RESUMO
OBJECTIVE: To explore whether the IFNL3/4 rs12979860 genotype may influence serum levels or production of interferon-inducible protein-10 (IP-10) by peripheral blood mononuclear cells from patients with systemic lupus erythematosus (SLE). METHODS: Sixty-six patients with SLE and 22 healthy blood donors (controls) were included. The IFNL3/4 rs12979860 polymorphism was genotyped by real-time polymerase chain reaction. IP-10 levels in sera supernatants of IFNα stimulated peripheral blood mononuclear cells were measured by enzime-linked immunosorbent assay. RESULTS: Allelic frequencies were CC (29%), CT (52%) and TT (20%) in SLE, and CC (32%), CT (41%) and TT (27%) in healthy controls. Median serum IP-10 levels were higher in SLE patients than in controls (190.8 versus 118.1 pg/ml; p < 0.001), particularly in those with high disease activity (278.5 versus 177.2 pg/ml; p = 0.037). However, serum IP-10 levels were not influenced by IFNL3/4 genotypes. Higher IP-10 production by peripheral blood mononuclear cells was found in both SLE patients (median 519.3 versus 207.6 pg/ml; p = 0.012) and controls (median 454.0 versus 201.7 pg/ml; p = 0.034) carrying the IFNL3/4 C allele compared with carriers of the T allele. CONCLUSIONS: Although IFNL3/4 rs12979860 allele C does not appear to influence serum IP-10 levels in SLE, it plays an important role in the production of IP-10 by peripheral blood mononuclear cells after IFNα stimulation.
Assuntos
Quimiocina CXCL10/sangue , Interferons/genética , Interleucinas/genética , Leucócitos Mononucleares/metabolismo , Lúpus Eritematoso Sistêmico/genética , Adulto , Alelos , Estudos de Casos e Controles , Feminino , Frequência do Gene , Predisposição Genética para Doença , Humanos , Lúpus Eritematoso Sistêmico/sangue , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo ÚnicoRESUMO
El trabajo evalua la biodegradación de polietineo de alta y de baja densidad de bolsas enterradas en: humus de lonbriz, compost de cama de aves, residuos de comida y barrido
RESUMO
Trabajo presentado en forma de afiche al 10o. Congreso Argentino de Saneamiento y Medio Ambiente, que mereció el premio AIDIS Argentina instituido para el mejor trabajo de esa categoría
Assuntos
Argentina , Líquido Percolado , Aterros Sanitários , Biodegradação AmbientalRESUMO
Trabajo presentado en forma de afiche al 10o. Congreso Argentino de Saneamiento y Medio Ambiente, que mereció el premio AIDIS Argentina instituido para el mejor trabajo de esa categoría
Assuntos
Argentina , Aterros Sanitários , Biodegradação Ambiental , Líquido PercoladoRESUMO
Tomando en cuenta que las características de los líquidos de lixiviado que se acumulan en los sitios de disposición final dependen de numerosas variables, este trabajo se ha realizado con ensayos de biodegradabilidad de lixiviados de un relleno sanitario de la Pcia. de Jujuy, como uno de los pasos previos al diseño del sistema de descontaminación más apropiado para estos desechos
Assuntos
Aterros Sanitários , Líquido Percolado , CongressoRESUMO
Se muestra la posibilidad de tratar anaerobicamente liquidos residuales ácidos sin adicionar alcalis, y sin recurrir ni a la recirculación del líquido tratado ni a un reactor bifásico
Assuntos
Purificação da Água , Tratamento AnaeróbioRESUMO
We evaluated the in vitro disintegration time and the remanent digestive activity of eight pancreatic supplements under pH conditions similar to the gastrointestinal tract. They were incubated for 45 min at various pH levels (1, 3 or 6) and continued thereafter at pH 6, for another 135 min. The activities of lipase and trypsin were evaluated titrimetrically every 15 min. At pH 6, the products without an enteric coat and Creon, showed the shortest disintegration times; under acidic conditions, those times were longer in all the enteric coated products. At constant pH 6, lipase activity was greater in Creon, Pankreon and Cotazym-B; trypsin activity was greater in Nutrizym-C, Onoton and Cotazym-B. After acidic pH exposure enzyme bioavailability was decreased in all the products. Disintegration times and acid inactivation of enzymes, should be considered when prescribing PS.