The response of 511 teachers was obtained. The prevalence of high acceptance of the IEM was 28.6%. Of the 120 teachers who reported having extensive knowledge about intellectual disability, 3.8% were in the lowest percentile of acceptance of the IEM, 19.5% in the average percentile of acceptance and 55.5% of them were in the highest percentile acceptance (p<0.001). Among teachers, a greater knowledge about NDDs was associated with the acceptance of IEM: learning disorders RM 3.76 (95%CI 2.13-6.62); attention deficit disorders with hyperactivity RM 2.24 (95%CI 1.31-3.84) and intellectual disability RM 3.84 (95%CI 2.46-5.99). CONCLUSIONS: The teaching acceptance of IEM can be favored with greater and better training of education professionals on the different NDDs.
OBJETIVO: Describir la prevalencia del conocimiento sobre trastornos del neurodesarrollo (TdN) y el nivel de aceptación de los modelos de educación inclusiva (MEI) en docentes. MATERIAL Y MÉTODOS: Estudio transversal multicéntrico en México y Centroamérica. Aplicación de un instrumento de autorreporte a docentes de nivel básico sobre conocimiento en TdN y aceptación de los MEI. RESULTADOS: Se obtuvo la respuesta de 511 docentes. La prevalencia de alta aceptación de MEI fue de 28.6%. De los 120 docentes que refirieron tener un amplio conocimiento sobre discapacidad intelectual, 3.8% estuvieron en el percentil más bajo de aceptación de MEI, 19.5% en el percentil de aceptación promedio y 55.5% de ellos se encontraron en el percentil de mayor aceptación (p<0.001). Entre los docentes, un mayor conocimiento sobre los TdN se mostró asociado con la aceptación de MEI: trastornos del aprendizaje RM 3.76 (IC95% 2.13-6.62); trastornos por déficit de atención con hiperactividad RM 2.24 (IC95% 1.31-3.84) y discapacidad intelectual RM 3.84 (IC95% 2.46-5.99). CONCLUSIONES: La aceptación docente de MEI puede favorecerse con una mayor y mejor capacitación de los profesionales de la educación sobre los diferentes TdN.
Assuntos
Transtorno do Deficit de Atenção com Hiperatividade , Deficiência Intelectual , Transtornos do Neurodesenvolvimento , Capacitação de Professores , Estudos Transversais , Humanos , Conhecimento , Transtornos do Neurodesenvolvimento/epidemiologiaRESUMO
Resumen Objetivo: Describir la prevalencia del conocimiento sobre trastornos del neurodesarrollo (TdN) y el nivel de aceptación de los modelos de educación inclusiva (MEI) en docentes. Material y métodos: Estudio transversal multicéntrico en México y Centroamérica. Aplicación de un instrumento de autorreporte a docentes de nivel básico sobre conocimiento en TdN y aceptación de los MEI. Resultados: Se obtuvo la respuesta de 511 docentes. La prevalencia de alta aceptación de MEI fue de 28.6%. De los 120 docentes que refirieron tener un amplio conocimiento sobre discapacidad intelectual, 3.8% estuvieron en el percentil más bajo de aceptación de MEI, 19.5% en el percentil de aceptación promedio y 55.5% de ellos se encontraron en el percentil de mayor aceptación (p<0.001). Entre los docentes, un mayor conocimiento sobre los TdN se mostró asociado con la aceptación de MEI: trastornos del aprendizaje RM 3.76 (IC95% 2.13-6.62); trastornos por déficit de atención con hiperactividad RM 2.24 (IC95% 1.31-3.84) y discapacidad intelectual RM 3.84 (IC95% 2.46-5.99). Conclusión: La aceptación docente de MEI puede favorecerse con una mayor y mejor capacitación de los profesionales de la educación sobre los diferentes TdN.
Abstract Objective: To describe the prevalence of knowledge about neurodevelopment disorders (NDDs) and the level of acceptance of models of inclusive education (IEM) in teachers. Materials and methods: A multicenter crosssectional study in Mexico and Central America. A self-report instrument to teachers of basic level on knowledge in NDDs and acceptance of the IEM. Results: The response of 511 teachers was obtained. The prevalence of high acceptance of the IEM was 28.6%. Of the 120 teachers who reported having extensive knowledge about intellectual disability, 3.8% were in the lowest percentile of acceptance of the IEM, 19.5% in the average percentile of acceptance and 55.5% of them were in the highest percentile acceptance (p<0.001). Among teachers, a greater knowledge about NDDs was associated with the acceptance of IEM: learning disorders RM 3.76 (95%CI 2.13-6.62); attention deficit disorders with hyperactivity RM 2.24 (95%CI 1.31-3.84) and intellectual disability RM 3.84 (95%CI 2.46-5.99). Conclusion: The teaching acceptance of IEM can be favored with greater and better training of education professionals on the different NDDs.
Assuntos
Humanos , Transtorno do Deficit de Atenção com Hiperatividade , Transtornos do Neurodesenvolvimento , Capacitação de Professores , Deficiência Intelectual , Estudos Transversais , Conhecimento , Transtornos do Neurodesenvolvimento/epidemiologiaRESUMO
Macrophages are essential cells of the innate immune response against microbial infections, and they have the ability to adapt under both pro- and anti-inflammatory conditions and develop different functions. A growing body of evidence regarding a novel macrophage subpopulation that expresses CD3 has recently emerged. Here, we explain that human circulating monocytes can be differentiated into CD3+TCRαß+ and CD3+TCRαß- macrophages. Both cell subpopulations express on their cell surface HLA family molecules, but only the CD3+TCRαß+ macrophage subpopulation co-express CD1 family molecules and transmembrane TNF (tmTNF). CD3+TCRαß+ macrophages secrete IL-1ß, IL-6 IP-10, and MCP-1 by both tmTNF- and CD3-dependent pathways, while CD3+TCRαß- macrophages specifically produce IFN-γ, TNF, and MIP-1ß by a CD3-dependent pathway. In this study, we also used a mouse model of BCG-induced pleurisy and demonstrated that CD3+ myeloid cells (TCRαß+ and TCRαß- cells) are increased at the infection sites during the acute phase (2 weeks post-infection). Interestingly, cell increment was mediated by tmTNF, and the soluble form of TNF was dispensable. BCG-infection also induced the expression of TNF receptor 2 on CD3+ myeloid cells, which increased after BCG-infection, suggesting that the tmTNF/TNFRs axis plays an important role in the presence or function of these cells in tuberculosis.
Assuntos
Complexo CD3/imunologia , Citocinas/metabolismo , Macrófagos/imunologia , Animais , Apresentação de Antígeno , Vacina BCG/administração & dosagem , Diferenciação Celular , Células Cultivadas , Modelos Animais de Doenças , Humanos , Inflamação/imunologia , Leucócitos Mononucleares/imunologia , Macrófagos/citologia , Camundongos , Camundongos Endogâmicos C57BL , Pleurisia/induzido quimicamente , Pleurisia/imunologia , Fator de Necrose Tumoral alfa/imunologiaRESUMO
Synthesis of a new HKUST-1 composite based on single-walled carbon nanotubes (SWCNTs) was successfully achieved (SWCNT@HKUST-1). SWCNTs were used as templates to grow rod-like HKUST-1 crystals over the surface of the nanotubes. N2 adsorption properties showed an increment on the surface area and pore volume for the SWCNT@HKUST-1 composite. Furthermore, the CO2 capture increased, from 7.92 to 8.75 mmol g-1 at 196 K up to 100 kPa, for the SWCNT@HKUST-1 composite. This enhancement was directly associated with the increase of the surface area of the composite. Additionally, an increase in the CO2 heat of adsorption was estimated, from 30 to 39.1 kJ mol-1 for the SWCNT@HKUST-1 composite. In situ Raman experiments corroborated the favored CO2 adsorption for the composite and provided an insight into the augmented hydrophobicity of the SWCNT@HKUST-1. Ethanol adsorption isotherms corroborated an increase in the hydrophobicity of the material upon the incorporation of carbon nanotubes.
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La sífilis es una infección crónica de transmisión sexual, causada por la espiroqueta Treponema pallidum. A pesar de existir un tratamiento eficaz, continúa siendo un importante problema de salud pública. La Organización Mundial de la Salud (OMS) ha estimado que más de 6 millones de personas se infectan cada año en el mun-do (1), y los Centros para el Con-trol y la Prevención de Enferme-dades (CDC) de Estados Unidos reportaron con preocupación, en el 2017, una incidencia de sífilis primaria y secundaria de 9,5 casos por cada 100 000 habitantes, lo que equivale a un incremento del 72,7 % en comparación con el 2013 (2). En Colombia, se estima una preva-lencia de sífilis venérea sustan-cialmente mayor, del 1,25 % (3)
Syphilis is a chronic sexually transmitted infection, caused by the spirochete Treponema pallidum. Despite effective treatment, it remains a major public health problem. The World Health Organization (WHO) has estimated that more than 6 million people infected each year in the world (1), and the Centers for Disease Control and Prevention (CDC) in the United States reported with concern, in 2017, an incidence of primary and secondary syphilis of 9.5 cases per 100,000 inhabitants, equivalent to an increase of 72.7% compared to 2013 (2). In Colombia, a prevalence of substantially greater venereal syphilis is estimated at 1.25% (3
Assuntos
Humanos , Sífilis , Spirochaetales , Infecções Sexualmente Transmissíveis , DiagnósticoRESUMO
Introducción: Las enterobacterias han ido adquiriendo mecanismos de resistencia a los antimicrobianos, como la producción de Beta Lactamasas de Espectro Extendido (BLEE) que otorga resistencia a varios beta-lactámicos. Estas bacterias, capaces de causar infecciones intrahospitalarias y comunitarias difíciles de tratar, se están diseminando y habitan reservorios ambientales, como aguas;y es considerado un problema de salud pública. Situación desconocida en nuestro medio. Objetivo: Identificar Enterobacterias productoras de BLEE y AmpC en agua de los ríos Tamborada y Rocha, utilizados para el riego de cultivos en la zona Maica de Cochabamba. Métodos: Estudio descriptivo, transversal y cuantitativo. Se analizaron 70 muestras de agua: 44 del rio Tamborada y 26 del Rocha. Las muestras se cultivaron en Agar MacConkey con Cefotaxima (2 μm/ml). Las bacterias que crecieron se identificaron con agar cromogénico y pruebas bioquímicas. Las cepas productoras de BLEE y tipo AmpC se determinaron por difusión y aproximación de discos: Cefotaxima, ceftazidima, Amoxicilina/Acido clavulánico para BLEE y Cefoxitin para AmpC. Resultados: Se aislaron 23 cepas de Escherichia coli (E. coli) productoras de BLEE (32,8%) de las 70 muestras y 22 muestras (resistentes a cefoxitin) que podrían tener además resistencia tipo AmpC. Conclusión: E. coli productoras de BLEE y probablemente AmpC están circulando en ambientes de nuestro medio como ser agua de Ríos Tamborada y Rocha, esto representa un problema de salud pública, más si consideramos que estas aguas son utilizadas en riego de verduras que abastecen los mercados de Cochabamba y pueden diseminar estas bacterias entre la población.
Introduction: Enterobacteria have been acquiring antimicrobial resistance mechanisms, such as the production of extended spectrum beta lactamases (ESBL) thatgives resistance to several beta-lactams.These bacteria, capable of causing intrahospital and community infections difficult to treat, are spreading and inhabit environmental reservoirs, such as water; and is considered a public health problem. Unknown situation in our environment. Objective: Identify Enterobacteria producing BLEE and AmpC in water from the Tamborada and Rocha rivers, used for irrigation of crops in the Maica area of Cochabamba. Methods: Descriptive, cross-sectional and quantitative study. 70 water samples were analyzed: 44 from the Tamborada river and 26 from Rocha.The samples were grown in MacConkey Agar with Cefotaxime (2 μm/ml). Bacteria that grew were identified with chromogenic agar and biochemical tests.The ESBL and AmpC type producing strains were determined by diffusion and approximation of discs: Cefotaxime, Ceftazidime, Amoxicillin/Clavulanic acid for ESBL; and Cefoxitin for AmpC. Results: 23 strains of ESBL-producing Escherichia coli (32.8%) were isolated from the 70 samples. 22 of these isolates (resistant to cefoxitin) could also have AmpC resistance. Conclusion: E. coli producers of ESBL and probably AmpC are circulating in our environment such as waters of Rocha and Tamborada rivers, which represent a public health problem, more if we consider that these waters are used in irrigation of vegetables that they supply Cochabamba markets and can spread these bacteria among the population.
RESUMO
[ABSTRACT]. Objectives. To estimate adult (15–49 years old) prevalence and incidence of active syphilis, gonorrhea, and chlamydia, and incidence of congenital syphilis (CS) and adverse birth outcomes (ABOs) in Colombia, over 1995–2016. Methods. The Spectrum-STI epidemiological model tool estimated gonorrhea and chlamydia prevalences as moving averages across prevalences observed in representative general population surveys. For adult syphilis, Spectrum-STI applied segmented polynomial regression through prevalence data from antenatal care (ANC) surveys, routine ANC-based screening, and general population surveys. CS cases and ABOs were estimated from Spectrum’s maternal syphilis estimates and proportions of women screened and treated for syphilis, applying World Health Organization case definitions and risk probabilities. Results. The Spectrum model estimated prevalences in 2016 of 0.70% (95% confidence interval (CI): 0.15%-1.9%) in women and 0.60% (0.1%-1.9%) in men for gonorrhea and of 9.2% (4.4%-15.4%) in women and 7.4% (3.5%-14.7%) in men for chlamydia, without evidence for trends over 1995–2016. The prevalence of active syphilis in 2016 was 1.25% (1.22–1.29%) in women and 1.25% (1.1%-1.4%) in men, decreasing from 2.6% (2.1%-3.2%) in women in 1995. Corresponding CS cases in 2016 (including cases without clinical symptoms) totaled 3 851, of which 2 245 were ABOs. Annual CS and ABO estimates decreased over 2008–2016, reflecting decreasing maternal prevalence and increasing cases averted through ANC-based screening and treatment. Conclusions. The available surveillance and monitoring data synthesized in Spectrum-STI—and the resulting first-ever national STI estimates for Colombia—highlighted Colombia’s persistently high STI burden. Adult syphilis and congenital syphilis are estimated to be falling, reflecting improving screening efforts. Strengthened surveillance, including with periodic screening in low-risk populations and future refined Spectrum estimations, should support planning and implementation of STI prevention and control, including CS elimination.
[RESUMEN]. Objetivos. Estimar la prevalencia e incidencia en los adultos (de 15 a 49 años de edad) de sífilis activa, gonorrea y clamidiasis, así como la incidencia de sífilis congénita y resultados adversos del embarazo en Colombia durante el período de 1995 al 2016. Métodos. Usando las herramientas del modelo epidemiológico Spectrum-STI se estimó la prevalencia de gonorrea y clamidiasis como promedios móviles entre las distintas prevalencias observadas en encuestas representativas de la población general. En cuanto a la sífilis en los adultos, Spectrum-STI aplicó la regresión polinomial segmentada a los datos sobre prevalencia recopilados en encuestas de atención prenatal, el tamizaje sistemático en la atención prenatal y encuestas a la población general. Los casos de sífilis congénita y de resultados adversos del embarazo se estimaron a partir de las cifras de Spectrum sobre sífilis materna y proporciones de mujeres examinadas y tratadas por sífilis, aplicando las definiciones de casos y probabilidades de riesgo de la Organización Mundial de la Salud. Resultados. El modelo Spectrum estimó que en el 2016 la prevalencia de la gonorrea fue de 0,70% (intervalo de confianza de 95% [IC]: 0,15%-1,9%) en las mujeres y de 0,60% (0,1%-1,9%) en los hombres, y que la prevalencia de la clamidiasis fue de 9,2% (4,4%-15,4%) en las mujeres y de 7,4% (3,5%-14,7%) en los hombres, sin datos científicos acerca de las tendencias durante el período 1995-2016. La prevalencia de la sífilis activa en el 2016 fue de 1,25% (1,22-1,29%) en las mujeres y de 1,25% (1,1%-1,4%) en los hombres, con una reducción de 2,6% (2,1%-3,2%) en las mujeres con respecto a 1995. Los casos correspondientes de sífilis congénita en el 2016 (incluidos los asintomáticos) sumaron en total 3 851, de los cuales 2 245 fueron resultados adversos del embarazo. Las cifras anuales estimadas de sífilis congénita y resultados adversos del embarazo disminuyeron entre el 2008 y el 2016, lo que reflejó un descenso en la prevalencia materna y un aumento de casos evitados mediante el tamizaje y el tratamiento durante la atención prenatal. Conclusiones. Los datos disponibles sobre vigilancia y seguimiento sintetizados en Spectrum‑STI, así como los consiguientes estimados nacionales de infecciones de transmisión sexual (ITS) hechos por primera vez en Colombia, pusieron de relieve la carga de morbilidad por ITS persistentemente alta en ese país. Se estima que la sífilis en los adultos y la sífilis congénita van en descenso, lo que refleja mejoras en las actividades de tamizaje. Un fortalecimiento de la vigilancia, incluso con tamizaje periódico en las poblaciones de bajo riesgo, y estimaciones más refinadas con Spectrum en el futuro deberían brindar apoyo a la planificación y la ejecución de medidas para la prevención y el control de las infecciones de transmisión sexual, incluida la eliminación de la sífilis congénita.
[RESUMO]. Objetivos. Estimar a incidência e a prevalência na população adulta (com idade de 15–49 anos) de sífilis ativa, gonorreia e clamídia e a incidência de sífilis congênita (SC) e desfechos adversos congênitos na Colômbia no período de 1995 a 2016. Métodos. O modelo epidemiológico Spectrum-STI foi o instrumento usado para estimar a prevalência de gonorreia e clamídia como médias móveis nas prevalências observadas em pesquisas representativas da população geral. A sífilis em adultos foi estimada com a regressão polinomial segmentada aplicada ao modelo Spectrum-STI com dados de prevalência obtidos de pesquisas da atenção pré-natal, exames pré-natais de rotina de detecção precoce e pesquisas da população geral. Casos de SC e desfechos adversos congênitos foram estimados a partir das estimativas de sífilis materna do modelo Spectrum e percentuais de mulheres que fizeram testes de detecção e foram tratadas para sífilis, segundo as definições de casos da Organização Mundial da Saúde (OMS) e probabilidades de risco. Resultados. O modelo Spectrum estimou, para 2016, uma prevalência de gonorreia de 0,70% (intervalo de confiança de 95% [IC 95%] 0,15%–1,9%) no sexo feminino e 0,60% (0,1%–1,9%) no sexo masculino e uma prevalência de clamídia de 9,2% (4,4%–15,4%) no sexo feminino e 7,4% (3,5%–14.7%) no sexo masculino, sem evidência de tendências no período 1995–2016. A prevalência de sífilis ativa em 2016 foi de 1,25% (1,22–1,29%) no sexo feminino e 1,25% (1,1%–1,4%) no sexo masculino, demonstrando um declínio da prevalência de 2,6% (2,1%–3,2%) observada em 1995 para o sexo feminino. Houve, ao todo, 3.851 casos correspondentes de SC em 2016 (incluindo casos assintomáticos), dos quais 2.245 foram desfechos adversos congênitos. Observou-se uma redução nas estimativas anuais de SC e desfechos adversos congênitos em 2008–2016, refletindo a diminuição da prevalência materna e o número crescente de casos evitados com exames pré-natais de detecção e tratamento. Conclusões. Os dados disponíveis de vigilância e monitoramento condensados no modelo Spectrum-STI, e as resultantes estimativas nacionais de infeções sexualmente transmissíveis (IST) obtidas pela primeira vez na Colômbia, evidenciam a alta carga persistente de IST no país. Estima-se que a ocorrência de sífilis do adulto e sífilis congénita esteja diminuindo em decorrência da melhoria nos esforços de detecção precoce. A vigilância reforçada, consistindo também de exames periódicos de detecção precoce nas populações de baixo risco e estimavas futuras aprimoradas do instrumento Spectrum, deve sustentar o planejamento e a implementação de controle e prevenção de IST e a eliminação da SC.