RESUMEN
The COVID-19 pandemic created global disruption in health professions education and healthcare practice, necessitating an abrupt move to digital delivery. A longitudinal survey was conducted to track the evolution of global responses to the pandemic. During the initial stages, educational and health institutions were forced to adapt quickly without careful consideration of optimal pedagogy, practices, and effectiveness of implemented approaches. In this paper, we report the results of Phase 3 of the global survey that was distributed between November 2021 and February 2022 through InterprofessionalResearch.Global (IPR.Global). The Phase 3 qualitative survey received 27 responses, representing 25 institutions from 13 countries in 6 regions. Using inductive thematic analysis, the data analysis resulted in three emerging themes: Impact of the pandemic on the delivery of interprofessional education and collaborative practice (IPECP); Impact of the pandemic on the healthcare system (team, population/client health, clients); and Sustainability and innovation. This study highlights the evolving nature of health education and collaborative practices in response to the COVID-19 pandemic. IPECP educators need to be resilient and deal with the complexities of face-to-face and digital learning delivery. Preparing for emerging forms of teamwork is essential for new work contexts and optimal health services.
Asunto(s)
COVID-19 , Conducta Cooperativa , Educación Interprofesional , Relaciones Interprofesionales , SARS-CoV-2 , Humanos , COVID-19/epidemiología , Educación Interprofesional/organización & administración , Pandemias , Salud Global , Estudios Longitudinales , Grupo de Atención al Paciente/organización & administración , Personal de Salud/educaciónRESUMEN
As alternatives of brominated flame retardants, organophosphate flame retardants (OPFRs) can be detected in multiple marine environmental media. Tris(1-chloro-2-propyl)phosphate (TCPP) was one of the most frequently and abundantly detected OPFRs in the Bohai Sea. Exposure to TCPP has been shown to induce abnormal behavior in zebrafish as well as neurotoxicity in Caenorhabditis elegans. However, there is a lack of mechanism investigations on the toxic effects of TCPP at molecular levels. In this work, proteomics and metabolomics were integrated to analyze the proteome and metabolome responses in rockfish Sebastes schlegeli treated with TCPP (10 and 100 nM) for 15 days. A total of 143 proteins and 8 metabolites were significantly altered in rockfish following TCPP treatments. The responsive proteins and metabolites were predominantly involved in neurotransmission, neurodevelopment, signal transduction, cellular transport, cholesterol metabolism, bile acid synthesis, and detoxification. Furthermore, a hypothesized network of proteins, metabolites, and pathways in rockfish was summarized based on the combination of proteomic and metabolomic results, showing some key molecular events in response to TCPP. Overall, the present study unraveled the molecular responses at protein and metabolite levels, which provided a better understanding of toxicological effects and mechanisms of TCPP in marine teleost.
Asunto(s)
Retardadores de Llama , Proteómica , Animales , Metabolómica , Organofosfatos , Compuestos Organofosforados , Perciformes , FosfatosRESUMEN
All living organisms have acquired the outstanding ability to overcome the limitations imposed by changeable environments through the gain of genetic traits over years of evolution and the tendency of individuals to associate in communities. The complementation of a singular weakness, the deployment of reinforcement for the good of the community, the better use of resources, or effective defense against external aggression are advantages gained by this communal behavior. Communication has been the cohesive element prompting the global responses that promote efficiency in two features of any community: specialization in differentiated labor and the spatio-temporal organization of the environment. These principles illustrate that what we call human ecology also applies to the cellular world and is exemplified in eukaryotic organisms, where sophisticated cell-to-cell communication networks coordinate cell differentiation and the specialization of multiple tissues consisting of numerous cells embedded in a multifunctional extracellular matrix. This sophisticated molecular machinery appears, however, to be invented by the "simple" but still fascinating bacteria. What I will try to expand in the following sections are notions of how "single prokaryotic cells" organize a multicellular community. [Int Microbiol 19(2):81-90 (2016)].