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1.
J Appl Oral Sci ; 25(6): 680-688, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-29211290

RESUMO

OBJECTIVES: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. This study assessed the influence of MC as an anti-washout ingredient and CaCl2 as a setting time accelerator on the physical and biological properties of MTA. MATERIAL AND METHODS: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl2; Group 3: 2% MC/CaCl2. Compressive strength, pH, flowability and cell viability were tested. The gene expression of bone sialoprotein (BSP) was detected by RT-PCR and real- time PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. RESULTS: Compressive strength, pH, and cell viability of MTA mixed with MC/CaCl2 were not significantly different compared to the control group. The flowability of MTA with MC/CaCI2 has decreased significantly when compared to the control (p<.05). The mRNA level of BSP has increased significantly in MTA with MC/CaCl2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl2 compared to the control (p<.05). CONCLUSIONS: MC decreased the flowability of MTA and did not interrupt the physical and biological effect of MTA. It suggests that these cements may be useful as a root-end filling material.


Assuntos
Compostos de Alumínio/química , Compostos de Alumínio/farmacologia , Cloreto de Cálcio/farmacologia , Compostos de Cálcio/química , Compostos de Cálcio/farmacologia , Metilcelulose/farmacologia , Óxidos/química , Óxidos/farmacologia , Materiais Restauradores do Canal Radicular/química , Silicatos/química , Silicatos/farmacologia , Animais , Células Cultivadas/efeitos dos fármacos , Força Compressiva , Polpa Dentária/efeitos dos fármacos , Combinação de Medicamentos , Teste de Materiais , Camundongos
2.
J. appl. oral sci ; J. appl. oral sci;25(6): 680-688, Nov.-Dec. 2017. tab, graf
Artigo em Inglês | LILACS, BBO - Odontologia | ID: biblio-893667

RESUMO

Abstract Objectives: Methylcellulose (MC) is a chemical compound derived from cellulose. MTA mixed with MC reduces setting time and increases plasticity. This study assessed the influence of MC as an anti-washout ingredient and CaCl2 as a setting time accelerator on the physical and biological properties of MTA. Material and Methods: Test materials were divided into 3 groups; Group 1(control): distilled water; Group 2: 1% MC/CaCl2; Group 3: 2% MC/CaCl2. Compressive strength, pH, flowability and cell viability were tested. The gene expression of bone sialoprotein (BSP) was detected by RT-PCR and real­ time PCR. The expression of alkaline phosphatase (ALP) and mineralization behavior were evaluated using an ALP staining and an alizarin red staining. Results: Compressive strength, pH, and cell viability of MTA mixed with MC/CaCl2 were not significantly different compared to the control group. The flowability of MTA with MC/CaCI2 has decreased significantly when compared to the control (p<.05). The mRNA level of BSP has increased significantly in MTA with MC/CaCl2 compared to the control (p<.05). This study revealed higher expression of ALP and mineralization in cells exposed to MTA mixed with water and MTA mixed with MC/CaCl2 compared to the control (p<.05). Conclusions: MC decreased the flowability of MTA and did not interrupt the physical and biological effect of MTA. It suggests that these cements may be useful as a root-end filling material.


Assuntos
Animais , Camundongos , Óxidos/farmacologia , Óxidos/química , Materiais Restauradores do Canal Radicular/química , Cloreto de Cálcio/farmacologia , Silicatos/farmacologia , Silicatos/química , Compostos de Cálcio/farmacologia , Compostos de Cálcio/química , Compostos de Alumínio/farmacologia , Compostos de Alumínio/química , Metilcelulose/farmacologia , Teste de Materiais , Células Cultivadas/efeitos dos fármacos , Força Compressiva , Polpa Dentária/efeitos dos fármacos , Combinação de Medicamentos
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