RESUMEN

BACKGROUND: Riding lawn mower injuries are the most common cause of major limb loss in young U.S. children. Our study objective was to investigate the circumstances surrounding pediatric riding lawn mower injuries and to identify potential contributing risk factors and behaviors leading to these events. METHODS: Followers/members of both a public and a private lawn mower injury support and prevention Facebook page who had or were aware of children who had suffered a lawn mower-related injury were invited to complete an electronic survey on Qualtrics. Duplicate cases and those involving push mowers were removed. Frequencies and chi-square analyses were performed. RESULTS: 140 injured children were identified with 71% of surveys completed by parents and 19% by an adult survivor of a childhood incident. The majority of injured children were Caucasian (94%), male (64%), and ≤ 5 years of age at the time of the incident (63%). Bystanders were 69% of those injured, 24% were lawn mower riders, and mower operators and others accounted for 7%. The lawn mower operator was usually male (77%), being the father/stepfather in almost half. Overall, 59% of injuries occurred while traveling in reverse, 29% while moving forward. Nearly all (92%) had an amputation and/or permanent disability. Subgroup analysis (n = 130) found injured bystanders were younger than injured passengers with 71% versus 45% being < 5 years of age, respectively (p = 0.01). Over three-quarters of bystander incidents occurred while moving in reverse as compared to 17% of passenger incidents (p < 0.01). Amputations and/or permanent disabilities were greater among bystanders (97%) as compared to passengers (79%, p = 0.01). Only 3% of bystanders had an upper extremity injury as compared to 21% of passengers (p = 0.01). Seventy-three percent of bystander victims had received at least one ride on a lawn mower prior to their injury incident. CONCLUSIONS: Child bystanders seriously injured by riding lawn mowers were frequently given prior rides likely desensitizing them to their inherent dangers and leading them to seek rides when mowers were being used. Engineering changes preventing blade rotation when traveling in reverse and not giving children rides (both when and when not mowing) may be critical in preventing mower-related injuries.

RESUMEN

Coronavirus has had a large-scale impact on transportation. This study attempts to assess the effects of COVID-19 on biking. Bikeshare data was used to understand the impacts of COVID-19 during the initial wave of the disease on biking in New York City, Boston, and Chicago. As the cases increased, these cities experienced a reduction in bikeshare trips, and the reductions were different in the three cities. Correlations were developed between COVID-19 cases and various bikeshare related variables. The study period was split into three phases-no COVID-19 phase, cases increasing phase, and cases decreasing phase-to examine how the residents of the three cities reacted during the different phases of the coronavirus spread. While bike trips decreased, the average duration of the trips increased during the pandemic. NYC's average trip duration was consistently less than that of Boston and Chicago, which could be due to its sprawl (NYC is considered as more compact and connected compared to the other two cities).

RESUMEN

INTRODUCTION: Studies have shown that approximately half of arrested intoxicated drivers had their last alcoholic drink at a licensed bar or restaurant. Current efforts to prevent intoxicated patrons from leaving licensed establishments and driving home have been only partially successful. Since a high proportion of drinkers drive to their drinking destination, promoting the use of alternative transportation (AT) - including safe ride shuttles, free or subsidized taxi and ridesharing services, voluntary or paid designated driver programs, and more accessible public transportation - is an important strategy for preventing impaired driving. The primary goal of this study was to review and synthesize the findings of research studies designed to test the effectiveness of AT programs in reducing alcohol-impaired driving. A secondary goal was to report if using AT has led to any unintended consequences, in particular greater alcohol consumption. METHOD: We identified relevant academic articles, new articles, government reports, and other documents (English only) through the University of Chicago library, Google Scholar, and Google Search. We also included published articles recommended by peers. Key search terms included: alternative transportation; safe rides; designated driver; alcohol-impaired driving; alcohol consumption, cost effectiveness; and reduce drunk driving. Initially, we identified 168 potentially relevant sources, of which only 57 were academic articles. After a thorough review, we narrowed down the number of relevant articles to 125 including some background articles and government reports. RESULTS: Some AT programs produced reductions in one or more of the following outcomes: (1) impaired driving; (2) impaired driving crashes; (3) driving under the influence (DUI) arrests; and (4) traffic crashes in general, but others were not shown to be effective. A few programs resulted in greater self-reported alcohol use, but there were no significant findings indicating that drinking when using AT led to an increase in alcohol-related harms such as public intoxication, assaults, or other alcohol-related crime. Of the studies that conducted a cost-benefit analysis, most showed that AT programs yielded a positive benefit, but these studies did not include a sufficient number of variables to be considered true cost-benefit analyses. CONCLUSIONS: There is mixed evidence regarding the effectiveness of AT programs. Evaluations with more rigorous quasi-experimental and experimental designs are needed to identify which types of AT programs work best for different types of communities and target groups. Practical Applications: The literature review and synthesis revealed that the most successful AT programs typically have some of these attributes: (1) social acceptance; (2) high level of public awareness; (3) low cost; (4) year-round availability; (5) provide rides to and from drinking venues; (6) several sponsors that provide funding); (7) user convenience; and (8) perceived safety.

Asunto(s)

RESUMEN

INTRODUCTION: Scrotal rejuvenation is a real male aesthetic demand. Scrotal injection of botulinum toxin makes the testicles smoother, less dangling and subjectively larger. METHODS: Intrascrotal botulinum toxin injections were performed to a 44-year-old patient for aesthetic purposes. We used the intracremasteric injection protocol. Cremaster muscle injections and dartos muscle injections were performed. RESULTS: The patient was satisfied. No adverse reaction to the intrascrotal botulinum toxin injection was observed. The patient wanted to repeat the procedure in the future. CONCLUSION: At the moment, there is no recommendation about the aesthetic use of intrascrotal injections of botulinum toxin A and the risks are unknown. The purpose of this article is to show the feasibility, context and technical modalities of intrascrotal injection. The risk of infertility is real, but marginal for men who no longer have progeny's desire. LEVEL OF EVIDENCE: Level 3.

Asunto(s)

RESUMEN

OBJECTIVE: Emulsified fat injection showed its interest in aesthetic facial surgery. The adipose tissue harvested is mechanically emulsified and filtered. The suspension obtained is injected into the dermis through small diameter needles (27 to 30 gauges). The objective of our study was to evaluate the biological composition of emulsified fat and its clinical effectiveness in the treatment of peri-oral wrinkles in 4 patients aged 50 to 59 years. MATERIAL AND METHOD: Each patient received an intradermal injection of emulsified fat in the peri-oral wrinkles prepared from abdominal fat under local anesthesia. The cell viability, stromal vascular fraction (FVS) composition in emulsified fat and the adipocyte differentiation capacity of mesenchymal stem cells (MSC) were studied. The clinical results were evaluated by standardized photographs, 3D microphotography, confocal microscopy, and self-evaluation of patient satisfaction over a period of 4 months. RESULTS: The biological study of the emulsified fat found a lysis of all the adipocytes. The mean number of FVS cells was 126,330±2758 cells by cc of emulsified fat with preserved cell viability (85.1±6.84 %) and a good proportion of regeneratives cells (18.77±6.2 %). The clinical study found a tendency to decrease the volume of wrinkles on standardized photography and 3D microphotography no significative. Patients were satisfied with treatment with an average score of 7±1.15/10 to 4 months. CONCLUSION: Intradermal injection of emulsified fat seems to be an interesting treatment of face wrinkles. Our study has shown its safety, but additional studies seems necessary to confirm its clinical efficacy.

Asunto(s)

RESUMEN

OBJECTIVE:To study the effects of different drying technologies and slicing on the quality of Tetrastigma hemsley-anum,and optimize the drying methods for T. hemsleyanum. METHODS:2 treatment methods(slicing and no slicing)and 5 dry-ing methods(drying in the shade,drying in the sunlight,hot-air drying,microwave drying and freeze drying)were respectively ad-opted for the T. hemsleyanum root. After drying for 3.5-213.0 h,using the total flavonoids,total polyphenols,polysaccharides andβ-sitosterol as indexes,effects of different drying technologies on the quality of T. hemsleyanum were comparatively analyzed. RE-SULTS:Compared with no slicing,sliced T. hemsleyanum can shorten the drying time and reduce the loss of active ingredients. In the 5 drying methods,freeze drying was the best for keeping the active ingredients in T. hemsleyanum. After drying,the contents of total flavonoids,polysaccharides,total polyphenols and β-sitosterol were 18.5 mg/g,92.7 mg/g,9.19 mg/g and 0.344 mg/g respec-tively,followed by microwave drying,hot-air drying,drying in the shade and drying in the sunlight. The contents of active ingredi-ents had statistical significance by each drying methods (P<0.05 or P<0.01). CONCLUSIONS:Different drying technologies have obvious effects on the quality of T. hemsleyanum. Slicing and hot-air drying at 60 ℃ were suggested as suitable method for T. hemsleyanum in terms of cost,content of active ingredients and practicability.

RESUMEN

Aim To observe the effect of agiophyllum oligo saccharides ( AOS) on reducing blood sugar, im-proving insulin resistance on diadetic Goto-Kakizaki ( GK) rats, and to explore the possible mechanism. Methods The type 2 diabetes GK rats were divided into six groups: model control group ( MC ) , Glenn benzene urea group ( GLB ) , high agriophyllum squar-rosum coarse oligosaccharides ( AOS-H ) , medium ( AOS-M ) , low dose group ( AOS-L ) , homologous Wistar rats as normal control ( NC ) . All animals were administered with AOS by oral gavage, for 8 weeks. The fasting blood glucose ( FBG) , random blood sugar ( RBG) , glucose tolerance ( OGTT) were tested before and after administration. No fasting sugar load status before and after dosing changes in blood glucose and serum insulin level in rats were measured in the previ-ous 8 weeks. At the end of administration, the fasting serum glucose ( FPG) , insulin ( FINS) , OGTT and in-sulin resistance index ( HOMA IR) in fasting rats were analyzed. Lastly, the pathological changing of pancreas was observed by HE staining. Results The blood glucose of fasting GK rats was not influenced after using AOS. However, the random blood glucose significantly reduced, the glucose tolerance was improved and AUC was obviously reduced (P < 0. 01) after using AOS. The best effect was on AOS-M group, which was similar with Glenn benzene urea. Through our research, we found AOS could promote release of insulin. This best effect was on AOS-M and AOS-L groups, and the time and quantity of release were better than Glenn benzene urea. Finally, AOS inhibited the pathological changes of islet tissue on GK rats, increased the quantity of pancreas and islet cells. Compared with model group, the changing of islet structure was significantly reduced in AOS group. Conclusion AOS could obviously improve insulin resistance and lower blood sugar, and the mechanism of this effect may be related with rapidly promoting insulin release, increasing the islet cell proliferation,and improving the function of islet.

RESUMEN

Animals in captivity and in the wild face numerous challenges, including the risk of enduring acute or chronic stress. In captivity, facilities attempt to alleviate the risk of chronic stress by providing environmental enrichment, shown to minimize behavioral disorders and stress in several species. One potential form of enrichment in zoos is training animals to provide rides for guests, however, the effect of this activity on the welfare of individual animals has never been examined. We validated the use of saliva for assessing stress in dromedary camels (Camelus dromedarius), an animal commonly used for rides. We then measured variation in salivary cortisol in four male camels while providing rides of differing frequency for guests at the Toronto Zoo. The camels were sampled during the ride season (June to September) using four treatments: (1) in their pasture, (2) at the ride area when not performing rides, (3) while providing a low number of rides (n=50/day) and (4) while providing a high number of rides (n=150/day). Furthermore, samples were taken before and after the ride season for comparison. There was a significant difference between the post-ride season treatment and the three treatments involving guest presence during the ride season (ride area, low rides, high rides). In general, cortisol concentrations were lower during the ride season and higher during the non-ride season. Based on the metrics we used, performing rides is not a stressful experience for these dromedary camels and suggests that rides may be a form of enrichment.

Asunto(s)

RESUMEN

Objective To investigate effects of antioxidant stress protein hem e oxygenase-1 (HO-1) on lipopolysaccharide (LPS)-induced endoplasm ic reticulum stress (ERS) of rat hepatocytes. Methods The BRL cells (rat hepatocyte cell line) were cultured. The hepatocytes were treated with LPS, LPS+HO-1 si RNA , HO-1 siRNA and PB S solution, respectively. The cell viability was m easured by trypan blue ex-clusion test. The apoptosis cells were detected by the fluorescent dye Hoechst 33258. E xpressions of GR P78, C HO P, caspase-12 and HO-1 were detected by Western blotting. Results LPS caused an in-crease of HO-1 protein expression of rat hepatocytes in a dose-dependent and tim e-dependent m anner, a up-regulation of GRP78, CHO P and caspase-12, a decrease in cellviability,and an increase in apopto-sis rate of hepatocytes. Pretreatm ent of HO-1 siRNA inhibited the up-regulation of LPS-induced HO-1, however, aggravated ERS and cellular injury. Conclusion HO-1 inhibites ERS-m ediated cellular injury of rat hepatocytes induced by LPS.

RESUMEN

Presentamos el caso de una paciente de 30 años de edad previamente saludable, quien desarrolló luego de numerosos viajes en una montaña rusa un hematoma subdural espontáneo y un higroma contralateral. La estroma velocidad y despliegue de fuerza G, la sucesión de momentos de aceleración y desaceleración, los bruscos movimientos cefálicos con tironeo lateral del cerebro y el número de veces que permitió el viaje, constituyeron un riesgo significativo de ruptura de venas puente, siendo posible que las reiteradas caídas de una boya remolcada hayan constituido el último trauma y desencadenamiento final

We present the case of a 30-year-old previously healthy patient, who developed ofter numerous trips on a roller coaster a spontaneous hematoma subdural and a contralateral hygroma. Extreme speed and G-force deployment, the succession of moments of acceleration and deceleration, sudden cephalic movements with snarling side of the brain and the number of times that he repeated the trip, they constituted a significant risk of rupture of veins bridge, being possible that repeated falls from a towed buoy have produced the latest trauma and final trigger

Asunto(s)

RESUMEN

This study investigates pediatric injuries involving amusement rides treated in US emergency departments by retrospectively analyzing data from the National Electronic Injury Surveillance System. From 1990 to 2010, an estimated 92 885 children ≤17 years sought treatment in US hospital emergency departments for injuries involving amusement rides, yielding an annual average of 4423 injuries. The average annual injury rate was 6.24 injuries per 100 000 US children, and the mean patient age was 8.73 years. The head and neck was the most commonly injured body region (28.0%), and the most common type of injury was a soft tissue injury (29.4%). Falling in, on, off, or against the ride was the most frequent mechanism of injury (31.7%). Only 1.5% of injuries resulted in hospitalization. An improved national system for monitoring injuries involving amusement rides is needed. There are opportunities to improve the safety of amusement rides for children, especially to prevent injuries from falls.

Asunto(s)

RESUMEN

The glycosaminoglycan (GAG), isolated from Bay scallop Argopectenirradians, contains neutral monosaccharides besides hexosamines and hexosuronic acids. The monosaccharides obtained by alcoholysis with HCI-methylalcohol from the sample of GAG was trimethylsilanized with hexamethyldisilan and chlortrimethylsilan (HMDS ' TMCS = 2 : 1). And the trimethylsilyl derivatives of monosaccharides was determined by gas chro-matography. Compared the gas chromatography of the sample with that of standard monosaccharides, it was found that the GAG of the Bay scallop contains five neutral monosaccharides, viz glucose, galactose, xylose, fucose and rhamnose.