[The in-vitro digestive availability of lipase and trypsin in pancreatic supplements under different degrees of acidity]. / Disponibilidad digestiva in vitro de lipasa y tripsina en suplementos pancreáticos bajo diferentes grados de acidez.
Rev Gastroenterol Mex
; 58(1): 21-4, 1993.
Article
em Es
| MEDLINE
| ID: mdl-8362147
We evaluated the in vitro disintegration time and the remanent digestive activity of eight pancreatic supplements under pH conditions similar to the gastrointestinal tract. They were incubated for 45 min at various pH levels (1, 3 or 6) and continued thereafter at pH 6, for another 135 min. The activities of lipase and trypsin were evaluated titrimetrically every 15 min. At pH 6, the products without an enteric coat and Creon, showed the shortest disintegration times; under acidic conditions, those times were longer in all the enteric coated products. At constant pH 6, lipase activity was greater in Creon, Pankreon and Cotazym-B; trypsin activity was greater in Nutrizym-C, Onoton and Cotazym-B. After acidic pH exposure enzyme bioavailability was decreased in all the products. Disintegration times and acid inactivation of enzymes, should be considered when prescribing PS.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Pancreáticos
/
Tripsina
/
Digestão
/
Lipase
Limite:
Humans
Idioma:
Es
Revista:
Rev Gastroenterol Mex
Ano de publicação:
1993
Tipo de documento:
Article
País de publicação:
México