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Modeling some properties of circadian rhythms.
Lara-Aparicio, Miguel; Barriga-Montoya, Carolina; Padilla-Longoria, Pablo; Fuentes-Pardo, Beatriz.
Afiliação
  • Lara-Aparicio M; Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico,, Mexico. laraapariciomiguel@gmail.com.
Math Biosci Eng ; 11(2): 317-30, 2014 Apr.
Article em En | MEDLINE | ID: mdl-24245720
Mathematical models have been very useful in biological research. From the interaction of biology and mathematics, new problems have emerged that have generated advances in the theory, suggested further experimental work and motivated plausible conjectures. From our perspective, it is absolutely necessary to incorporate modeling tools in the study of circadian rhythms and that without a solid mathematical framework a real understanding of them will not be possible. Our interest is to study the main process underlying the synchronization in the pacemaker of a circadian system: these mechanisms should be conserved in all living beings. Indeed, from an evolutionary perspective, it seems reasonable to assume that either they have a common origin or that they emerge from similar selection circumstances. We propose a general framework to understand the emergence of synchronization as a robust characteristic of some cooperative systems of non-linear coupled oscillators. In a first approximation to the problem we vary the topology of the network and the strength of the interactions among oscillators. In order to study the emergent dynamics, we carried out some numerical computations. The results are consistent with experiments reported in the literature. Finally, we proposed a theoretical framework to study the phenomenon of synchronization in the context of circadian rhythms: the dissipative synchronization of nonautonomous dynamical systems.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relógios Biológicos / Ritmo Circadiano / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Math Biosci Eng Ano de publicação: 2014 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Relógios Biológicos / Ritmo Circadiano / Modelos Biológicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Revista: Math Biosci Eng Ano de publicação: 2014 Tipo de documento: Article País de afiliação: México País de publicação: Estados Unidos