Central antinociceptive effect of a hydroalcoholic extract of Dioclea grandiflora seeds in rodents.
J Ethnopharmacol
; 88(1): 1-4, 2003 Sep.
Article
em En
| MEDLINE
| ID: mdl-12902044
The acute treatment of rats and mice with a hydroalcoholic extract from the seeds of Dioclea grandiflora (EHDg) at doses of 250 and 500 mg/kg, by intraperitoneal or oral administration, produced a significant antinociceptive effect in the tail flick and hot plate tests, an effect which was inhibited by naloxone. EHDg given to mice daily for 30 days at a dose of 500 mg/kg, did not cause any observable toxic effect nor any alteration in the pattern of antinociceptive response by the tail immersion test during the course of this treatment. These results suggest that EHDg has a central antinociceptive action devoid of tolerance effect typical of opioid drugs.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sementes
/
Nociceptores
/
Extratos Vegetais
/
Analgésicos não Narcóticos
/
Fabaceae
/
Fitoterapia
Limite:
Animals
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
J Ethnopharmacol
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Irlanda