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[Value of estrogen and progesterone receptors in the management of intraepithelial squamous lesions of low grade]. / Valor de los receptores a estrógeno y a progesterona en el manejo de las lesiones escamosas intraepiteliales de bajo grado.
González Sánchez, J L; Chávez Brambila, J; Maricela Román, A; Infante Martínez, R; Salazar Esquivel, L E.
Afiliação
  • González Sánchez JL; Instituto Mexicano del Seguro Social, Hospital de Gineco-Obstetricia Luis Castelazo Ayala.
Ginecol Obstet Mex ; 69: 1-5, 2001 Jan.
Article em Es | MEDLINE | ID: mdl-11268728
UNLABELLED: The objective of this study was to know the prognostic value of estrogen receptors and progesterone receptors positives (ER+, PR+) in the management of low grade squamous intraepithelial lesions [(LGSIL), human papillomavirus (HPV) and cervical intraepithelial neoplasia grade 1 (CIN 1) and menopausal status]. MATERIAL AND METHODS: From January 1995 to January of 1999, was studied in 144 women with abnormal citology to HPV and CIN grades 1, 2 or 3. Colposcopy was carried out and two biopsies were taken from the suspicious lesion, they were sent for histopathological study, and for ER/PR by the dextran-coated charcoal technique. In addition to the receptor status information, histological type of squamous intraepithelial lesions (SIL), and menopausal status were recorded and analyzed and were correlated later. RESULTS: In normal cervix, 89% and 60% of specimens were ER+, PR+ (+6 fmol/mg protein) There was significant difference in ER status between the normal cervix con HPV and CIN, (P < 0.003), but no with PR (P > 0.53). ER levels in premenopausal and postmenopausal patients there was no significant difference (P > 0.27) but PR levels there was significant difference (P < 0.04). ER/PR levels in HPV o CIN grade no correlated to the histologic grade and menopausal status (P > 0.35, > 0.97, respectively). CONCLUSION: The women with levels ER+ were significant higher in the normal cervix than SIL, ER+, PR+ levels no correlated to the prognostic value in the management of LGSIL and menopausal status.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Progesterona / Receptores de Estrogênio / Displasia do Colo do Útero / Neoplasias do Colo do Útero Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: Es Revista: Ginecol Obstet Mex Ano de publicação: 2001 Tipo de documento: Article País de publicação: México
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores de Progesterona / Receptores de Estrogênio / Displasia do Colo do Útero / Neoplasias do Colo do Útero Tipo de estudo: Prognostic_studies Limite: Adolescent / Adult / Aged / Female / Humans / Middle aged Idioma: Es Revista: Ginecol Obstet Mex Ano de publicação: 2001 Tipo de documento: Article País de publicação: México