RESUMO

The acute treatment of rats and mice with a hydroalcoholic extract from the seeds of Dioclea grandiflora (EHDg) at doses of 250 and 500 mg/kg, by intraperitoneal or oral administration, produced a significant antinociceptive effect in the tail flick and hot plate tests, an effect which was inhibited by naloxone. EHDg given to mice daily for 30 days at a dose of 500 mg/kg, did not cause any observable toxic effect nor any alteration in the pattern of antinociceptive response by the tail immersion test during the course of this treatment. These results suggest that EHDg has a central antinociceptive action devoid of tolerance effect typical of opioid drugs.

Assuntos

Analgésicos não Narcóticos/farmacologia , Fabaceae , Nociceptores/efeitos dos fármacos , Fitoterapia , Extratos Vegetais/uso terapêutico , Sementes/química , Analgésicos não Narcóticos/antagonistas & inibidores , Animais , Brasil , Etanol , Feminino , Masculino , Camundongos , Modelos Animais , Morfina/antagonistas & inibidores , Morfina/farmacologia , Naloxona/farmacologia , Dor/tratamento farmacológico , Extratos Vegetais/farmacologia , Ratos , Ratos Wistar , Tempo de Reação/efeitos dos fármacos