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Objetivo: Analisar os fatores relacionados à COVID longa na população adulta do Brasil. Métodos: Estudo transversal analítico, do tipo web-survey, com abordagem quantitativa. A amostragem foi não probabilística, do tipo intencional, e incluiu 228 adultos brasileiros que testaram positivo para COVID-19. A coleta de dados ocorreu por meio de questionário online. Para verificar a associação entre variáveis qualitativas, utilizou-se o Teste Qui-quadrado ou Teste Exato de Fisher e, nas quantitativas, aplicou-se o Teste de Mann-Whitney com significância de 0,05. Resultados: Constatou-se que houve associação de variáveis sociodemográficas com a COVID longa. Observa-se maior média de idade entre aqueles em que persistiram os sintomas (p=0,041). A renda familiar daqueles com sintomas persistentes era inferior à dos indivíduos sem persistência (p=0,005). A prática de atividade física esteve associada a não persistência dos sintomas (p=0,024). A hipertensão arterial foi a comorbidade mais prevalente naqueles com sintomas persistentes (5,9%). No quadro clínico de COVID-19 associado à persistência dos sintomas, identificam-se calafrios (p-valor=0,009), cefaleia (p-valor=0,0027), tosse (p-valor=0,000), anosmia (p-valor=0,048), ageusia (p-valor=0,013), dispneia (p-valor=0,000) e diarreia (p-valor=0,018). sintoma de COVID longa mais prevalente foi a fadiga (62,89%). Conclusão: Idade e renda estiveram associadas à COVID longa. Praticar atividade física esteve associado a não persistência de sintomas. Descritores: COVID-19;COVID Longa; Sinais e Sintomas;Fatores de Risco; Brasil.

Objective:To analyze the factors related to long COVID in the adult population of Brazil. Methods:Analytical cross-sectional study, web-survey type, with quantitative approach. The sampling was non-probabilistic, of the intentional type, including 228 Brazilian adults who tested positive for COVID-19. Data collection took place through an online questionnaire. To verify the association between qualitative variables, the Chi-square test or Fisher's exact test was used and, in quantitative variables, the Mann-Whitneytest was applied with significance of 0.05.Results:It was observed that there was an association of sociodemographic variables with long COVID. A higher mean age was observed among those who persisted symptoms (p=0.041). The family income of those with persistent symptoms was lower than that of individualswithout persistence (p=0.005). The practice of physical activity was associated with the non-persistence of symptoms (p=0.024). Arterial hypertension was the most prevalent comorbidity in those with persistent symptoms (5.9%). In the clinical picture of COVID-19 associated with the persistence of symptoms, it is observed: chills (p-value=0.009), headache (p-value=0.0027), cough (p-value=0.000), anosmia (p-value=0.048), ageusia (p-value=0.013), dyspnea (p-value=0.000) and diarrhea (p-value=0.018). The most prevalent long COVID symptom was fatigue (62.89%).Conclusion:Age and income were associated with long COVID. Physical activity was associated with no persistence of symptoms. Descriptors: COVID-19; Long Covid; Signs and Symptoms; Risk Factors; Brazil

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This study aimed to investigate the level of lipid and protein oxidation in poultry breasts with severe white striping (WS; striation thickness > 1 mm) and nonaffected meats (N; normal breast) during storage under refrigeration (1°C for 14 d) and freezing (-18°C for 90 d). WS presented higher lipid content, although no difference in protein content was detected, compared to normal broiler breast (N). Regarding oxidative damages, a reduction in malondialdehyde and carbonyl protein, hexanal, octanal and nonanal levels, alongside the interaction of these compounds with other compounds in raw, roasted, and reheated breasts was observed under refrigerated storage (14 d). Freezing storage promotes an increase in carbonyls proteins, hexanal, octanal and nonanal levels at 45 d of storage in poultry meats and subsequent decrease, indicating the evolution of oxidative reactions. Regardless of the type of storage, in general, breasts with WS myopathy have higher levels of lipid and protein oxidation.

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The virulence of Cryptococcus spp. is modulated in the natural environment through interaction with abiotic and biotic factors, and this can occasionally have implications for the progression of cryptococcosis in mammals. Hence, we evaluated whether the prior interaction of highly virulent Cryptococcus gattii strain R265 with Acanthamoeba castellanii influenced the progression of cryptococcosis. The influence of the capsule on endocytosis was evaluated using amoeba and yeast morphometrics. Mice were intratracheally infected with yeast re-isolated from the amoeba (Interaction), yeast without prior contact with the amoeba (Non-Interaction), or sterile phosphate-buffered saline (SHAM). Morbidity signs and symptoms were monitored during the survival curve, while cytokine and fungal burden measurements and histopathological analysis were performed on the 10th day post infection. Morbidity and mortality parameters in experimental cryptococcosis were influenced by the prior interaction of yeast with amoeba, which led to phenotypic changes in the cryptococcal cells, polysaccharide secretion, and their tolerance to oxidative stress. Our results suggest that a prior yeast-amoeba interaction modulates yeast virulence, which is associated with a greater tolerance to oxidative stress related to the exo-polysaccharide content and influences the progression of cryptococcal infection.

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Trata-se de um relato de experiência que objetivou descrever a vivência de acadêmicos de enfermagem na utilização de uma tecnologia educativa para abordagem da alimentação de hipertensos e diabéticos paraenses. Utilizou-se um painel interativo com figuras de alimentos presentes no cotidiano da população, algumas relacionadas a alimentos capazes de contribuir para o descontrole das doenças e outras com alimentos substitutivos, mais saudáveis e capazes de exercer papel positivo e efeito protetor. Observou-se que a ação centrada na adaptação e nas sugestões de substituições mais saudáveis com diminuição da quantidade ou substituições por alimentos regionais mostrou-se positiva, uma vez que estimulou o senso de pertencimento cultural e a autonomia do participante e que a elaboração de planos de cuidado devem ser personalizados em respeito às diferenças regionais e culturais.

This is an experience report that aimed to describe the experience of nursing students in the use of educational technology to approach the feeding of hypertensive and diabetic patients from Pará. An interactive panel was used with pictures of foods present in the population's daily life, some related to foods capable of contributing to the lack of control of diseases, and others with substitute foods, healthier and capable of exerting a positive role and protective effect. It was observed that the action centered on adaptation and suggestions for healthier replacements, with a reduction in the quantity or substitutions for regional foods, proved to be positive, as it stimulated the participant's sense of cultural belonging and autonomy and the development of care plans must be personalized with respect for regional and cultural differences.

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OBJETIVO: analisar o perfil sociodemográfico e a tendência da mortalidade por infarto agudo miocárdio no Nordeste do Brasil entre os anos de 2011 a 2021. MÉTODOS: estudo ecológico que utilizou dados do Sistema de Informação sobre Mortalidade. Foram calculadas as taxas de mortalidade para o sexo dos indivíduos e estados da região nordestina. Para análise temporal foi utilizado o software Joinpoint. RESULTADOS: a maioria dos óbitos ocorreu entre homens (57,02%), pardos (60,81%) e idosos (76,22%). As médias da taxa de mortalidade foram elevadas nos homens acima dos 80 anos de idade (234,74 óbitos por 100 mil habitantes). Observou-se maiores tendências de aumento significativos de 3,8% e 3,2% ao ano da mortalidade por infarto em Alagoas e Bahia, respectivamente. CONCLUSÃO: entre os anos de 2011 a 2021 o infarto do miocárdio acometeu homens, idosos, da cor parda. Houve maior tendência de aumento nos estados de Alagoas e Bahia durante todo o período estudado. O estudo contribui para o direcionamento de políticas que identifique fatores de risco e elabore intervenções preventivas efetivas, investindo em diagnóstico precoce, programas de prevenção e promoção de saúde.

OBJECTIVE: to analyze the sociodemographic profile and temporal trend of acute myocardial infarction mortality in Northeast Brazil from 2011 to 2021. METHODS: this ecological study utilized data from the Mortality Information System. Mortality rates were calculated based on gender and states within the Northeast region. The Joinpoint software was used for temporal analysis. RESULTS: the majority of deaths occurred among males (57.02%), individuals of mixed race (60.81%), and elderly individuals (76.22%). The average mortality rate was highest among men above 80 years of age (234.74 deaths per 100,000 inhabitants). Significant increasing trends of 3.8% and 3.2% per year were observed for myocardial infarction mortality in Alagoas and Bahia, respectively. CONCLUSION: between 2011 and 2021, myocardial infarction predominantly affected elderly, male individuals of mixed race. Alagoas and Bahia showed the highest increasing trends in mortality throughout the study period. The study contributes to guiding policies that identify risk factors and develop effective preventive interventions, emphasizing early diagnosis, prevention programs, and health promotion. KEYWORDS: Myocardial Infarction; Mortality; Epidemiology; Time Series Studies.

OBJETIVO: Analizar el perfil sociodemográfico y la tendencia temporal de la mortalidad por infarto agudo de miocardio en el Noreste de Brasil entre los años 2011 y 2021. MÉTODOS: Este estudio ecológico utilizó datos del Sistema de Información sobre Mortalidad. Se calcularon tasas de mortalidad según el sexo de los individuos y los estados dentro de la región nordestina. Para el análisis temporal, se utilizó el software Joinpoint. RESULTADOS: La mayoría de los fallecimientos ocurrieron entre hombres (57,02%), individuos de raza mestiza (60,81%) y personas de edad avanzada (76,22%). La tasa media de mortalidad fue más alta en hombres mayores de 80 años (234,74 muertes por 100 mil habitantes). Se observaron tendencias significativamente crecientes del 3,8% y el 3,2% por año en la mortalidad por infarto en Alagoas y Bahía, respectivamente. CONCLUSIÓN: Entre 2011 y 2021, el infarto de miocardio afectó principalmente a hombres de edad avanzada, de raza mestiza. Alagoas y Bahía mostraron las tendencias crecientes más altas en mortalidad durante todo el período de estudio. El estudio contribuye a orientar políticas que identifiquen factores de riesgo y desarrollen intervenciones preventivas efectivas, haciendo hincapié en el diagnóstico temprano, programas de prevención y promoción de la salud.

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Objetivo: Relatar a experiência vivenciada no encontro sobre a saúde da população indígena Tapeba. Métodos: Trata-se de um estudo descritivo com abordagem qualitativa sobre a Mesa-Redonda intitulada Os problemas vivenciados pelos portadores de Diabetes Mellitus e Hipertensão Arterial Crônica, realizada com profissionais atuantes junto a etnia, pesquisadores e representantes da população indígena Tapeba, Caucaia-Ceará, que ocorreu no Auditório da Escola de Saúde Pública do Ceará, em julho de 2022, com intuito de conhecer as narrativas cotidianas, mesclar saberes tradicional e científico e apreender sobre as Doenças Crônicas Não Transmissíveis (DCNT). Resultados: Participaram do encontro 22 profissionais de distintas áreas da saúde, observando-se que durante o encontro suscitou diferentes efeitos nos participantes, que se destacaram em três grandes categorias, a saber: 1)motivação de fala, 2) interação e representatividade com os temas ministrados, e 3) insegurança alimentar. Conclusão: O estudo demonstra que as DCNT configuram um problema de saúde em avanço entre as populações indígenas. Representantes do povo Tapeba puderam expor, para além do reconhecimento destes agravos na comunidade, a dificuldade encontrada em apreender as informações recebidas e aderir às orientações, além dos efeitos da pobreza, representadas na insegurança alimentar e desemprego. PALAVRAS-CHAVE: Povos Indígenas; Doenças Crônicas Não Transmissíveis; Pobreza; Insegurança Alimentar.

Objective: To report the experience of the meeting on the health of the indigenous population Tapeba. Methods: This is a descriptive study with a qualitative approach on the Round Table entitled The problems experienced by the sufferers of Diabetes Mellitus and Chronic Arterial Hypertension, carried out with professionals working with the ethnicity, researchers and representatives of the indigenous population Tapeba, Caucaia-Ceará, which took place at the Auditorium of the School of Public Health of Ceará, in July 2022, with the aim of knowing the daily narratives, merging traditional and scientific knowledge and learning about the Chronic Non-Communicable Diseases (CNCDs). Results: 22 professionals from different areas of health participated in the meeting, observing that during the meeting it produced different effects in the participants, which stood out in three major categories, namely: 1)speech motivation, 2) interaction and representativeness with the topics administered, and 3) food insecurity. Conclusion: The study shows that CNCDs are an ongoing health problem among indigenous populations. Representatives of the Tapeba people were able to explain, in addition to recognising these problems in the community, the difficulty they encountered in learning the information received and adhering to the guidelines, as well as the effects of poverty, represented in food insecurity and unemployment.

Propósito: Informar sobre la experiencia de la reunión sobre la salud de la población indígena Tapeba. Métodos: Se trata de un estudio descriptivo con un enfoque cualitativo en la Mesa Redonda titulada Los problemas experimentados por los portadores de diabetes mellitus e hipertensión arterial crónica, realizado con profesionales que trabajan con la etnia, investigadores y representantes de la población indígena Tapeba, Caucaia-Ceará, que tuvo lugar en el Auditorio de la Escuela de Salud Pública de Ceará, en julio de 2022, con el fin de conocer las narrativas cotidianas, fusionar los conocimientos tradicionales y científicos y aprender sobre la Diversidad Crónica No Transmisible (NSTD). Resultados: 22 profesionales de la salud asistieron a la reunión, señalando que durante la reunión se sintieron diferentes efectos en los participantes, que destacaron en tres grandes categorías, a saber: 1) motivación del discurso, 2) interacción y representatividad con los temas dados, y 3) inseguridad alimentaria. Conclusión: El estudio muestra que los DCNT constituyen por adelantado un problema de salud entre las poblaciones indígenas. Los representantes del pueblo Tapeba han podido explicar, además del reconocimiento de estas agravaciones en la comunidad, las dificultades encontradas para obtener la información recibida y adherirse a las directrices, así como los efectos de la pobreza, representadas en la inseguridad alimentaria y el desempleo.

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Glanders is a contagious zoonotic infectious disease characterized by an acute or chronic condition that mainly affects equids and is caused by Burkholderia (B.) mallei. From January 2005 to December 2017, 697 farms with positive cases of this disease were registered in Brazil, with the Northeast region accounting for 61.4% (428/697) of the total number of cases. This study conducted an epidemiological study of B. mallei infections that occurred in farms in the states of Pernambuco, Paraíba, Ceará and Alagoas. For this purpose, investigative questionnaires were applied to six farms where there were outbreaks of glanders and 11 farms where there were no reports of glanders between 2017 and 2021, and statistical analysis of the factors associated with the occurrence of glanders in Northeastern Brazil was performed. Factors such as the purpose of rearing (P = 0.023), lack of information on disease transmission modes (P = 0.034), failure to carry out periodic tests for glanders diagnosis (P = 0,029), no request for glanders tests prior to the purchase of new animals periodic tests for glanders diagnosis (P = 0.029), not requiring a negative test for glanders in the acquisition of animals (P = 0.06), use of extensive breeding systems(P = 0.027), and poor stall hygiene were associated with disease occurrence (P = 0.001). Understanding the factors related to the occurrence of glanders in the Northeast Region of Brazil helps to establish management measures that minimize bacteria transmission, thereby reducing the number of cases in the region and economic losses associated with glanders.

O mormo é uma doença infectocontagiosa, zoonótica, de caráter agudo ou crônico, que acomete principalmente os equídeos, causado por Burkholderia (B.) mallei. De janeiro de 2005 até dezembro de 2017, 697 focos da doença foram registrados no Brasil, sendo que a região Nordeste detém 61,4% (428/697) do total de focos. Objetivou-se realizar um estudo epidemiológico da infecção por Burkholderia mallei em propriedades nos estados de Pernambuco, Paraíba, Ceará e Alagoas. Para tal foi aplicado questionário investigativo em seis fazendas onde houve caso de Mormo e 11 fazendas em que não houve relato entre 2007 e 2011 e realizada análise estatística dos fatores de manejo associados à ocorrência do Mormo no Nordeste do Brasil. Observou-se associação significativa para as seguintes variáveis: objetivo da criação (comércio, esporte e trabalho nas fazendas) (P = 0,023); ausência de informação sobre as formas de transmissão da bactéria (P = 0,034); não realização de exames periódicos para o diagnóstico do mormo (P = 0,029); exigência de exame negativo na compra de equinos (P = 0,06); utilização do sistema de criação extensivo (P = 0,027) e deficiência de higienização das baias (P = 001). Os resultados obtidos devem ser utilizados na implementação de medidas de manejo que minimizem o risco de transmissão da bactéria, reduzindo os casos da doença na região e as perdas econômicas com o mormo.

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ABSTRACT: Glanders is a contagious zoonotic infectious disease characterized by an acute or chronic condition that mainly affects equids and is caused by Burkholderia (B.) mallei. From January 2005 to December 2017, 697 farms with positive cases of this disease were registered in Brazil, with the Northeast region accounting for 61.4% (428/697) of the total number of cases. This study conducted an epidemiological study of B. mallei infections that occurred in farms in the states of Pernambuco, Paraíba, Ceará and Alagoas. For this purpose, investigative questionnaires were applied to six farms where there were outbreaks of glanders and 11 farms where there were no reports of glanders between 2017 and 2021, and statistical analysis of the factors associated with the occurrence of glanders in Northeastern Brazil was performed. Factors such as the purpose of rearing (P = 0.023), lack of information on disease transmission modes (P = 0.034), failure to carry out periodic tests for glanders diagnosis (P = 0,029), no request for glanders tests prior to the purchase of new animals periodic tests for glanders diagnosis (P = 0.029), not requiring a negative test for glanders in the acquisition of animals (P = 0.06), use of extensive breeding systems(P = 0.027), and poor stall hygiene were associated with disease occurrence (P = 0.001). Understanding the factors related to the occurrence of glanders in the Northeast Region of Brazil helps to establish management measures that minimize bacteria transmission, thereby reducing the number of cases in the region and economic losses associated with glanders.

RESUMO: O mormo é uma doença infectocontagiosa, zoonótica, de caráter agudo ou crônico, que acomete principalmente os equídeos, causado por Burkholderia (B.) mallei. De janeiro de 2005 até dezembro de 2017, 697 focos da doença foram registrados no Brasil, sendo que a região Nordeste detém 61,4% (428/697) do total de focos. Objetivou-se realizar um estudo epidemiológico da infecção por Burkholderia mallei em propriedades nos estados de Pernambuco, Paraíba, Ceará e Alagoas. Para tal foi aplicado questionário investigativo em seis fazendas onde houve caso de Mormo e 11 fazendas em que não houve relato entre 2007 e 2011 e realizada análise estatística dos fatores de manejo associados à ocorrência do Mormo no Nordeste do Brasil. Observou-se associação significativa para as seguintes variáveis: objetivo da criação (comércio, esporte e trabalho nas fazendas) (P = 0,023); ausência de informação sobre as formas de transmissão da bactéria (P = 0,034); não realização de exames periódicos para o diagnóstico do mormo (P = 0,029); exigência de exame negativo na compra de equinos (P = 0,06); utilização do sistema de criação extensivo (P = 0,027) e deficiência de higienização das baias (P = 001). Os resultados obtidos devem ser utilizados na implementação de medidas de manejo que minimizem o risco de transmissão da bactéria, reduzindo os casos da doença na região e as perdas econômicas com o mormo.

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As vulnerabilidades inerentes ao processo de envelhecimento tornam os cidadãos longevos grupo de risco no contágio ao SARS-CoV-2. O sistema imunológico sofre com o envelhecer, a denominada imunossenescência, em que ocorre redução na capacidade de resposta a infecções, promovendo o aumento de contaminação e gravidade de doenças infectocontagiosas. Assim, muitas são as incertezas acerca desse contexto pandêmico para a população idosa, por apresentar maior vulnerabilidade às formas graves da doença e maior risco de morrer, em especial idosos frágeis, portadores de comorbidades e residentes de Instituições de Longa Permanência para Idosos (ILPIs). Contudo, são observados significativos impactos que a COVID-19 tem provocado na saúde e qualidade de vida do idoso. Prejuízos ocasionados pelo isolamento social sobre a saúde mental, fatores socioeconômicos como redução da renda e a evidência do ageísmo. Entretanto, as consequências orgânicas causadas nos idosos, no chamado pós COVID, tem demandado uma nova configuração de cuidado para essa parcela populacional.

The vulnerabilities inherent to the aging process make long-lived citizens a risk group for contagion to SARS-CoV-2. The immune system suffers with aging, the so-called immunosenescence, in which there is a reduction in the capacity to respond to infections, promoting an increase in contamination and severity of infectious diseases. Thus, there are many uncertainties about this pandemic context for the elderly population, as they are more vulnerable to severe forms of the disease and a greater risk of dying, especially frail elderly people, patients with comorbidities and residents of Long-stay Institutions for the Elderly people (LIEPs). However, there are significant impacts that COVID-19 has had on the health and quality of life of the elderly people. Losses caused by social isolation on mental health, socioeconomic factors such as reduced income and evidence of ageism. However, the organic consequences caused in seniors, in the so-called post-COVID, have demanded a new configuration of care for this portion of the population.

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Objetivo:Identificar e descrever a prevalência de casos de COVID-19 entre profissionais de saúde.Métodos:Estudo transversal descritivo,realizado entreprofissionais de saúdeatuantes na assistência,independente se teve ou não a doença. A coleta de dados ocorreu de forma online,adotando-se a técnica de bola de neve. Realizou-se análise descritiva dos resultados.Resultados:Aamostra foi composta por128 profissionais de saúde. A prevalência geral foi de 46,9%. Nalinha de frente,a prevalência foi de 61,7%. A mediana de idades foi de 30 anos. Enfermeiros (61,7%) etécnicos de enfermagem (20%) tiverammais diagnósticos. A obesidade foi a condição de saúde mais prevalente nos que tiveram COVID-19 (20%). Houve uso de profilaxia para a COVID-19 com ivermectina (55,0%), azitromicina (43,3%) e hidroxicloroquina (3,1%), participação em aglomeração externo ao trabalho (50%), contato com familiar positivo(51,7%),higienização das mãos apenas com o álcool em gel (60,0%)e falta de equipamentos de proteção individual (43,3%).Conclusão:Houve uma elevada prevalência de casos,especialmentenos profissionais dalinha de frente, assim como elevada frequência depráticas de risco para a doença, como aglomerações, excesso de jornada de trabalho, uso de profilaxia e problemas com os Equipamentos de Proteção Individual.

Objective:To identify and describe the prevalence of COVID-19 cases among health professionals. Methods:Adescriptive cross-sectional study, carried out among health professionals working in care, regardless of whether or not they had the disease. Data collection took place online, using the snowball technique. A descriptive analysis of the results was performed. Results:The sample consisted of 128 health professionals. The overall prevalence was 46.9%. On the front line, the prevalence was 61.7%. Themedian age was 30 years. Nurses (61.7%) and nursing technicians (20%) had more diagnoses. Obesity was the most prevalent health condition in those who had COVID-19 (20%). There was prophylaxis use for COVID-19 with ivermectin (55.0%), azithromycin (43.3%)and hydroxychloroquine (3.1%), participation in crowds outside work (50%), contact with a positive family member (51.7%), hand hygiene only with gel alcohol (60.0%) and lack of personal protective equipment (43.3%).Conclusion:There was a high prevalenceof cases, especially among frontline professionals, as well as a high frequency of risky practices for the disease, such as crowds, excessive working hours, prophylaxis use and problems with Personal Protective Equipment

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OBJECTIVES: to report the experience on the operationalization of a university extension project with and for training affirmative action students. METHODS: an experience report with a descriptive approach on the operationalization of a university extension project for training affirmative action students, between 2020 and 2021, based on blended-learning and Activity Theory. RESULTS: we carried out 103 activities, including actions for product development, media maintenance and targeted study of themes. They involved 13 students from two institutions, two leaders from ethnic groups and eight instructors. FINAL CONSIDERATIONS: collaborative relationships provided the exchange of knowledge about public health policies, educational technologies and social media, reducing deficits in the use of technological resources and application in health education. The activities promoted students' leading role coming from affirmative action, in a representative way, from their experiences and needs, being potential for equitable training.

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A hipertensão arterial (HA) é uma doença que atinge crianças e adolescentes e sua identificação, cada vez mais cedo, contribui para evitar o desenvolvimento precoce das doenças cardiovasculares. O objetivo deste trabalho foi verificar a presença de pressão arterial (PA) acima da normalidade e relacionar com obesidade e estilo de vida de escolares das cidades de Bauru, Ibitinga, Jaú e São Sebastião. Foram avaliadas 369 crianças e adolescentes. Informações sobre saúde e prática de exercícios físicos foram obtidas pela anamnese. Após cinco minutos de repouso, foram realizadas avaliações hemodinâmicas e antropométricas em cada participante. Taxa de Odds foi usada para avaliar o risco de pressão arterial acima da normalidade em crianças com peso alterado e inativas. Correlação de Pearson foi usada para correlacionar as variáveis antropométricas e hemodinâmicas. Dentre os avaliados, 28% apresentaram valores alterados de PA e 29% já estavam com sobrepeso e obesidade. Além disso, 89% dos escolares foram classificados como insuficientemente ativos. Dentre os escolares com sobrepeso, 48% estavam com a PA alterada e, dentre os obesos a PA estava alterada em 65%. Crianças e adolescentes com peso acima do normal apresentavam 3,59 vezes mais chances de apresentar PA alterada. Pode-se concluir que os resultados são de extrema relevância para reforçar a inclusão de diferentes estratégias nas escolas para o controle da obesidade e sedentarismo desde a infância, a fim de se evitar casos precoces de hipertensão e doenças cardiovasculares.

Arterial hypertension (AH) is a disease that affects children and adolescents and its identification, helps to prevent the premature development of cardiovascular diseases. The objective of this study was to verify the presence of blood pressure (BP) above normal and to relate it to obesity and lifestyle of scholars in the cities of Bauru, Ibitinga, Jaú and São Sebastião. A total of 369 children and adolescents were evaluated. Information on health and physical exercise were obtained through anamnesis. After 5 minutes of rest, hemodynamic and anthropometric assessments were performed on each participant. Odds rate was used to assess the risk of above-normal blood pressure in overweight and inactive children. Pearson's correlation was used to correlate anthropometric and hemodynamic variables. Among those evaluated, 28% had altered BP values and 29% were already overweight and obese. In addition, 89% of students were classified as insufficiently active. Among overweight scholars, 48% had altered BP and, among obese, BP was altered in 65%. Overweight children and adolescents had 3.59 times more risk to have altered BP. It can be concluded that the results are extremely relevant to reinforce the inclusion of different strategies in schools for the control of obesity and sedentary lifestyle, in order to avoid early cases of hypertension and cardiovascular diseases.

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Background: Allergic asthma is a chronic lung disease in which the lung inflammation and airway remodeling are orchestrated by both the inflammatory and the immune cells that creates a lung millieu that favors the perpetuation of clinical symptoms. The cell signaling in asthma involves the mast cells activation during initial contact with the allergen and, principally, the participation of eosinophils as well as Th2 cells which determine increased levels of IgE, exaggerated secretion of mucus and collagen, and bronchial hyperreactivity. Moreover, allergic asthma presents lower level of cytokines associated to the both Th1 and Treg cells response, and it implies in deficiency of anti-inflammatory response to counterregulate the exaggerated inflammation against allergen. Therefore, the equilibrium between cytokines as well as transcription factors associated to Th2, Th1, and Treg cells is compromised in allergic asthma. Imuno TF® is a food supplement with ability to interfere in immune system pathways. It has been previously demonstrated that Imuno TF® upregulated Th1 cell response whilst downregulated Th2 cell response in human lymphocytes. Objective: For this reason, we hypothesized that the Imuno TF effect could be restore the balance between Th1/Th2 CD4 T cells response in murine allergic asthma. Methods: Initially, animals were sensitized with OVA via i.p. and challenged with OVA i.n. on days 14, 15 and 16. Treatment with Imuno TF once a day was performed via orogastric from day 17 to day 20. Mice were euthanized on day 21. Results: The Imuno TF reduced eosinophilia, mucus production, and airway remodeling (collagen deposition) in asthma mice. Imuno TF influenced cellular signaling associated to allergic asthma once downregulated STAT6 expression as well as decreased IL-4, IL-5, and IL-13 in lung and serum. In addition, Imuno TF restored T-bet and Foxp3 expression as well as increased IL-12, IFN-É£, and IL-10. Conclusion: Ultimately, Imuno TF mitigated the allergic asthma due to the restoration of balance between the responses of Th1/Th2 as well as Treg cells, and their respective transcription factors the T-bet/STAT6 and Foxp3.

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A hipertensão arterial (HA) é uma doença que atinge crianças e adolescentes e sua identificação, cada vez mais cedo, contribui para evitar o desenvolvimento precoce das doenças cardiovasculares. O objetivo deste trabalho foi verificar a presença de pressão arterial (PA) acima da normalidade e relacionar com obesidade e estilo de vida de escolares das cidades de Bauru, Ibitinga, Jaú e São Sebastião. Foram avaliadas 369 crianças e adolescentes. Informações sobre saúde e prática de exercícios físicos foram obtidas pela anamnese. Após cinco minutos de repouso, foram realizadas avaliações hemodinâmicas e antropométricas em cada participante. Taxa de Odds foi usada para avaliar o risco de pressão arterial acima da normalidade em crianças com peso alterado e inativas. Correlação de Pearson foi usada para correlacionar as variáveis antropométricas e hemodinâmicas. Dentre os avaliados, 28% apresentaram valores alterados de PA e 29% já estavam com sobrepeso e obesidade. Além disso, 89% dos escolares foram classificados como insuficientemente ativos. Dentre os escolares com sobrepeso, 48% estavam com a PA alterada e, dentre os obesos a PA estava alterada em 65%. Crianças e adolescentes com peso acima do normal apresentavam 3,59 vezes mais chances de apresentar PA alterada. Pode-se concluir que os resultados são de extrema relevância para reforçar a inclusão de diferentes estratégias nas escolas para o controle da obesidade e sedentarismo desde a infância, a fim de se evitar casos precoces de hipertensão e doenças cardiovasculares (AU).

Arterial hypertension (AH) is a disease that affects children and adolescents and its identification, helps to prevent the premature development of cardiovascular diseases. The objective of this study was to verify the presence of blood pressure (BP) above normal and to relate it to obesity and lifestyle of scholars in the cities of Bauru, Ibitinga, Jaú and São Sebastião. A total of 369 children and adolescents were evaluated. Information on health and physical exercise were obtained through anamnesis. After 5 minutes of rest, hemodynamic and anthropometric assessments were performed on each participant. Odds rate was used to assess the risk of above-normal blood pressure in overweight and inactive children. Pearson's correlation was used to correlate anthropometric and hemodynamic variables. Among those evaluated, 28% had altered BP values and 29% were already overweight and obese. In addition, 89% of students were classified as insufficiently active. Among overweight scholars, 48% had altered BP and, among obese, BP was altered in 65%. Overweight children and adolescents had 3.59 times more risk to have altered BP. It can be concluded that the results are extremely relevant to reinforce the inclusion of different strategies in schools for the control of obesity and sedentary lifestyle, in order to avoid early cases of hypertension and cardiovascular diseases (AU).

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Introduction: Primary stability is one of the goals of modern implant dentistry and if achieved, reduces treatment time for prosthetic rehabilitation and the number of interventions made in patients mouth. Several companies state as protocol for connical conection implants, a subcrestally positioning. Objective: This in vitro study aimed to evaluate the effect of placing a conical connection implant equicrestally and subcrestally on static and loading condition in two types of bone density. Material and method: A total of 200 bone cylinders were extracted from femur of pigs, standardized by means of x-rays and computerized microtomography scan (microCT) and separated in low and high density specimens. The implants were placed on the center of the bone cylinders and were evaluated before and after loading by means of microCT and histomorphometry. Result: The results showed that placing the evaluated implant subcrestally provided better primary stability and performance on static and loading situations on low and high density bone. Conclusion: Placing implant subcrestally improve primary stability outcomes under loading and static situations.

Introdução: A estabilidade primária é um dos objetivos da implantodontia moderna e, caso atingida, reduz o tempo de tratamento para a reabilitação protéticas e o número de intervenções realizadas. Diversas empresas preconizam a posição subcrestal no uso de implantes com conexão cônica interna. Objetivo: Este estudo in vitro avaliou o efeito do posicionamento de implantes de conexão conica interna sub e equicrestal sob condições estáticas e em função, considerando dois tipos de densidades ósseas. Material e método: um total de 200 espécimes de osso extraído do femur de suínos e padronizados por meio de radiografias e microtomografias computadorizadas foram separados em densidade alta e baixa. Implantes foram instalados no centro dos especimes e for a avaliados por meio de microCT e histomorfometria. Resultado: Os resultados demonstraram que a colocação de implante subcrestalmente promoveu melhor estabilidade primária e performance em todas as situações, irrespectivamente à densidade óssea. Conclusão: A colocação de implantes subcrestalmente melhora a estabilidade primária em todas as situações, sendo indicada quando da utilização de conexões cônicas internas.

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ABSTRACT Objectives: to report the experience on the operationalization of a university extension project with and for training affirmative action students. Methods: an experience report with a descriptive approach on the operationalization of a university extension project for training affirmative action students, between 2020 and 2021, based on blended-learning and Activity Theory. Results: we carried out 103 activities, including actions for product development, media maintenance and targeted study of themes. They involved 13 students from two institutions, two leaders from ethnic groups and eight instructors. Final Considerations: collaborative relationships provided the exchange of knowledge about public health policies, educational technologies and social media, reducing deficits in the use of technological resources and application in health education. The activities promoted students' leading role coming from affirmative action, in a representative way, from their experiences and needs, being potential for equitable training.

RESUMEN Objetivos: relatar la experiencia sobre la operacionalización de un proyecto de extensión universitaria con y para la formación de estudiantes de acción afirmativa. Métodos: relato de experiencia con enfoque descriptivo sobre la operacionalización de un proyecto de extensión universitaria para formar estudiantes de acción afirmativa, entre 2020 y 2021, basado en la estrategia de aprendizaje semipresencial y Teoría de la Actividad. Resultados: se realizaron 103 actividades, entre acciones de desarrollo de productos, mantenimiento de medios y estudio focalizado de temas. En ellos participaron 13 estudiantes de dos instituciones, dos líderes de etnias y ocho instructores. Consideraciones Finales: las relaciones colaborativas facilitaron el intercambio de conocimientos sobre políticas públicas de salud, tecnologías educativas y redes sociales, reducir los déficits en el uso de los recursos tecnológicos y su aplicación en la educación para la salud. Las actividades promovieron el protagonismo de los estudiantes provenientes de la acción afirmativa, de forma representativa, a partir de sus experiencias y necesidades, siendo potencial para una formación equitativa.

RESUMO Objetivos: relatar a experiência sobre operacionalização de projeto de extensão universitária com e para formação de estudantes de ações afirmativas. Métodos: relato de experiência com abordagem descritiva sobre operacionalização de projeto de extensão universitária para formação de estudantes de ações afirmativas, entre 2020 e 2021, com base na estratégia de aprendizagem blended-learning e na Teoria da Atividade. Resultados: foram realizadas 103 atividades, incluindo ações para desenvolvimento de produtos, manutenções de mídias e estudo direcionado de temas. Envolveram 13 estudantes de duas instituições, duas lideranças de grupos étnicos e oito instrutores. Considerações Finais: as relações colaborativas proporcionaram trocas de saberes sobre políticas públicas de saúde, tecnologias educativas e mídias sociais, diminuindo os déficits sobre uso de recursos tecnológicos e aplicação na educação em saúde. As atividades promoveram o protagonismo de estudantes oriundos de ação afirmativa, de modo representativo, a partir de suas vivências e necessidades, sendo potencial para formação equânime.

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Resumo Este estudo apresenta a análise da literatura científica quanto à aplicação de modelos de apoio à decisão multicritério na priorização de projetos de recursos hídricos, por meio de uma revisão sistemática. Metodologicamente, a pesquisa caracteriza-se como diagnóstico-descritiva. Para a realização da revisão sistemática, seguiu-se o protocolo Preferred Reporting Items for Systematic Reviews and Meta-Analyses. No que tange à análise dos dados, após o levantamento do portfólio bibliográfico, realizou-se uma bibliometria com o auxílio dos softwares VOSviewer e UCINET 6 em conjunto com o NetDraw, e posteriormente se procedeu à metassíntese. Como principais resultados, percebeu-se: (i) uma carência na produção científica sobre o tema investigado (23 artigos); (ii) a recorrente aplicação de métodos de apoio à decisão multicritério na priorização de projetos de recursos hídricos; (iii) o destaque para o governo e companhias de saneamento com setores de maior interesse em projetos de recursos hídricos; (iv) a falta de informação sobre os atores envolvidos na priorização dos projetos e as técnicas que apoiam o consenso da decisão; e (v) além da preocupação econômica, a importância que vem sendo dada às dimensões social e ambiental. A contribuição prática deste estudo é dada pelo conhecimento gerado para as companhias e instituições que desejem realizar a priorização de projetos de recursos hídricos, uma vez que são exibidas metodologias, técnicas, dimensões e critérios que vêm sendo considerados cientificamente na priorização de projetos no setor de recursos hídricos. Já a contribuição teórica é realizada por meio da apresentação de um panorama atual do tema objeto de estudo, de forma a permitir a identificação de lacunas e apontando áreas em desenvolvimento para pesquisas futuras.

Abstract This study presents the analysis of the scientific literature on the application of multicriteria decision aid models in the prioritization of water resources projects through a systematic review. Methodologically, the research is characterized as descriptive diagnosis. For the systematic review, the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol was followed. Regarding data analysis, after surveying a bibliographic portfolio, a bibliometry was carried out with the aid of VOSviewer and UCINET 6 software, in addition to NetDraw software; subsequently, a metasynthesis was performed. As main results, the following aspects were observed: (i) lack of scientific production on the investigated topic (23 articles); (ii) recurring application of multicriteria decision aid methods in prioritizing water resource projects; (iii) emphasis on the government and sanitation companies with sectors of greatest interest in water resources projects; (iv) lack of information about the actors involved in the prioritization of projects and the techniques that support the decision consensus; and (v) in addition to the economic concern, the importance that has been given to social and environmental dimensions. The practical contribution of this study consists in the knowledge generated for companies and institutions that intend to prioritize water resource projects, as this study presents the methodologies, techniques, dimensions, and criteria that have been scientifically considered in the prioritization of projects in the water resources sector. The theoretical contribution consists in the presentation of a current overview of the topic under study, in such a way to allow the identification of gaps and indicating areas under development for future research.

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In this work, an iron ore tailings sample (IOT), collected from a tailings dam in Minas Gerais, Brazil, was characterized. The IOT presented point of zero charge of ∼ 6, specific surface area of 4 m2 g-1, and was mainly composed of hematite and quartz. Subsequently, experiments were performed to evaluate the adsorption of an anionic dye, Direct Red 80 (DR80), and a cationic dye, Methylene Blue (MB), by the IOT, studying the effects of its dose (doseIOT) and the solution initial pH (pH0). The DR80 removal increased with the decrease of the pH0 while the opposite effect occurred in the experiments with the MB, suggesting the process is governed by the adsorption resulting from electrostatic forces. The increase in the doseIOT increased the DR80 and MB removal, which can be attributed to the greater availability of adsorption sites. Pseudo-second order kinetic (R2 > 0.9994) and the Langmuir equilibrium isotherm (R2 > 0.9842) models described well the DR80 adsorption by the IOT, being the reaction rate and maximum adsorption capacity higher at lower pH0. In a regeneration experiment, it was possible to desorb almost entirely the DR80 using a NaOH solution. Additionally, the regenerated IOT was able to adsorb the DR80, demonstrating its reusability. In a preliminary assay, the IOT decreased the colour of the textile wastewater sample at pH0 3. Therefore, the results indicate the potential use of IOT for removing electric-charged pollutants by adsorption, especially anionic ones under acidic conditions.

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Farnesol (FAR) is a sesquiterpene alcohol with a range of reported biological effects including cardioprotective, antioxidant and antiarrhythmic properties. However, due to its volatility, the use of drug incorporation systems, such as cyclodextrins, have been proposed to improve its pharmacological properties. Thus, the aim of this study was to evaluate and characterize the cardiovascular effects of FAR alone, and to investigate the antihypertensive effects of FAR complexed with ß-cyclodextrin (ßCD) in rats. Mean arterial pressure (MAP) and heart rate (HR) were measured before and after intravenous administration of FAR (0,5; 2,5; 5 and 7,5 mg/kg) in normotensive rats, and after oral acute administration (200 mg/kg) of FAR and FAR/ßCD complex in NG-nitro-L-arginine-methyl-ester (L-NAME) hypertensive rats. In normotensive animals, FAR induced dose-dependent hypotension associated with bradycardia. These effects were not affected by pre-treatment with L-NAME or indomethacin (INDO), but were partially attenuated by atropine. Pre-treatment with hexamethonium (HEXA) only affected hypotension. In the hypertensive rats, FAR/ßCD potentialized the antihypertensive effect when compared to FAR alone. Molecular docking experiments demonstrated for the first time that FAR has affinity to bind to the M3 and M2 muscarinic, and nicotinic receptors through hydrogen bonds in the same residues as known ligands. In conclusion, our results demonstrated that FAR induced hypotension associated with bradycardia, possibly through the muscarinic and nicotinic receptors. The inclusion complex with ßCD improved the antihypertensive effects of FAR, which can be relevant to improve current cardiovascular therapy using volatile natural components.

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Doxorubicin (DOX) is an anticancer chemotherapy drug that is widely used in clinical practice. It is well documented that DOX impairs baroreflex responsiveness and left ventricular function and enhances sympathetic activity, cardiac sympathetic afferent reflexes and oxidative stress, which contribute to hemodynamic deterioration. Because resistance training (RT)-induced cardioprotection has been observed in other animal models, the objective of this study was to assess the effects of RT during DOX treatment on hemodynamics, arterial baroreflex, cardiac autonomic tone, left ventricular function and oxidative stress in rats with DOX-induced cardiotoxicity. Male Wistar rats were submitted to a RT protocol (3 sets of 10 repetitions, 40% of one-repetition maximum (1RM) of intensity, 3 times per week, for 8 weeks). The rats were separated into 3 groups: sedentary control, DOX sedentary (2.5 mg/kg of DOX intraperitoneal injection, once a week, for 6 weeks) and DOX + RT. After training or time control, the animals were anesthetized and 2 catheters were implanted for hemodynamic, arterial baroreflex and cardiac autonomic tone. Another group of animals was used to evaluate left ventricular function. We found that RT in DOX-treated rats decreased diastolic arterial pressure, heart rate, sympathetic tone and oxidative stress. In addition, RT increased arterial baroreflex sensitivity, vagal tone and left ventricular developed pressure in rats with DOX-induced cardiotoxicity. In summary, RT is a useful non-pharmacological strategy to attenuate DOX-induced cardiotoxicity.

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