RESUMEN

Tangeretin and nobiletin are polymethoxylated flavonoids in citrus peel. Both tangeretin and nobiletin are bitter; however, their bitterness has not been evaluated using human bitter taste receptors (hTAS2Rs). We screened 25 kinds of hTAS2Rs and found that hTAS2R14 and hTAS2R46 received both compounds.

Asunto(s)

Flavonas/química , Flavonas/farmacología , Receptores Acoplados a Proteínas G/metabolismo , Células HEK293 , Humanos