Assuntos
Eritropoetina/biossíntese , Infecções por Uncinaria , Hidroxiureia/uso terapêutico , Metotrexato/uso terapêutico , Policitemia/congênito , Sangria , Feminino , Humanos , Hidroxiureia/administração & dosagem , Hidroxiureia/efeitos adversos , Lactente , Metotrexato/administração & dosagem , Metotrexato/efeitos adversos , Policitemia/tratamento farmacológico , Policitemia/terapiaAssuntos
Anemia Falciforme/complicações , Anidrases Carbônicas/sangue , Transtornos do Crescimento/enzimologia , Zinco/deficiência , Adolescente , Adulto , Anemia Falciforme/sangue , Criança , Desenvolvimento Infantil , Pré-Escolar , Feminino , Transtornos do Crescimento/etiologia , Humanos , Lactente , Masculino , Pessoa de Meia-IdadeRESUMO
Fourteen patients with sickle cell anemia, ages 6 to 20 years, were studied while ingesting high- and low-sodium diets. Although none of the patients had excessive urinary loss of sodium, the majority had elevated plasma renin activities and aldosterone secretion rates. The PRA was higher in patients over 10 years of age; ASR in patients receiving the high-sodium diet increased with age. Patients with sickle cell anemia appeared to compensate for urinary sodium loss between crises. The mechanism of this loss could be a defect in the function of either the distal tubule or the loop of Henle.
Assuntos
Anemia Falciforme/sangue , Hiperaldosteronismo/sangue , Renina/sangue , Adolescente , Adulto , Fatores Etários , Aldosterona/sangue , Criança , Dieta , Dieta Hipossódica , Eletrólitos/sangue , Humanos , Masculino , Sódio/metabolismoRESUMO
A study of four children, two with acute lymphocytic leukemia and two with non-Hodgkin lymphoma, treated for three days with L-asparaginase, suggests that insulin receptors may be involved in the hyperglycemia associated with the use of L-asparaginase. Comparison of insulin receptors of circulating monocytes revealed a marked decrease in their number after treatment. This might also explain the lack of response to insulin treatment in one of the patients with symptomatic hyperglycemia.