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Background: In low- to middle-income countries, malnutrition is a major contributing factor in children failing to achieve their developmental potential. The prevention of malnutrition requires, among others, nutritious, diverse and safe foods in early childhood. Aim: The study aimed to determine primary caregivers' choices and motivation for the foods they fed their children. Setting: The study was conducted among early childhood development centres in the Xhariep District, Free State. Methods: A qualitative study was undertaken. Twelve participants who met the inclusion criteria were conveniently sampled. Semi-structured interviews were conducted to find out the primary caregivers' choices and motivation for foods they fed their children until data saturation was reached. Results: The mean age of the participants was 31 years. Nine of the participants relied on social grants as a source of income. The participants reported feeding their children mainly maize porridge, milk, juice, and water. Vegetables and meat were fed to the children once a week. Fruits were fed to the children at the beginning of the month. Conclusion: The level of education, employment status, and community support influenced the primary caregivers' feeding practices. The content of the diets of their children was insufficient in vegetables and fruit, not only placing the children at risk of undernutrition but also at risk of obesity and micronutrient deficiencies. Primary caregivers ensured their children were fed, although limited foods were offered. Contribution: This research creates awareness of the level of social progress and access to resources within rural communities in the Xhariep district, and gives the opportunity to extend this research to confirm these findings in other poverty-stricken areas.

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Introduction Obesity can develop from childhood through adulthood and is influenced by genetics, family, and environmental factors. Parenting educational style is believed to contribute to an individual's future weight status. This study aims to assess the connection between parenting educational style and weight-related issues. Methods The study involved 487 participants, including either the mother and/or father and their school-age child, aged 6-11, at a primary care unit in Mexico. Fifty-two records were excluded due to incomplete questionnaires, electronic records, and refusal of informed consent. The study group consisted of 435 adults and children who completed an adapted version of the Parenting Styles and Dimensions Questionnaire (PSDQ) tailored for the Mexican population. The researchers also gathered anthropometric measurements of the primary caregiver (parent) and the child from the electronic record to calculate their BMI and nutritional status. We used IBM SPSS Statistics for Windows, Version 25.0 (Released 2017; IBM Corp., Armonk, NY, USA) to analyze the data. The Pearson Chi-square and Fisher's exact test were applied to examine interaction terms between variables, revealing a statistically significant p-value of <0.05. Results Out of the 435 patients examined, there were 229 (52.6%) children and 206 (47.3%) adult patients. Grade 2 obesity was present in 90 (39.3%) school-age children and 104 (50.5%) adult patients. The family's parenting educational style, as determined by the PSDQ questionnaire, was found to be permissive in 143 (69.4%) patients, authoritarian in 33 (16.0%) patients, and authoritative in 30 (14.6%) patients. Conclusions Parenting educational style and the PSDQ tool can be used to assess how parents influence the development of obesogenic home environments. We observed that a permissive parenting educational style was linked to a more obesogenic environment, whereas an authoritative parenting educational style was linked to a less obesogenic environment.

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La lactancia materna exclusiva (LME) ha sido considerada por varios organismos internacionales como la solución para combatir la desnutrición infantil, la cual es considerada como un problema de salud pública. Bajo este contexto, la presente investigación busca encontrar cuáles son los determinantes de la LME en el Ecuador, y mostrar cómo influye el nivel educativo de la madre sobre la duración de la lactancia materna exclusiva. Para cumplir dicho objetivo se emplea un modelo probabilístico obteniendo como resultado que el nivel de instrucción de la madre, la etnia, el quintil de ingresos, el género del recién del bebé y la edad de la madre juegan un papel importante sobre la duración de la lactancia materna en el Ecuador. En el caso del nivel de instrucción se encuentra que las mujeres con una educación superior tienen menos probabilidad de dar LME, por seis meses o más, que las madres sin un nivel de educación

Exclusive breastfeeding (EBF) has been considered by several international organizations as the solution to combat child malnutrition, which is considered a public health problem. In this context, the present research seeks to find the determinants of EBF in Ecuador, and to show how the mother's educational level influences the duration of exclusive breastfeeding. In order to fulfill this objective, a probabilistic model was used, obtaining as a result that the mother's level of education, ethnicity, income quintile, gender of the newborn and the mother's age play an important role in the duration of breastfeeding in Ecuador. In the case of educational level, it is found that women with higher education are less likely to breastfeed for six months or more than mothers with no education.

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La lactancia materna exclusiva (LME) ha sido considerada por varios organismos internacionales como la solución para combatir la desnutrición infantil, la cual es considerada como un problema de salud pública. Bajo este contexto, la presente investigación busca encontrar cuáles son los determinantes de la LME en el Ecuador, y mostrar cómo influye el nivel educativo de la madre sobre la duración de la lactancia materna exclusiva. Para cumplir dicho objetivo se emplea un modelo probabilístico obteniendo como resultado que el nivel de instrucción de la madre, la etnia, el quintil de ingresos, el género del recién del bebé y la edad de la madre juegan un papel importante sobre la duración de la lactancia materna en el Ecuador. En el caso del nivel de instrucción se encuentra que las mujeres con una educación superior tienen menos probabilidad de dar LME, por seis meses o más, que las madres sin un nivel de educación.

Exclusive breastfeeding (EBF) has been considered by several international organizations as the solution to combat child malnutrition, which is considered a public health problem. In this context, the present research seeks to find the determinants of EBF in Ecuador, and to show how the mother's educational level influences the duration of exclusive breastfeeding. In order to fulfill this objective, a probabilistic model was used, obtaining as a result that the mother's level of education, ethnicity, income quintile, gender of the newborn and the mother's age play an important role in the duration of breastfeeding in Ecuador. In the case of educational level, it is found that women with higher education are less likely to breastfeed for six months or more than mothers with no education.

O aleitamento materno exclusivo (AME) tem sido considerado por várias organizações internacionais como a solução para combater a desnutrição infantil, que é considerada um problema de saúde pública. Neste contexto, esta investigação tem como objetivo encontrar os determinantes do AME no Equador, e mostrar como o nível educacional da mãe influencia a duração do aleitamento materno exclusivo. Para cumprir este objetivo, é utilizado um modelo probabilístico, com o resultado de que o nível de educação da mãe, a etnia, o quintil de rendimentos, o sexo do recém-nascido e a idade da mãe desempenham um papel importante na duração do aleitamento materno no Equador. No caso do nível de educação, verifica-se que as mulheres com educação superior têm menos probabilidades de amamentar durante seis meses ou mais do que as mães sem educação.

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Purpose: The globally increasing older population raises concerns about age-related conditions, including cognitive impairment and depressive symptoms. In Latin America, nearly one-third of the population is affected by either of these conditions. However, data investigating the association between cognitive impairment and depressive symptoms, particularly in Brazil, are limited to small-scale studies that have not carefully examined the critical effects of variables such as education level and socioeconomic status on this relationship. We aimed at exploring this association in a representative population-based cohort. Methods: We used the Brazilian Longitudinal Study of Aging (ELSI-BRAZIL) database to examine the relationship between depressive symptoms and cognitive impairment in Brazilian older adults, adjusted for potential confounders. Direct acyclic graphs and multivariable linear regression were used to build our model. Depressive symptoms were measured using a short version of the Center for Epidemiologic Studies Scale (CES D-8), and combined memory recall test as a surrogate of cognitive impairment. Results: The study included 8280 participants. Only education level was identified as a confounder for the relationship between memory loss and depressive symptoms. After adjusting for age, sex, and education level, there was strong evidence for a negative association between depressive symptoms and memory performance. For every 5-unit increase in the CES D-8 score, there was a reduction in memory capacity, translating to a loss of approximately one word in the combined words recall test (mean - 0.18, 95% CI -0.22; -0.15, P < 0.001). In addition, we found strong evidence for an interaction between socioeconomic status and depressive symptoms. Subjects belonging to medium socioeconomic status (SES) showed more pronounced memory decline, when compared to those with lower SES (mean - 0.28, 95% CI -0.42 to -0.14, P < 0.001). Conclusions: In adults aged over 50, after adjusting for sex, age, and educational level, a 5-unit increase in CES D-8 score is associated with loss of one point in the combined memory recall test. This association seems to be confounded by educational level and significantly modified by socioeconomic status.

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BACKGROUND AND STUDY AIMS: Mucosal healing (MH) is a crucial indicator of therapeutic effectiveness and prognosis in Crohn's disease (CD). Rapid achievement and long-term maintenance of MH can alleviate the financial and psychological burden on patients. This study aimed to investigate the factors associated with MH in CD patients and enhance clinicians' understanding. PATIENTS AND METHODS: Patients diagnosed with CD between January 2010 and December 2019 at our hospital were included and divided into two groups based on the attainment of MH during the follow-up period. Demographic data, symptoms, disease classification, laboratory examination results, and treatments were collected and compared between the two groups. Factors with a P-value <0.2 were subjected to multivariate logistic regression analysis to identify the related factors of MH. RESULTS: Multivariate logistic regression analysis of CD patients revealed that educational level [odds ratio (OR) = 8.167, 95 % confidence interval (CI) 1.440-46.303, P = 0.018] and biological therapy (OR = 15.291, 95 % CI 1.404-166.543, P = 0.025) were associated with MH. CONCLUSION: Educational level and biological therapy are factors related to MH in CD patients. These findings suggest that the use of biological therapy and patients' better understanding of the disease contribute to achieving MH.

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BACKGROUND: Nutrition exerts a fundamental role in the prevention of obesity (OB). The aim of this study was to assess the extent to which well recognized risk factors for early OB can be associated to overweight (OW) or OB under a standardized nutritional approach and surveillance in toddlers. METHODS: The eligible population was represented by 676 toddlers aged 24-36 months, assigned to 18 primary care pediatricians trained on nutritional issues who shared a standardized nutritional approach. Six-hundred-twenty-nine children (333 boys), mean age 27.8 ± 4.2 months were effectively included in this observational study. Parents received nutritional advice with particular emphasis to proteins and sugar composition supported by leaflets and reinforced at each visit. Body mass index was assessed at the age of 24-36 months. The following individual and family risk factors were considered: gestational age, birth weight, eutocic/caesarean delivery, milk feeding history, household smoking or antibiotics exposure, parents' weight, height and educational level. Prevalence of OW/OB was compared to a group of 742 toddlers (373 boys) under usual care. RESULTS: Under a standardized nutritional counselling, 28.1% toddlers were classified as OW/OB compared to 36.9% toddlers under usual care (p = 0.005). In unadjusted models, parental OW/OB was significantly associated to OW/OB in toddlers (p < 0.01), while high birth weight did not reach statistical significance (p = 0.07). In adjusted models, including all the explanatory variables studied, only paternal OW/OB vs. normal weight was significantly associated to OW/OB in toddlers (OR 2.035, 95% confidence interval 1.206-3.436). No protective effect of exclusive breast feeding during the first 6 months of age was demonstrated. CONCLUSIONS: Toddlers under a standardized nutrition counselling focused to limit protein and simple sugars, showed lower prevalence of OW/OB compared to usual care. Healthy promotion activities should take into account the influence of paternal BMI on the offspring adiposity.

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Introduction: Evidence on parental educational level (PEL) as a risk factor for Eating Disorders (EDs) is mixed, and no study has assessed its role in relation to the compliance and outcomes of treatments in EDs. Further, no study differentiated from the educational level of mothers and fathers, nor considered the possible mediation of perfectionism in fostering EDs. Methods: A clinical sample of 242 first-ever admitted inpatients with EDs provided information on PEL and completed the following questionnaires: the Eating Disorder Examination Questionnaire (EDE-Q) and the Frost Multidimensional Perfectionism Scale (F-MPS). Clinicians also provided information on the Hamilton Rating Scale for Anxiety (HAM-A) and the Hamilton Rating Scale for Depression (HAM-D) for each participant. Results: Individuals with high PEL (whether mothers, fathers, or both parents) showed significantly higher scores on depressive symptoms and lower on parental criticism, were younger, had an earlier age of onset, had fewer years of illness, more were students and employed, and fewer had offspring. Individuals with fathers or both parents with high educational levels suffered more from Anorexia Nervosa rather than Bulimia Nervosa, had a longer length of stay during the current hospitalization, had less dietary restraint, and had higher personal standards. Individuals with mothers with high educational levels showed a lower rate of previous substance or alcohol addiction. Personal standards partially mediated the relationship between higher PEL and lower dietary restraint. Discussion: PEL emerged to be a twofold psychosocial risk factor, being associated with higher depressive symptoms and a longer length of stay, but also with a shorter duration of illness and better scholar and working involvement. Higher PEL was related to higher personal standards but not to global perfectionism. Patterns of eating psychopathology emerged based on the high PEL of mothers or fathers.

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BACKGROUND: Patients undergoing dialysis have an impaired health-related quality of life (HRQOL). There are conflicting data from small series on whether patient-related factors such as educational level have an impact on experienced HRQOL. The aim of this study was to investigate the association between educational level and HRQOL in dialysis patients. METHODS: In a single-center retrospective cross-sectional study HRQOL was measured using the Kidney Disease Quality of Life Short Form-36 (KDQOL-SF36) in prevalent chronic dialysis patients. Educational level was categorized into low, intermediate and high subgroups. Univariate and multivariate regression analyses were performed to assess the effects of age, gender, ethnicity, and dialysis vintage on the association between HRQOL and educational level. RESULTS: One hundred twenty-nine chronic dialysis patients were included. Patients with an intermediate educational level had significantly higher odds of a higher emotional well-being than patients with a low educational level 4.37 (1.-89-10.13). A similar trend was found for a high educational level (OR 4.13 (1.04-16.42), p = 0.044) The odds for women compared to men were 2.83 (1.32-6.06) for better general health and 2.59 (1.15-5,84) for emotional well-being. There was no interaction between gender and educational level for both subdomains. Each year of increasing age significantly decreased physical functioning (OR 0.94 (0.91-0.97)). CONCLUSIONS: Educational level and sex were associated with emotional well-being, since patients with intermediate and high educational level and females had better emotional well-being in comparison to patients with low educational level and males. Physical functioning decreased with increasing age.

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PURPOSE: Breast cancer (BC) characteristics are known to influence patients survival. Social differences have been reported by previous studies for those characteristics but questions persist because of inconsistent conclusions. We aimed to investigate the impact of education on BC stage, grade, and hormone receptor (HR) status, while adjusting for potential confounders including a broad set of health behaviors, anthropometric measures, and reproductive factors. METHODS: In the French E3N cohort, 5236 women developed a primary invasive BC for which there was available information on stage, grade, and HR status. No multivariate analyses was performed for BC stage based on the lack of association in bivariate analyses. Odds ratios and confidence intervals were estimated using multinomial logistic regression models for BC grade or binomial logistic regression models for HR status of BC. RESULTS: Women with a lower education were diagnosed with higher grade BC compared to women with a higher education (1.32 [1.12; 1.57]). This association was slightly attenuated after adjustment for covariates independently and more strongly affected in the fully adjusted model (1.20 [0.99; 1.45]). A significant association was observed between lower education and HR- status of BC (1.20 [1.02; 1.42]) attenuated after adjustment for age at first childbirth (1.12 [0.95; 1.33]). CONCLUSION: In this cohort, education was associated with BC grade and HR status but not stage at diagnosis. The link between education and BC grade was not entirely explained by the different adjustments. A specific mechanism could be at play and deserves further investigations.

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Background: Working memory is a crucial element of cognitive function. Previous cross-sectional studies have identified various determinants of working memory in children and adolescents. Nonetheless, no study has yet demonstrated the causal relationship of social determinants with working memory in adolescents. Objective: This study explores the causal link between the level of education, smoking, and other factors with adolescent's working memory. Methods: This study analyzed secondary data from waves 4 and 5 of the Indonesia Family Life Survey (IFLS), utilizing cross-lagged analysis in Jamovi version 2.4.8. The variables included working memory score, maternal education, household income, stress, educational level, smoking, urbanicity, and physical activity. These variables were extracted from IFLS waves 4 and 5, and each dependent variable in IFLS wave four was controlled by the same dependent variables in IFLS 5. Then, we used cross-lagged analysis to assess the causality between each dependent variable and a working memory score in IFLS wave 5. Result: The findings indicate that level of education had a positive impact on working memory in adolescents aged 15-18 years, with a Beta value of 0.18 (95% CI 0.81-0.2; p < 0.001). Smoking and age were negatively associated with working memory, with Beta values of -0.07 (95% CI -0.65 -0.04; p < 0.029) and - 0.10 (95% CI -0.25 -0.05; p < 0.003), respectively. No evidence was found for a significant correlation between poverty and adolescents's working memory. Conclusion: The findings indicate that increased education levels are associated with improved working memory in adolescents aged 15-18. At the same time, smoking has a negative impact on working memory in this age group.

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Background: The exposure of pregnant women to multiple environmental pollutants may be more disadvantageous to birth outcomes when compared to single-compound contaminations. Objective: This study investigated the mixed exposures to mercury, manganese, or lead in 380 pregnant Surinamese women. The factors that might be associated with the heavy metal exposures and the relative risk of the potential factors to cause the mixed exposures were explored. The influencing factors of exposures to mixed contaminants assessed were living in Suriname's rural regions, several parts of which are contaminated with heavy metals emitted from artisanal and small-scale gold mining and agricultural activities; the consumption of potentially contaminated foods; advanced maternal age; as well as a relatively low formal educational level and monthly household income. Methods: Descriptive statistics were used to calculate frequency distributions and χ2-contingency analyses to calculate associations and relative risks (RR) with 95% confidence intervals (CI). Findings: Blood levels of two or three of the heavy metals above public health limits were observed in 36% of the women. These women were more often residing in the rural regions, primarily consumed potentially contaminated food items, were 35 years or older, were lower educated, and more often had a lower household income. However, only living in the rural regions (RR = 1.48; 95% CI 1.23-1.77) and a low household income (RR = 1.38; 95% CI 1.15-1.66) significantly increased the risk of exposure exceeding levels of concern to two or three of the heavy metals (by 48% and 38%, respectively). Conclusion: More comprehensive pharmacological, ecological, and epidemiological studies about exposures to mixed heavy metal contaminations in pregnant women are warranted.

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BACKGROUND: Sexually transmitted diseases (STDs) are a global issue facing the world. In a conservative community like Saudi Arabia, discussing such matters is considered taboo, and this might impact the awareness of STDs. Therefore, this study aims to determine if gender, level of education, and university affiliation influence the level of awareness of STDs. METHODS: This research is a cross-sectional study that involves 389 students who are studying at King Saud University (KSU) and Imam Mohammad Ibn Saud Islamic University (IMAMU). Twenty-six questions were gathered from a previous study and implemented into the questionnaire and were validated after. RESULTS: Overall, awareness about STDs was poor. Females scored higher than male participants (7.9 ± 3.3 vs. 7.1 ± 3.2, p < 0.017) respectively. Interestingly, undergraduates scored higher than postgraduates (4.7 ± 3.7 vs. 3.7 ± 3.3, p < 0.029). For the university, KSU students scored higher than their counterparts did at IMAMU (10.4 ± 5.7 vs. 8.9 ± 5.5, p < 0.01). CONCLUSION: Female participants have shown a higher level of STD awareness than males, but the overall awareness is still extremely low. However, KSU scored higher than IMAMU As a result, appropriate education and promotion efforts about STDs must be implemented based on gender and education level.

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BACKGROUND: Preterm children are at increased risk of cognitive and language delay compared with term-born children. While many perinatal factors associated with prematurity are well established, there is limited research concerning the influence of the socio-familial environment on the development of preterm children. This study aims to assess the relative impact of perinatal and socio-familial risk factors on cognitive and language development at 2 years corrected age (CA). METHOD: This retrospective cross-sectional study included preterm infants with a gestational age <32 weeks and/or a birth weight <1500 g, who underwent neurodevelopmental assessment at 2 years CA. Cognitive and language scores were assessed using the Bayley Scales of Infant-Toddler Development, third edition. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) were calculated using a multivariable model to examine the relationship between developmental delays and perinatal and socio-familial factors. RESULT: The prevalence of language delay was negatively associated with daycare attendance (aOR: 0.25, 95% CI: 0.07-0.85, p < 0.05) and high maternal educational levels (aOR: 0.24, 95% CI: 0.05-0.93, p < 0.05) and positively associated with bilingual environments (aOR: 5.62, 95% CI: 1.46-24.3, p < 0.05). Perinatal and postnatal risk factors did not show a significant impact on cognitive or language development. CONCLUSION: The development of language appears to be more influenced by the socio-familial environment than by early perinatal and postnatal factors associated with prematurity. These findings highlight the importance of considering socio-familial factors in the early identification and intervention of language delay among preterm children.

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OBJECTIVE: The objective of this work was to study mortality increase in Spain during the first and second academic semesters of 2020, coinciding with the first 2 waves of the Covid-19 pandemic; by sex, age, and education. METHODS: An observational study was carried out, using linked populations and deaths' data from 2017 to 2020. The mortality rates from all causes and leading causes other than Covid-19 during each semester of 2020, compared to the 2017-2019 averages for the same semester, was also estimated. Mortality rate ratios (MRR) and differences were used for comparison. RESULTS: All-cause mortality rates increased in 2020 compared to pre-covid, except among working-age, (25-64 years) highly-educated women. Such increases were larger in lower-educated people between the working age range, in both 2020 semesters, but not at other ages. In the elderly, the MMR in the first semester in women and men were respectively, 1.14, and 1.25 among lower-educated people, and 1.28 and 1.23 among highly-educated people. In the second semester, the MMR were 1.12 in both sexes among lower-educated people and 1.13 in women and 1.16 in men among highly-educated people. CONCLUSION: Lower-educated people within working age and highly-educated people at older ages showed the greatest increase in all-cause mortality in 2020, compared to the pre-pandemic period.

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INTRODUCTION: Measuring health-related quality of life (HRQoL) in haemophilia patients provides a comprehensive patient's functional and the impact of the disease and its treatment. AIM: This study aimed to assess the HRQoL of haemophilia children and related factors. METHODS: We conducted a cross-sectional study from 6 April 2019 to 29 April 2019. We recruited children aged 8-16 years old who were members of the Yogyakarta Province Branch, Indonesian Haemophilia Society. Children filled in the Indonesian Haemo-QoL short-version questionnaire that consists of nine dimensions, and the score ranges from 0 to 100, in which a higher score shows a higher impartment. RESULTS: Forty-four children participated in this study. The mean age was 11.99 + 2.49. The median age of the first bleeding episode was 5 years, and the median frequency of spontaneous bleeding during the previous year was 13.5. All children received antihemophilic factor (AHF) on-demand; most (81.8%) received AHF in the advanced symptoms. The mean total score of HRQoL was 42.7 ± 15.5, with the highest impairment in the family dimension, with a mean score of 68.0 ± 22.3. The severity of haemophilia was significantly correlated with the total score of HRQoL and dimensions of physical health, feeling, view, and family (effect size ranges from 0.30 to 0.42). The frequency of bleeding was significantly related to the total score of HRQoL and the feeling dimension (effect size of 0.47 and 0.34). CONCLUSION: The HRQoL of our study was lower than in countries where AHF prophylactic is provided. More severe haemophilia and more frequent bleeding significantly lower HRQoL.

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AIMS: The influence of social determinants of health (SDOH) on the prognosis of Heart Failure and reduced Ejection Fraction (HFrEF) is increasingly reported. We aim to evaluate the contribution of educational status on outcomes in patients with HFrEF. METHODS: We used data from the WARCEF trial, which randomized HFrEF patients with sinus rhythm to receive Warfarin or Aspirin; educational status of patients enrolled was collected at baseline. We defined three levels of education: low, medium and high level, according to the highest qualification achieved or highest school grade attended. We analysed the impact of the educational status on the risk of the primary composite outcome of all-cause death, ischemic stroke (IS) and intracerebral haemorrhage (ICH); components of the primary outcome were also analysed as secondary outcomes. RESULTS: 2295 patients were included in this analysis; of these, 992 (43.2%) had a low educational level, 947 (41.3%) had a medium education level and the remaining 356 (15.5%) showed a high educational level. Compared to patients with high educational level, those with low educational status showed a high risk of the primary composite outcome (adjusted hazard ratio [aHR]: 1.31, 95% confidence intervals [CI] 1.02-1.69); a non-statistically significant association was observed in those with medium educational level (aHR: 1.20, 95%CI: .93-1.55). Similar results were observed for all-cause death, while no statistically significant differences were observed for IS or ICH. CONCLUSION: Compared to patients with high educational levels, those with low educational status had worse prognosis. SDOH should be considered in patients with HFrEF. CLINICAL TRIAL REGISTRATION: NCT00041938.

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To assess the effect of the plate model on the remission of diabetes and the demand for hypoglycemic drugs in China. We selected 456 participants with newly diagnosed type 2 diabetes and not required to take hypoglycemic drugs at baseline. The plate education model consists of three parts: a colored leaflet suitable for low literacy reading, regular medical visits and health education sessions. The primary outcomes were remission of diabetes and the time to first use of hypoglycemic drugs. The study was ended after 8.1 years of follow-up. The incidence of the using hypoglycemic drugs was 36.15 % in the plate model, and 75.54 % in the low-fat model (P < 0.001). The prevalence of any remission in plate model was 27.1 % (95 % CI 16.8-37.4 %) during the first 2 years, decreasing to 14.5 % (95 % CI 6.3-22.7 %) during year 4, to 10.1 % (95 % CI 4.4-15.8 %) during year 6, and to 9.6 % (95 % CI 5.3-13.9 %) during year 8, compared with 12.2 % (95 % CI 5.2-19.2 %) at year 2, 6.1 % (95 % CI 2.1-10.1 %) at year 4, 4.7 %(95 % CI 2.2-7.2 %) at year 6, and 2.6 % (95 % CI 1.1-4.2 %) at year 8 in the low-fat group. The HbA1c of plate group was significantly decreased at the endpoint (7.74 ± 0.45 % vs. 6.70 ± 0.46 %, P < 0.001). The plate model may significantly improve the remission rate of diabetes, delay the demand for diabetes drugs, more suitable for patients with low educational level, and reduce the long-term level of HbA1c. Clinical trials registry: The study was registered at ChiCTR (www.chictr.org.cn) (ChiCTR1900027097).

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BACKGROUND: At present, extended reality technologies such as virtual reality (VR) have gained popularity in orthopedic surgery. The first aim of this study was to assess the precision of VR and other imaging modalities - computed tomography (CT), magnetic resonance imaging (MRI) - to localize bony landmarks near the knee joint. Secondly, the impact of the educational level of the assessor - medical master students, orthopedic residents, and orthopedic surgeons - on the precision with which landmarks near the knee joint could be localized was analyzed. METHODS: We included a total of 77 participants: 62 medical master students, 10 orthopedic residents, and 5 orthopedic surgeons to analyze three cadaver legs. Every participant localized a series of sixteen bony landmarks on six different imaging modalities (CT, MRI, 3D-CT, 3D-MRI, VR-CT, VR-MRI). RESULTS: Concerning the imaging modality, the inter- and intra-observer variability were lowest for 3D and VR, higher for MRI (respectively 7.6 mm and 6.9 mm), and highest for CT (respectively 9 mm and 8.7 m).Concerning the educational level of the assessor, inter- and intra-observer variability in VR were lowest for surgeons, (respectively 3.2 mm and 3.6 mm), higher for residents (respectively 5.9 mm and 6.5 mm) and medical students (respectively 5.9 mm and 5.8 mm). CONCLUSIONS: VR can be considered a reliable imaging technique. Localization of landmarks tends to be more precise in VR and on 3D than on conventional CT and MRI images. Furthermore, orthopedic surgeons localize landmarks more precisely than orthopedic residents and medical students in VR.

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Introducción: Las variables sociodemográficas y las patologías orales influyen en el estado nutricional. Objetivo: Determinar la relación entre características sociodemográficas, estado nutricional y salud oral. Métodos: En 2022 se realizó un estudio observacional descriptivo en 24 adultos masculinos de entre 31 y 62 años, de Yaguajay, Sancti Spíritus. Se aplicaron cuestionarios, mediciones antropométricas y exámenes orales. En SPSS versión 21 fueron resumidas las variables mediante frecuencias absolutas y relativas, el promedio y la desviación estándar, según correspondió. Para el estudio multivariado se utilizó el análisis de correlación canónica no lineal. Resultados: En la primera dimensión, las variables con saturaciones ≥ 0,5 que mostraron asociaciones fueron: grupo etario, nivel educacional, índice de masa corporal, dientes perdidos por caries y total de dientes perdidos. En la segunda dimensión, las variables que mostraron relación fueron: circunferencia de la cintura y dientes perdidos por caries. Adultos de 50 años o más presentaron pérdidas de 10 o más dientes. Se verificó la asociación entre la pérdida por caries de 10 o más dientes y la circunferencia de la cintura de 102 cm o más. El 71 % de los sujetos con nivel escolar de secundaria básica fue sobrepeso. El 55 y el 67 %, con nivel preuniversitario y universitario respectivamente, mostraron un índice de masa corporal aceptable. Conclusiones: Las asociaciones reportadas entre las variables socioeconómicas, nutricionales e intraorales señalan la importancia de una educación y promoción para la salud integradoras. La multidisciplinariedad y las estrategias comunes podrían ser más efectivas en la prevención de las enfermedades orales y nutricionales.

Introduction: Socio-demographic variables and oral pathologies influence nutritional status. Objective: To describe the relationship between socio-demographic characteristics, nutritional status, and oral health. Methods: In 2022, a descriptive observational study was conducted on 24 adult males, between 31 and 62 years old, from Yaguajay, Sancti Spíritus. Questionnaires, anthropometric measurements, and oral examinations were applied. In SPSS version21, the variables were summarized using absolute and relative frequencies, mean and standard deviations, as appropriate. Non-linear canonical correlation analysis was used for the multivariate analysis. Results: In the first dimension, the variables with saturations ≥0.5 that showed associations were: age group, educational level, body mass index, teeth lost due to caries and total teeth lost. In the second dimension, the variables that showed associations were: waist circumference and teeth lost due to caries. Adults aged 50 years or older presented losses of 10 or more teeth. The association between caries loss of 10 or more teeth and waist circumference of 102 cm or more was verified. 71% of the subjects with basic secondary school level were overweight. 55% and 67% of those with pre-university and university level respectively showed an acceptable body mass index. Conclusions: The associations reported between socioeconomic, nutritional and intraoral variables point to the importance of integrative health education and promotion. Multidisciplinary and common strategies could be more effective in the prevention of oral and nutritional diseases.