RESUMO
BACKGROUND: US-born Latinos have a higher incidence of hepatocellular carcinoma (HCC) than foreign-born Latinos. Acculturation to unhealthy lifestyle behaviors and an immigrant self-selection effect may play a role. In this study, the authors examined the influence of generational status on HCC risk among Mexican American adults. METHODS: The analytic cohort included 31,377 self-reported Mexican Americans from the Multiethnic Cohort Study (MEC). Generational status was categorized as: first-generation (Mexico-born; n = 13,382), second-generation (US-born with one or two parents born in Mexico; n = 13,081), or third-generation (US-born with both parents born in the United States; n = 4914). Multivariable Cox proportional hazards regression was performed to examine the association between generational status and HCC incidence. RESULTS: In total, 213 incident HCC cases were identified during an average follow-up of 19.5 years. After adjusting for lifestyle and neighborhood-level risk factors, second-generation and third-generation Mexican Americans had a 37% (hazard ratio [HR], 1.37; 95% confidence interval [CI], 0.98-1.92) and 66% (HR, 1.66; 95% CI, 1.11-2.49) increased risk of HCC, respectively, compared with first-generation Mexican Americans (p for trend = 0.012). The increased risk associated with generational status was mainly observed in males (second-generation vs. first-generation: HR, 1.60 [95% CI, 1.05-2.44]; third-generation vs. first-generation: HR, 2.08 [95% CI, 1.29-3.37]). CONCLUSIONS: Increasing generational status of Mexican Americans is associated with a higher risk of HCC. Further studies are needed to identify factors that contribute to this increased risk.
Assuntos
Carcinoma Hepatocelular , Neoplasias Hepáticas , Adulto , Humanos , Masculino , Aculturação , Carcinoma Hepatocelular/epidemiologia , Estudos de Coortes , Neoplasias Hepáticas/epidemiologia , Americanos Mexicanos , México , Fatores de Risco , Estados Unidos/epidemiologia , Características da Família/etnologiaRESUMO
This study aims to test the association between geriatric depression and the quality of life of older adults in long-term care facilities in Brazil. Results showed that there was a significant correlation among four of the six domains that were measured in the WHOQOL-OLD questionnaire of those demonstrating symptoms and those without. In conclusion, higher depression scores were reported by participants who had lower quality of life scores. Mental health care should be carefully addressed among institutionalized older adults in long-term facilities.
Lo objectivo es probar la asociación entre la depresión geriátrica y la calidad de vida de los adultos mayores en centros de cuidados a largo plazo en Brasil. Los resultados mostraron que hubo una correlación significativa entre cuatro de los seis domínios que se midieron em el cuestionario WHOQOL-OLD de aquellos que muestram sintomas y los que no. En conclusión, los participantes que tenían puntuaciones de calidad de vida más bajas informaron puntuaciones de depresión más altas. La atención de la salud mental debe abordarse cuidadosamente entre los adultos mayores institucionalizados en instalaciones a largo plazo.
Este estudo tem como objetivo testar a associação entre depressão geriátrica e qualidade de vida de idosos em instituições de longa permanência no Brasil. Os resultados mostraram que houve uma correlação significativa entre quatro dos seis domínios que foram medidos no questionário WHOQOL-OLD daqueles que demonstraram sintomas e aqueles sem. Em conclusão, escores mais altos de depressão foram relatados pelos participantes que apresentaram escores mais baixos de qualidade de vida. Os cuidados de saúde mental devem ser cuidadosamente tratados entre idosos institucionalizados em instalações de longo prazo.