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Increasing risk of hepatocellular carcinoma with successive generations in the United States among Mexican American adults: The Multiethnic Cohort.
Acuna, Nicholas; Zhou, Kali; Pinheiro, Paulo S; Cheng, Iona; Shariff-Marco, Salma; Lim, Tiffany; Wilkens, Lynne R; Le Marchand, Loïc; Haiman, Christopher A; Setiawan, Veronica Wendy.
Afiliação
  • Acuna N; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Zhou K; Division of Gastrointestinal and Liver Diseases, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Pinheiro PS; Research Center for Liver Disease, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Cheng I; Sylvester Comprehensive Cancer Center, Miami, Florida, USA.
  • Shariff-Marco S; Department of Public Health Sciences, University of Miami School of Medicine, Miami, Florida, USA.
  • Lim T; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
  • Wilkens LR; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
  • Le Marchand L; Department of Epidemiology and Biostatistics, University of California, San Francisco, California, USA.
  • Haiman CA; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
  • Setiawan VW; Center for Genetic Epidemiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Cancer ; 130(2): 267-275, 2024 01.
Article em En | MEDLINE | ID: mdl-37982329
BACKGROUND: US-born Latinos have a higher incidence of hepatocellular carcinoma (HCC) than foreign-born Latinos. Acculturation to unhealthy lifestyle behaviors and an immigrant self-selection effect may play a role. In this study, the authors examined the influence of generational status on HCC risk among Mexican American adults. METHODS: The analytic cohort included 31,377 self-reported Mexican Americans from the Multiethnic Cohort Study (MEC). Generational status was categorized as: first-generation (Mexico-born; n = 13,382), second-generation (US-born with one or two parents born in Mexico; n = 13,081), or third-generation (US-born with both parents born in the United States; n = 4914). Multivariable Cox proportional hazards regression was performed to examine the association between generational status and HCC incidence. RESULTS: In total, 213 incident HCC cases were identified during an average follow-up of 19.5 years. After adjusting for lifestyle and neighborhood-level risk factors, second-generation and third-generation Mexican Americans had a 37% (hazard ratio [HR], 1.37; 95% confidence interval [CI], 0.98-1.92) and 66% (HR, 1.66; 95% CI, 1.11-2.49) increased risk of HCC, respectively, compared with first-generation Mexican Americans (p for trend = 0.012). The increased risk associated with generational status was mainly observed in males (second-generation vs. first-generation: HR, 1.60 [95% CI, 1.05-2.44]; third-generation vs. first-generation: HR, 2.08 [95% CI, 1.29-3.37]). CONCLUSIONS: Increasing generational status of Mexican Americans is associated with a higher risk of HCC. Further studies are needed to identify factors that contribute to this increased risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Adult / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carcinoma Hepatocelular / Neoplasias Hepáticas Limite: Adult / Humans / Male País/Região como assunto: Mexico Idioma: En Revista: Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos