Your browser doesn't support javascript.
loading
Study protocol: epidemiological and clinical characteristics of acute viral hepatitis in Brazilian health services.
Sitnik, Roberta; Maluf, Maira Marranghello; Oliveira, Ketti G; Siqueira, Ricardo Andreotti; Ferreira, Carlos Eduardo Dos Santos; Mangueira, Cristóvão Luis Pitangueira; Azevedo, Raymundo Soares; Ferraz, Maria Lucia Cardoso Gomes; Correa, Maria Cassia Jacintho Mendes; Ferreira, Paulo Roberto Abrão; Mendes Pereira, Gerson Fernando; de Souza, Flávia Moreno Alves; Pimenta, Cristina; Pinho, João Renato Rebello.
Afiliação
  • Sitnik R; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Maluf MM; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Oliveira KG; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Siqueira RA; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Ferreira CEDS; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Mangueira CLP; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
  • Azevedo RS; Department of Pathology, LIM01, Universidade de São Paulo Faculdade de Medicina, Sao Paulo, Brazil.
  • Ferraz MLCG; Gastroenterology Division, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
  • Correa MCJM; Department of Infectious and Parasitic Diseases, LIM52, Universidade de São Paulo Faculdade de Medicina, Sao Paulo, Brazil.
  • Ferreira PRA; Infectology Division, Universidade Federal de São Paulo, Sao Paulo, São Paulo, Brazil.
  • Mendes Pereira GF; Department of Chronic Conditions Diseases and Sexually Transmitted Infections, Secretariat for Health Surveillance, Ministry of Health of Brazil, Brasilia, Brazil.
  • de Souza FMA; Department of Chronic Conditions Diseases and Sexually Transmitted Infections, Secretariat for Health Surveillance, Ministry of Health of Brazil, Brasilia, Brazil.
  • Pimenta C; Department of Chronic Conditions Diseases and Sexually Transmitted Infections, Secretariat for Health Surveillance, Ministry of Health of Brazil, Brasilia, Brazil.
  • Pinho JRR; Laboratório de Patologia Clínica e de Anatomia Patológica, Hospital Israelita Albert Einstein, Sao Paulo, Brazil joao.pinho@einstein.br.
BMJ Open ; 11(7): e045852, 2021 07 09.
Article em En | MEDLINE | ID: mdl-34244259
INTRODUCTION: Acute viral hepatitis is a disease of great clinical importance. This study proposes actions to better characterise cases of acute hepatitis in Brazil and to provide relevant information to institutionalised health policies within the Unified Health System. Available data on acute hepatitis in Brazil need to be re-evaluated regarding the different hepatotropic agent (hepatitis A to E virus) frequencies, as well as other agents that can cause similar clinical conditions, such as Herpes Simplex Virus 1 and 2(HSV1, HSV2), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), Epstein Barr Virus (EBV), Human Herpes Virus 6 and 7 (HHV6, HHV7), arbovirus (yellow fever, dengue, chikungunya, Zika), parvovirus B19, adenovirus, parechovirus, enterovirus, HIV, leptospirosis, toxoplasmosis and syphilis, in addition to autoimmune hepatitis. In this context, the primary aim of this study is the clinical-epidemiological and molecular characterisation of acute viral hepatitis in Brazilian health services from all geographical regions of the country. The present article describes the study protocol. METHODS AND ANALYSIS: This study will evaluate 2280 patients with symptoms and/or signs suggestive of acute liver disease in Brazilian health institutions in all five geographic Brazilian regions. Demographic, epidemiological and clinical data will be collected, as well as blood samples to be analysed at Hospital Israelita Albert Einstein Clinical Laboratory. ETHICS AND DISSEMINATION: Ethics approval was obtained at the national research ethics committee (Conselho Nacional de Ética em Pesquisa- CONEP-CAAE 00952818.4.1001.0071) and at all participating sites. Results will be published in journals and presented at scientific meetings.
Assuntos
Palavras-chave
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus Epstein-Barr / Zika virus / Infecção por Zika virus / Hepatite Viral Humana Tipo de estudo: Guideline Aspecto: Ethics Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: BMJ Open Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções por Vírus Epstein-Barr / Zika virus / Infecção por Zika virus / Hepatite Viral Humana Tipo de estudo: Guideline Aspecto: Ethics Limite: Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: BMJ Open Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Brasil País de publicação: Reino Unido