RESUMO
UNLABELLED: The objective of this study was to know the prognostic value of estrogen receptors and progesterone receptors positives (ER+, PR+) in the management of low grade squamous intraepithelial lesions [(LGSIL), human papillomavirus (HPV) and cervical intraepithelial neoplasia grade 1 (CIN 1) and menopausal status]. MATERIAL AND METHODS: From January 1995 to January of 1999, was studied in 144 women with abnormal citology to HPV and CIN grades 1, 2 or 3. Colposcopy was carried out and two biopsies were taken from the suspicious lesion, they were sent for histopathological study, and for ER/PR by the dextran-coated charcoal technique. In addition to the receptor status information, histological type of squamous intraepithelial lesions (SIL), and menopausal status were recorded and analyzed and were correlated later. RESULTS: In normal cervix, 89% and 60% of specimens were ER+, PR+ (+6 fmol/mg protein) There was significant difference in ER status between the normal cervix con HPV and CIN, (P < 0.003), but no with PR (P > 0.53). ER levels in premenopausal and postmenopausal patients there was no significant difference (P > 0.27) but PR levels there was significant difference (P < 0.04). ER/PR levels in HPV o CIN grade no correlated to the histologic grade and menopausal status (P > 0.35, > 0.97, respectively). CONCLUSION: The women with levels ER+ were significant higher in the normal cervix than SIL, ER+, PR+ levels no correlated to the prognostic value in the management of LGSIL and menopausal status.
Assuntos
Receptores de Estrogênio/análise , Receptores de Progesterona/análise , Displasia do Colo do Útero/química , Neoplasias do Colo do Útero/química , Adolescente , Adulto , Idoso , Feminino , Humanos , Menopausa , Pessoa de Meia-Idade , Estadiamento de Neoplasias , Papillomaviridae , Infecções por Papillomavirus/complicações , Prognóstico , Infecções Tumorais por Vírus/complicações , Neoplasias do Colo do Útero/patologia , Neoplasias do Colo do Útero/virologia , Displasia do Colo do Útero/patologia , Displasia do Colo do Útero/virologiaRESUMO
The purpose of this study was to compare the results of conservative management with cryosurgery and with hysterectomy in different stages of NIC. The records of 235 treated patients from 1984 to 1991, were reviewed; 140 patients were treated with cryosurgery and 95 with total hysterectomy. Cure rate was for stage I in 34 patients (94.5); for stage II in 54 patients (98.2%), and for stage III in 46 patients (93.9%). For hysterectomy in NIC I in 5 patients (100%); for NIC II in 15 (100%), and for NIC III in 74 (98.66%). Statistical study with square Chi showed a not significant P which means that there is no difference in the results of Cure and No Cure in both procedures. It is concluded that intraepithelial cervical neoplasia may be managed with both procedures, provided that the established criteria for cryosurgery and hysterectomy, are followed.