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1.
Int. braz. j. urol ; 39(6): 867-874, Nov-Dec/2013. tab, graf
Artigo em Inglês | LILACS | ID: lil-699120

RESUMO

Purpose To assess the prevalence of LUTS, urinary tract and urodynamics changes in patients with Friedreich's Ataxia (FA), the most common form of hereditary ataxia. Materials and Methods This study evaluated 258 patients with genetically confirmed diagnoses of FA. Of the patients, 158 responded to a questionnaire which assessed their urinary symptoms. Patients with clinical changes underwent renal function examinations, ultrasound, and urodynamic studies (UDS). Results The sample analyzed showed that 82% of the patients complained of LUTS, although only 22% related the symptoms with quality of life impairment. Twenty eight (18%) of them agreed to undergo urodynamic evaluation. Urgency was the most common symptom. The exam was normal in 4 (14%) and detrusor underactivity was the most common finding. 14% (4 patients) presented with dilatation of the upper urinary tract at ultrasound scans. None of them had creatinine alterations. Conclusions LUTS was found in a large percentage of patients with FA, but only a few related it to their quality of life impairment. Although creatinine levels was normal in this sample, some patients may show upper urinary tract abnormalities, with deserves close observation and proper care. .


Assuntos
Adulto , Feminino , Humanos , Masculino , Adulto Jovem , Ataxia de Friedreich/fisiopatologia , Sintomas do Trato Urinário Inferior/fisiopatologia , Bexiga Urinária/fisiopatologia , Urodinâmica/fisiologia , Brasil/epidemiologia , Sintomas do Trato Urinário Inferior/epidemiologia , Prevalência , Fatores Sexuais , Inquéritos e Questionários , Fatores de Tempo , Transtornos Urinários/fisiopatologia
2.
Int Braz J Urol ; 39(6): 867-74, 2013.
Artigo em Inglês | MEDLINE | ID: mdl-24456779

RESUMO

PURPOSE: To assess the prevalence of LUTS, urinary tract and urodynamics changes in patients with Friedreich's Ataxia (FA), the most common form of hereditary ataxia. MATERIALS AND METHODS: This study evaluated 258 patients with genetically confirmed diagnoses of FA. Of the patients, 158 responded to a questionnaire which assessed their urinary symptoms. Patients with clinical changes underwent renal function examinations, ultrasound, and urodynamic studies (UDS). RESULTS: The sample analyzed showed that 82% of the patients complained of LUTS, although only 22% related the symptoms with quality of life impairment. Twenty eight (18%) of them agreed to undergo urodynamic evaluation. Urgency was the most common symptom. The exam was normal in 4 (14%) and detrusor underactivity was the most common finding. 14% (4 patients) presented with dilatation of the upper urinary tract at ultrasound scans. None of them had creatinine alterations. CONCLUSIONS: LUTS was found in a large percentage of patients with FA, but only a few related it to their quality of life impairment. Although creatinine levels was normal in this sample, some patients may show upper urinary tract abnormalities, with deserves close observation and proper care.


Assuntos
Ataxia de Friedreich/fisiopatologia , Sintomas do Trato Urinário Inferior/fisiopatologia , Bexiga Urinária/fisiopatologia , Urodinâmica/fisiologia , Adulto , Brasil/epidemiologia , Feminino , Humanos , Sintomas do Trato Urinário Inferior/epidemiologia , Masculino , Prevalência , Fatores Sexuais , Inquéritos e Questionários , Fatores de Tempo , Transtornos Urinários/fisiopatologia , Adulto Jovem
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