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1.
Artigo em Inglês | MEDLINE | ID: mdl-27783925

RESUMO

In this work, we studied the characteristics of recovery from desensitization of the light-elicited current of crayfish. Applying a two-flash protocol, we found that the first flash triggers a current that activates with a noticeable latency, reaches a peak value, and thereafter decays along a single exponential time course. In comparison with the first-elicited current, the current elicited by the second flash not only presents an expected smaller peak current, depending on the time between flashes, but it also displays a different latency and decay time constant. Recovery of the first flash values of these current parameters depends on the circadian time at which the experiments are conducted, and on the presence of pigment-dispersing hormone. Our data also suggest the existence of distinctive desensitized states, whose induction depends on circadian time and the presence of pigment-dispersing hormone.


Assuntos
Astacoidea/fisiologia , Ritmo Circadiano , Hormônios de Invertebrado/metabolismo , Células Fotorreceptoras de Invertebrados/fisiologia , Algoritmos , Animais , Aquicultura , Astacoidea/crescimento & desenvolvimento , Fenômenos Eletrofisiológicos , Olho , Técnicas In Vitro/veterinária , Cinética , Muda , Tempo de Reação
2.
Math Biosci Eng ; 11(2): 317-30, 2014 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-24245720

RESUMO

Mathematical models have been very useful in biological research. From the interaction of biology and mathematics, new problems have emerged that have generated advances in the theory, suggested further experimental work and motivated plausible conjectures. From our perspective, it is absolutely necessary to incorporate modeling tools in the study of circadian rhythms and that without a solid mathematical framework a real understanding of them will not be possible. Our interest is to study the main process underlying the synchronization in the pacemaker of a circadian system: these mechanisms should be conserved in all living beings. Indeed, from an evolutionary perspective, it seems reasonable to assume that either they have a common origin or that they emerge from similar selection circumstances. We propose a general framework to understand the emergence of synchronization as a robust characteristic of some cooperative systems of non-linear coupled oscillators. In a first approximation to the problem we vary the topology of the network and the strength of the interactions among oscillators. In order to study the emergent dynamics, we carried out some numerical computations. The results are consistent with experiments reported in the literature. Finally, we proposed a theoretical framework to study the phenomenon of synchronization in the context of circadian rhythms: the dissipative synchronization of nonautonomous dynamical systems.


Assuntos
Relógios Biológicos/fisiologia , Ritmo Circadiano/fisiologia , Modelos Biológicos , Simulação por Computador , Humanos
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