RESUMO
INTRODUCTION: Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute hepatitis in Brazil need to be re-evaluated regarding the different hepatotropic agent (hepatitis A to E virus) frequencies, as well as other agents that can cause similar clinical conditions, such as Herpes Simplex Virus 1 and 2(HSV1, HSV2), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Human Herpes Virus 6 and 7 (HHV6, HHV7), arbovirus (yellow fever, dengue, chikungunya, Zika), parvovirus B19, adenovirus, parechovirus, enterovirus, HIV, leptospirosis, toxoplasmosis and syphilis, in addition to autoimmune hepatitis. In this context, the primary aim of this study is the clinical-epidemiological and molecular characterisation of acute viral hepatitis in Brazilian health services from all geographical regions of the country. The present article describes the study protocol. METHODS AND ANALYSIS: This study will evaluate 2280 patients with symptoms and/or signs suggestive of acute liver disease in Brazilian health institutions in all five geographic Brazilian regions. Demographic, epidemiological and clinical data will be collected, as well as blood samples to be analysed at Hospital Israelita Albert Einstein Clinical Laboratory. ETHICS AND DISSEMINATION: Ethics approval was obtained at the national research ethics committee (Conselho Nacional de Ética em Pesquisa- CONEP-CAAE 00952818.4.1001.0071) and at all participating sites. Results will be published in journals and presented at scientific meetings.
Assuntos
Infecções por Vírus Epstein-Barr , Hepatite Viral Humana , Infecção por Zika virus , Zika virus , Brasil/epidemiologia , Serviços de Saúde , Hepatite Viral Humana/epidemiologia , Herpesvirus Humano 4 , HumanosRESUMO
O diagnóstico de toxoplasmose ocular baseia-se geralmente em dados clinicos e laboratoriais bastante conhecidos. Porém, casos com apresentaçäo clinica atipica ocorrem, principalmente em pacientes imunossuprimidos, trazendo entäo ao médico clinico dificuldades diagnósticas. Os autores descrevem o caso de uma paciente do sexo feminino, com uma doenca ocular bilateral, de tres anos de duracao, em evoluçäo e sem diagnóstico etiológico estabelecido. Após exaustiva investigaçäo clinica e laboratorial e utilizaçäo de vários medicamentos, sem sucesso clinico, optou-se pela enucleaçäo de olho esquerdo, ja atrofico...