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This Perspective evaluates recent progress in modeling nature-society systems to inform sustainable development. We argue that recent work has begun to address longstanding and often-cited challenges in bringing modeling to bear on problems of sustainable development. For each of four stages of modeling practice-defining purpose, selecting components, analyzing interactions, and assessing interventions-we highlight examples of dynamical modeling methods and advances in their application that have improved understanding and begun to inform action. Because many of these methods and associated advances have focused on particular sectors and places, their potential to inform key open questions in the field of sustainability science is often underappreciated. We discuss how application of such methods helps researchers interested in harnessing insights into specific sectors and locations to address human well-being, focus on sustainability-relevant timescales, and attend to power differentials among actors. In parallel, application of these modeling methods is helping to advance theory of nature-society systems by enhancing the uptake and utility of frameworks, clarifying key concepts through more rigorous definitions, and informing development of archetypes that can assist hypothesis development and testing. We conclude by suggesting ways to further leverage emerging modeling methods in the context of sustainability science.

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Climate oscillations ranging from years to decades drive precipitation variability in many river basins globally. As a result, many regions will require new water infrastructure investments to maintain reliable water supply. However, current adaptation approaches focus on long-term trends, preparing for average climate conditions at mid- or end-of-century. The impact of climate oscillations, which bring prolonged and variable but temporary dry periods, on water supply augmentation needs is unknown. Current approaches for theory development in nature-society systems are limited in their ability to realistically capture the impacts of climate oscillations on water supply. Here, we develop an approach to build middle-range theory on how common climate oscillations affect low-cost, reliable water supply augmentation strategies. We extract contrasting climate oscillation patterns across sub-Saharan Africa and study their impacts on a generic water supply system. Our approach integrates climate model projections, nonstationary signal processing, stochastic weather generation, and reinforcement learning-based advances in stochastic dynamic control. We find that longer climate oscillations often require greater water supply augmentation capacity but benefit more from dynamic approaches. Therefore, in settings with the adaptive capacity to revisit planning decisions frequently, longer climate oscillations do not require greater capacity. By building theory on the relationship between climate oscillations and least-cost reliable water supply augmentation, our findings can help planners target scarce resources and guide water technology and policy innovation. This approach can be used to support climate adaptation planning across large spatial scales in sectors impacted by climate variability.

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Despite the emerging body of literature on entrepreneurial ecosystems (EEs), theoretical development is still in its infancy. In this article, we explicitly draw upon the analogy of forest ecosystems (FEs) with an EE to extrapolate the regional entrepreneurial ecosystem (REE) as an alternate conceptual framework. The REE considers a region's socioeconomic activity and the stability of its performance as a whole, influenced by partitioned interests of economics, social arrangements, physical environment, knowledge and the technology that each contributes to the community's industry and economic order. We contend that it is when an EE is defined by a regional dimension that it is analogous to the study of forests. In this REE analysis, neither the entrepreneur nor their firm are the unit of analysis, but it is the change and stability of the regional socioeconomic ecosystem itself that becomes the priority. Scholars, interested in the effects of entrepreneurship, can learn from ecological studies to more fully grasp the interplay between compositional, structural, and functional elements and specifically how entrepreneurs account for change dynamics.

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Aims: This study aimed to determine the prevalence of, factors associated with, and to build a theoretical framework for understanding Internalsed HIV-related Stigma Mastery (IHSM). Methods: A cross-sectional study nested within a 2014 Stigma Reduction Cohort in Uganda was used. The PLHIV Stigma Index version 2008, was used to collect data from a random sample of 666 people living with HIV (PLHIV) stratified by gender and age. SPSS24 with Amos27 softwares were used to build a sequential-mediation model. Results: The majority of participants were women (65%), aged ≥ 40 years (57%). Overall, IHSM was 45.5% among PLHIV, that increased with age. Specifically, higher IHSM correlated with men and older women "masculine identities" self-disclosure of HIV-diagnosis to family, sharing experiences with peers. However, lower IHSM correlated with feminine gender, the experience of social exclusion stress, fear of future rejection, and fear of social intimacy. Thus, IHSM social exclusion with its negative effects and age-related cognition are integrated into a multidimensional IHSM theoretical framework with a good model-to-data fit. Conclusion: Internalised HIV-related Stigma Mastery is common among men and older women. Specificially, "masculine identities" self-disclose their own HIV-positive diagnosis to their family, share experiences with peers to create good relationships for actualising or empowerment in stigma mastery. However, social exclusion exacerbates series of negative effects that finally undermine stigma mastery by young feminine identities. Thus, stigma mastery is best explained by an integrated empowerment framework, that has implications for future practice, policy, and stigma-related research that we discuss.

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Globalization has led to an increasing emphasis on the critical role of the workforce in the success of organizations. This has resulted in the shift of focus on human resource development (HRD) as the center of attention in the current paradigm. Hence, this article suggests a need to use a comprehensive philosophical paradigm to develop practical theories in HRD and compares the usefulness of positivism, interpretivism and pragmatism philosophies in the theory-building process. Based on fragmented literature in philosophy and HRD disciplines, this theoretical manuscript has assembled and thoroughly reviewed the existing literature to propose new ways of theory building in HRD. The findings guide that despite the usefulness of positivism and interpretivism philosophical paradigms in knowledge generation, these philosophies lead to practically weak theories. Hence, theory building in HRD should be driven by a problem-solving approach rather than only relying on plausibility criteria. It further guides how multi-method and mixed-method research designs might help provide answers to complex and newly emerged challenges in HRD. Overall, this research adds value to a body of knowledge by proposing a unique five-stage framework to develop new theories in HRD using the pragmatism approach. The use of the proposed framework might be beneficial in developing practically and theoretically useful theories in the future.

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BACKGROUND: Worldwide, the internet is an increasingly important channel for health information. Many theories have been applied in research on online health information seeking behaviors (HISBs), with each model integrating a different set of predictors; thus, a common understanding of the predictors of (online) HISB is still missing. Another shortcoming of the theories explaining (online) HISB is that most existing models, so far, focus on very specific health contexts such as cancer. Therefore, the assumptions of the Planned Risk Information Seeking Model (PRISM) as the latest integrative model are applied to study online HISB, because this model identifies the general cognitive and sociopsychological factors that explain health information seeking intention. We shift away from single diseases and explore cross-thematic patterns of online HISB intention and compare predictors concerning different health statuses as it can be assumed that groups of people perceiving themselves as ill or healthy will differ concerning their drivers of online HISB. Considering the specifics of online HISB and variation in individual context factors is key for the development of generalizable theories. OBJECTIVE: The objective of our study was to contribute to the development of the concept of online HISB in 2 areas. First, this study aimed to explore individual-level predictors of individuals' online HISB intention by applying the postulates of PRISM. Second, we compared relevant predictors of online HISB in groups of people with different health statuses to identify cross-thematic central patterns of online HISB. METHODS: Data from a representative sample of German internet users (n=822) served to explain online HISB intentions and influencing patterns in different groups of people. The applicability of the PRISM to online HISB intention was tested by structural equation modeling and multigroup comparison. RESULTS: Our results revealed PRISM to be an effective framework for explaining online HISB intention. For online HISB, attitudes toward seeking health information online provided the most important explanatory power followed by risk perceptions and affective risk responses. The multigroup comparison revealed differences both regarding the explanatory power of the model and the relevance of predictors of online HISB. The online HISB intention could be better explained for people facing a health threat, suggesting that the predictors adopted from PRISM were more suitable to explain a problem-driven type of information-seeking behavior. CONCLUSIONS: Our findings indicate that attitudes toward seeking health information online and risk perceptions are of central importance for online HISB across different health-conditional contexts. Predictors such as self-efficacy and perceived knowledge insufficiency play a context-dependent role-they are more influential when individuals are facing health threats and the search for health information is of higher personal relevance and urgency. These findings can be understood as the first step to develop a generalized theory of online HISB.

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This article explores the development of a rat model of mother-infant relationships from its origins in the psychosomatic investigations of the mid-1960s to its elaboration into a theoretical system in neurobiology. I reconstruct the research trajectory of a group of neurobiologists in the United States, with a focus on the experimental practices they adopted while building this animal model. Providing a microhistory of this decade-long undertaking, I show that what drove the development of the model in practice was a serendipitous finding about infants' response to maternal separation. Detected inadvertently, the pup's separation response acquired an epistemic significance of its own and reoriented the experimental system towards unanticipated paths. To explain this intriguing phenomenon, the neurobiologists kept on refining their material manipulations and stabilizing their experimental outcomes. They thus established a series of causal relationships that connected dysregulations of the infant's physiological systems to disruptions in maternal care. As important as this interactive stabilization of technique and objects in the laboratory was how the researchers theorized the network of relationships derived from this technically constituted objectivity. Highlighting the practice-driven aspects of model-building, I demonstrate that what facilitated this theoretical process was an integrated design of complementary experiments. The outcome of each separate experiment of the research program came to bear upon the outcomes of other experiments, informing the development of future manipulations. It was this strategically driven integration process that allowed the experimenters to build expanding networks of causal relationships and consolidate them into a neurobiological theory.

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Young children typically begin learning words during their first 2 years of life. On the other hand, they also vary substantially in their language learning. Similarities and differences in language learning call for a quantitative theory that can predict and explain which aspects of early language are consistent and which are variable. However, current developmental research practices limit our ability to build such quantitative theories because of small sample sizes and challenges related to reproducibility and replicability. In this chapter, we suggest that three approaches-meta-analysis, multi-site collaborations, and secondary data aggregation-can together address some of the limitations of current research in the developmental area. We review the strengths and limitations of each approach and end by discussing the potential impacts of combining these three approaches.

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In this theory-building case study, we investigate Blatt's two-polarity model of personality development according to which psychopathology is a consequence of an unbalance between the two developmental lines of interpersonal relatedness and self-definition. Anaclitic psychopathology, such as schizophrenia, histrionic, dependent, and borderline personality disorders, is associated with an excessive and rigid emphasis on interpersonal relatedness. In this theory-building case study, we examine whether this model can be extended to dissociative identity disorder (DID). The patient is a 23-year old Caucasian man who suffers from periodic episodes of dissociation. Consensual qualitative research for case studies is used to quantitatively and qualitatively describe the interplay between symptomatic and interpersonal evolutions throughout 41 sessions of supportive-expressive psychoanalytic psychotherapy. In line with the two-polarity model of personality development, close associations between symptoms of dissociation and dependent interpersonal dynamics were observed. Psychoanalytic interventions focusing on elaboration of the subjective meanings of (past and anticipated) dissociations, and on working through core interpersonal conflicts, are followed by transformations in the patient's interpersonal stances and subjective well-being. No new dissociative episodes were reported during the follow-up assessment three and a half years after the completion of treatment. This case study demonstrates that DID is a form of anaclitic psychopathology as it is associated with a predominant tendency to interpersonal relatedness.

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BACKGROUND: Groups at risk of exclusion from society appear to have a lower health status and more health-related problems. Prevention efforts in these groups are not always successful, and new ways have to be sought by which health messages can be delivered. Many agree on low-threshold sport activities, also called 'community sports', to be a powerful tool to target socially vulnerable groups. Until now, it has not been investigated how and when such sport initiatives may be able to impact health outcomes in socially vulnerable populations. This study aims at developing a program theory that clarifies the mechanisms and necessary conditions for sport programs to be effective in health promotion. Such a program theory may constitute a backbone for developing health promotion initiatives within a sport for development setting. METHODS: We developed a program theory using a realist research design. We build on an extensive data set consisting of the insights of key stakeholders and participants of various community sport organizations at the one hand, and on relevant theoretical frameworks at the other hand. Data were collected through participatory observations of soccer trainings and related group activities, interviews with key stakeholders and participants, document analysis and two focus groups with stakeholders from associated social partnership organizations. RESULTS: The health promoting effect of community sport on socially vulnerable groups seems not to result from an improved physical condition or sport-technical skills as such, but from processes of experiential learning among peers, incremental responsibility-taking and reflexivity. On the condition that participants feel safe, are stimulated to reflect and enabled to become actor of themselves and their situation, these processes are likely to lead to increased self-esteem, self-efficacy and motivation to set and pursue personal (health) goals. The key-influencing factor in these processes is the coach, who therefore needs to be adequately skilled in, for example, social vulnerability, motivational coaching and group dynamics. CONCLUSIONS: The program theory developed in this study offers insights in the mechanisms proper to, and necessary conditions for community sport to be a lever for health promotion in socially vulnerable groups. Motivational processes at individual level and group connectivity are at the basis of personal health goal-setting. One of the necessary conditions is that these processes are guided by community sport coaches skilled in the meaning and impact of social exclusion, and capable of connecting with the target group.

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Crises in science concern not only methods, statistics, and results but also, theory development. Beyond the indispensable refinement of tools and procedures, resolving crises would also benefit from a deeper understanding of the concepts and processes guiding research. Usually, theories compete, and some lose, incentivizing destruction of seemingly opposing views. This does not necessarily contribute to accumulating insights, and it may incur collateral damage (e.g., impairing cognitive processes and collegial relations). To develop a more constructive model, we built on adversarial collaboration, which integrates incompatible results into agreed-on new empirical research to test competing hypotheses [D. Kahneman, Am. Psychol. 58, 723-730 (2003)]. Applying theory and evidence from the behavioral sciences, we address the group dynamic complexities of adversarial interactions between scientists. We illustrate the added value of considering these in an "adversarial alignment" that addressed competing conceptual frameworks from five different theories of social evaluation. Negotiating a joint framework required two preconditions and several guidelines. First, we reframed our interactions from competitive rivalry to cooperative pursuit of a joint goal, and second, we assumed scientific competence and good intentions, enabling cooperation toward that goal. Then, we applied five rules for successful multiparty negotiations: 1) leveling the playing field, 2) capitalizing on curiosity, 3) producing measurable progress, 4) working toward mutual gain, and 5) being aware of the downside alternative. Together, these guidelines can encourage others to create conditions that allow for theoretical alignments and develop cumulative science.

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In the last part of our Essay, we outline a future of consilience, with a role both for fact-seekers, and for searchers for understanding. We begin by looking at theory and simulation, surrounded as they are by and interacting with experiment, especially in Chemistry. Experimenters ask questions both conceptual and numerical, and so draw the communities together. Two case studies show what brings the theoretician authors joy in this playground, and two more detailed ones make it clear that computation/simulation is anyway deeply intertwined with theory-building in what we do, or for that matter, anywhere in the profession. From a definition of science we try to foresee how simulation and theory will interact in the AI-dominated future. We posit that Chemistry's streak of creation provides in that conjoined future a link to Art, and a passage to a renewed vision of the sacred in science.

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Resumen Desde la teoría del cambio subjetivo en psicoterapia, este estudio de caso constructor de teoría examina cualitativamente el proceso de cambio de una terapia exitosa. El estudio caracteriza micro-prácticas conversacionales que aparecen en episodios de cambio (EC). Los EC son segmentos de conversación teóricamente vinculados al cambio terapéutico, dado que en ellos aparecen indicadores genéricos de cambio en tres niveles: entrada, proceso, y salida. Se exploraron aquí los 16 episodios conteniendo indicadores genéricos de proceso (nivel 2). Como resultado se describen seis supuestos terapéuticos que facilitaron el logro de autorreferencias preferidas (ARP) en los EC de proceso. Se discute cómo esta caracterización contribuye a comprender la elaboración (subjetiva) de una "teoría" sobre el propio cambio terapéutico como resultado del proceso (intersubjetivo) de clarificar y validar ARP para y con el terapeuta. En este sentido, el estudio permite dar mayor especificidad a la teoría del cambio subjetivo desde el punto de vista del proceso conversacional que con-instituye o legitima el cambio.

Abstract Drawing from the theory of subjective change in psychotherapy, this theory-building case study examines one successful therapeutic change process. The study characterizes conversational micro-practices featuring in segments of conversation theoretically linked to therapeutic change called change episodes (CE), containing three types of observable generic indicators of change: input, process, and output. For this study the 16 CE containing indicators of the second level (process) were examined. Six conversational practices involving six therapeutic assumptions are presented as a result of the study, which were consequential in discursively accomplishing preferred self-references (PSR) within CE related to process. Given that generating a "subjective theory" about the client's own change process emerges as a byproduct of conversationally clarifying PSR for and with the therapist (i.e., intersubjective validation), this study contributes further specifying the theory of subjective change.

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This article is devoted to the topic of the conditions for a constructive interdisciplinary dialogue between psychoanalytic theory and practice and research in mind disciplines neighbouring psychoanalysis applied to the concept of psychoanalytic process. The first section reviews the contemporary controversy about psychoanalysis and research and the contributions that different disciplines-such as empirical research in progress in psychotherapy and psychoanalysis, in attachment and the early mother-infant relationship, and neurosciences-propose for the construction of theory in psychoanalysis. The gaps in the scientific investigation of central aspects of the psychoanalytic conception are highlighted, such as the dyadic nature of the construction of the experience in therapy and the relationship between the implicit and explicit levels of the analytic relationship. The article concludes by laying the foundations for a novel research programme for psychoanalysis that addresses the outstanding gaps.

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Abstract The highest-order function of the mind is as a theorist. The memory system accumulates information about the outside world. The mind's theorist must sort through the information to formulate a theory about that world. The basic component of the system for theory building is a process called trolling. When the conscious mind is not being bombarded by external stimuli, or during certain stages of sleep, the mind's theorist trolls through memory searching for traces that contain similar information. If several traces are identified, analysis may yield information that was not evident when each was examined individually; reification of this sort can add new information to memory. The trolling process, and its ability to form new memory traces in the absence of external stimulation, is key to understanding many psychological phenomena.

Resumen La función superior de la mente es la de la construcción teórica. El sistema de memoria acumula información acerca del mundo externo y la mente constructora de teorías debe revisar dicha información para formular una teoría sobre el mundo. El componente básico del sistema de construcción teórica es un proceso llamado "trolling", que implica una búsqueda cuidadosa y sistemática. Cuando la mente consciente no está siendo bombardeada por estímulos externos o durante ciertas etapas del sueño, la mente teórica escudriña en la memoria buscando trazas que contengan información similar. Cuando se identifican varias trazas, es posible que el análisis arroje información que no era evidente al examinar cada traza de manera individual. Así, este tipo de reificación puede aportarle nueva información a la memoria. Dada su capacidad de formar nuevas trazas de memoria en ausencia de estímulos externos, el proceso de "trolling" es clave para la comprensión de muchos fenómenos psicológicos.

Resumo A maior função superior do cérebro é a de ser um teórico. O sistema da memória acumula informação sobre o mundo de fora. O teórico da mente deve investigar toda a informação para formular uma teoria sobre esse mundo. O componente básico do sistema para elaborar teorias é um processo chamado "trolling" (pesca de corrico). Quando a mente consciente não está sendo bombardeada por estímulos externos, ou durante certas etapas do sono, o teórico da mente "pesca" pelas memórias, procurando traços que contenham informações parecidas. Se vários traços são identificados, pode-se ter como resultado informação que não era evidente quando cada um foi analisado individualmente; reificação desse tipo pode adicionar nova informação à memória. O processo de "pescar" e sua habilidade para formar novos traços de memória na ausência de estímulos externos é fundamental para entender muitos fenômenos psicológicos.

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The classical symptom specificity hypothesis (Blatt, 1974) particularly associates obsessional symptoms to interpersonal behavior directed at autonomy and separation from others. Cross-sectional group research, however, has yielded inconsistent findings on this predicted association, and a previous empirical case study (Cornelis et al., in press; see Chapter 2) documented obsessional pathology to be rooted in profound ambivalences between autonomous and dependent interpersonal dynamics. Therefore, in the present empirical case study, concrete operationalizations of the classical symptom specificity hypothesis are contrasted to alternative hypotheses based on the observed complexities in Chapter 2. Dynamic associations between obsessional symptoms and interpersonal functioning is further explored, aiming at further contribution to theory building (i.e., through suggestions for potential hypothesis-refinement; Stiles, 2009). Similar to the first empirical case study (Chapter 1), Consensual Qualitative Research for Case studies is used to quantitatively and qualitatively describe the longitudinal, clinical interplay between obsessional symptoms and interpersonal dynamics throughout the process of supportive-expressive psychodynamic therapy. In line with findings from Chapter 1, findings reveal close associations between obsessions and interpersonal dynamics, and therapist interventions focusing on interpersonal conflicts are documented as related to interpersonal and symptomatic alterations. Observations predominantly accord to the ambivalence-hypothesis rather than to the classical symptom specificity hypothesis. Yet, meaningful differences are observed in concrete manifestations of interpersonal ambivalences within significant relationships. Findings are again discussed in light of conceptual and methodological considerations; and limitations and future research indications are addressed.

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OBJECTIVE: Notwithstanding consistent findings of significant relationships between the alliance and outcome, questions remain to be answered about the relatively small magnitude of those correlations, the mechanisms underlying the association, and how to conceptualize the alliance construct. We conducted a preliminary study of an approach to the alliance based on interpersonal defense theory, which is an interpersonal reconceptualization of defense processes, to investigate the promise of this alternative approach as a way to address the outstanding issues. METHOD: We employed qualitative, theory-building case study methodology, closely examining alliance processes at four time points in the treatment of a case in terms of a case formulation based on interpersonal defense theory. RESULTS: The results suggested that our approach made it possible to recognize key processes in the alliance and that it helps explain how the alliance influences outcome. Our analyses also provided a rich set of concrete illustrations of the alliance phenomena identified by the theory. CONCLUSIONS: The findings suggest that an approach to the alliance based on interpersonal defense theory holds promise. However, although the qualitative method we employed has advantages, it also has limitations. We offer suggestions about how future qualitative and quantitative investigations could build on this study.

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About 25 years ago, concept mapping was introduced in the Netherlands and applied in different fields. A collection of concept mapping projects conducted in the Netherlands was identified, in part in the archive of the Netherlands Institute of Mental Health and Addiction (Trimbos Institute). Some of the 90 identified projects are internationally published. The 90 concept mapping projects reflect the changes in mental health care and can be grouped into 5-year periods and into five typologies. The studies range from conceptualizing the problems of the homeless to the specification of quality indicators for treatment programs for patients with cystic fibrosis. The number of concept mapping projects has varied over time. Growth has been considerable in the last 5 years compared to the previous 5 years. Three case studies are described in detail with 12 characteristics and graphical representations. Concept mapping aligns well with the typical Dutch approach of the "Poldermodel." A broad introduction of concept mapping in European countries in cooperation with other countries, such as the United States and Canada, would strengthen the empirical basis for applying this approach in health care policy, quality, and clinical work.

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Since emergence of the field 'Educational Neuroscience' (EN) in the late nineties of the previous century, a debate has emerged about the potential this field holds to influence teaching and learning in the classroom. By now, most agree that the original claims promising direct translations to teaching and learning were too strong. I argue here that research questions in (health professions) education require multi-methodological approaches, including neuroscience, while carefully weighing what (combination of) approaches are most suitable given a research question. Only through a multi-methodological approach will convergence of evidence emerge, which is so desperately needed for improving teaching and learning in the classroom. However, both researchers and teachers should become aware of the so-called 'seductive allure' of EN; that is, the demonstrable physical location and apparent objectivity of the measurements can be interpreted as yielding more powerful evidence and warranting stronger conclusions than, e.g., behavioral experiments, where in fact oftentimes the reverse is the case. I conclude that our tendency as researchers to commit ourselves to one methodological approach and to addressing educational research questions from a single methodological perspective is limiting progress in educational science and in translation to education.

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