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Education level and biologic therapy are the related factors of mucosal healing in Patients with Crohn's disease.
Zhang, Limin; Yang, Shanbing; Jia, Kangmei; Du, Shuwen; Jia, Yan; Lu, Xiaojuan; Wang, Jiheng.
Afiliación
  • Zhang L; Department of Gastroenterology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China. Electronic address: 873141785@qq.com.
  • Yang S; Department of Gastroenterology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China. Electronic address: piratey@163.com.
  • Jia K; Department of Internal Medicine, Southern Medical district of Chinese PLA General Hospital, Beijing 100000, China.
  • Du S; Department of Gastroenterology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China.
  • Jia Y; Department of Gastroenterology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China.
  • Lu X; Department of Gastroenterology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China.
  • Wang J; Senior Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China; Department of Gastroenterology, The Seventh Medical Center, Chinese PLA General Hospital, Beijing 100700, China. Electronic address: acewjh@aliyun.com.
Arab J Gastroenterol ; 2024 Jul 23.
Article en En | MEDLINE | ID: mdl-39048387
ABSTRACT
BACKGROUND AND STUDY

AIMS:

Mucosal healing (MH) is a crucial indicator of therapeutic effectiveness and prognosis in Crohn's disease (CD). Rapid achievement and long-term maintenance of MH can alleviate the financial and psychological burden on patients. This study aimed to investigate the factors associated with MH in CD patients and enhance clinicians' understanding. PATIENTS AND

METHODS:

Patients diagnosed with CD between January 2010 and December 2019 at our hospital were included and divided into two groups based on the attainment of MH during the follow-up period. Demographic data, symptoms, disease classification, laboratory examination results, and treatments were collected and compared between the two groups. Factors with a P-value <0.2 were subjected to multivariate logistic regression analysis to identify the related factors of MH.

RESULTS:

Multivariate logistic regression analysis of CD patients revealed that educational level [odds ratio (OR) = 8.167, 95 % confidence interval (CI) 1.440-46.303, P = 0.018] and biological therapy (OR = 15.291, 95 % CI 1.404-166.543, P = 0.025) were associated with MH.

CONCLUSION:

Educational level and biological therapy are factors related to MH in CD patients. These findings suggest that the use of biological therapy and patients' better understanding of the disease contribute to achieving MH.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arab J Gastroenterol Año: 2024 Tipo del documento: Article Pais de publicación: Egipto
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Arab J Gastroenterol Año: 2024 Tipo del documento: Article Pais de publicación: Egipto