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BACKGROUND: Pneumococcal carriage has often been studied from a serotype perspective; however, little is known about the strain-specific carriage and inter-strain interactions. Here, we examined the strain-level carriage and co-colonization dynamics of Streptococcus pneumoniae in a Swiss birth cohort by PacBio single-molecule real-time (SMRT) sequencing of the plyNCR marker. METHODS: A total of 872 nasal swab (NS) samples were included from 47 healthy infants during the first year of life. Pneumococcal carriage was determined based on the quantitative real-time polymerase chain reaction (qPCR) targeting the lytA gene. The plyNCR marker was amplified from 214 samples having lytA-based carriage for pneumococcal strain resolution. Amplicons were sequenced using SMRT technology, and sequences were analyzed with the DADA2 pipeline. In addition, pneumococcal serotypes were determined using conventional, multiplex PCR (cPCR). RESULTS: PCR-based plyNCR amplification demonstrated a 94.2% sensitivity and 100% specificity for Streptococcus pneumoniae if compared to lytA qPCR. The overall carriage prevalence was 63.8%, and pneumococcal co-colonization (≥ 2 plyNCR amplicon sequence variants (ASVs)) was detected in 38/213 (17.8%) sequenced samples with the relative proportion of the least abundant strain(s) ranging from 1.1 to 48.8% (median, 17.2%; IQR, 5.8-33.4%). The median age to first acquisition was 147 days, and having ≥ 2 siblings increased the risk of acquisition. CONCLUSION: The plyNCR amplicon sequencing is species-specific and enables pneumococcal strain resolution. We therefore recommend its application for longitudinal strain-level carriage studies of Streptococcus pneumoniae. Video Abstract.

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The purpose of this study was to describe the changes in iron status indicators at 6 and 12 months of age, controlling by inflammation by measuring alpha-1 acid glycoprotein (AGP). This longitudinal study included 48 healthy-term singleton infants with birth weight ≥ 2500 g, born in hospitals of the Mexican Institute for Social Security. Complete blood count, ferritin, soluble transferrin receptor (sTfR), hepcidin, and AGP were measured in blood at 6 and 12 months of age. sTfR/ferritin ratio and total body iron (TBI) stores were calculated. Hemoglobin and sTfR/ferritin ratio increased with age, while ferritin and TBI decreased. In infants without inflammation, hepcidin, sTfR, and MVC did not show significant changes from 6 to 12 months of age, while ferritin and TBI decreased. In infants with inflammation, hepcidin, TBI, and ferritin levels increased, while hemoglobin and sTfR/ferritin ratio decreased. MVC and sTfR did not change significantly in the presence or absence of inflammation. Hepcidin concentration correlated positively and significantly with ferritin and TBI stores and showed significant negative correlation with sTfR/ferritin ratio. Our study showed that, in absence of inflammation and ID, during the first year of life, physiological changes occur in hemoglobin and ferritin levels as well as in indicators derived from ferritin and sTfR; in contrast, hepcidin and sTfR did not show significant change. However, hepcidin concentration was lower in infants with ID and was higher when inflammation was present, supporting that infants have a functional hepcidin response to changes in iron stores.

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OBJECTIVE: To report a rare case of Down's syndrome with congenital acute leukemia and congenital heart disease. MATERIAL AND METHODS: We have retrospectively analyzed an electronic database of patients aged 0-17 years who underwent inpatient treatment of congenital heart disease at the Federal Center for Cardiovascular Surgery for the period from January 1, 2010 to December 31, 2018. Incidence of Down's syndrome in children with congenital heart defects was 5.36% of the total number of children with congenital heart defects. No gender differences were identified. The most common congenital heart defects were ventricular septal defect, atrioventricular septal defect, atrial septal defect, patent ductus arteriosus, tetralogy of Fallot. Down's syndrome and congenital heart disease were diagnosed prenatally in 33 out of 319 patients. A rare case of Down's syndrome combined with congenital heart disease and acute leukemia is described. Treatment outcome was unfavorable. CONCLUSION. S: Evere concomitant diseases in a child with Down's syndrome determine high postoperative morbidity and mortality. Prenatal diagnosis of Down's syndrome via screening of pregnant women for ultrasound and biochemical markers of this pathology is required.

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In this study, we analyzed whether 6-month gross and fine motor skills were related to 12-month gross and fine motor skills and cognitive development, controlling for 6-month cognitive skills, and neonatal status (extremely low gestational age ELGA ≤ 28 weeks vs. full-term FT ≥ 37 weeks). We also investigated, at 6 months, predictive indexes for motor and cognitive delay at 12-months. We assessed 40 infants (20 ELGA and 20 FT) at 6 and 12 months (corrected age for the ELGA infants). Six-month gross motor skills were related to 12-month gross motor, fine motor, and cognitive skills and predicted 12-month gross motor delay. Six-month cognitive skills explained an additional amount of variance of 12-month gross motor skills, whereas neonatal status explained an additional amount of variance of 12-month cognitive skills. Considering the intradomain and cross-domain cascading effects of early gross motor skills on later motor and cognitive development, these skills should be repeatedly assessed in ELGA infants in the first year of life for early identification of infants with delayed gross motor skills and implementation of customized interventions.

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BACKGROUND/OBJECTIVES: The establishment of newborn skin flora depends on the ongoing skin maturation and the existence of potential microbial colonizers within the environment of the infant during a period of intense mother-infant physical interaction. This longitudinal study assessed culturable skin bacteria in the mother-infant dyad during the first year of life. METHODS: A total of 17 mother-infant dyads were swabbed within 24 hours postpartum and at 3, 6, 9, and 12 months. Skin swabbing was performed on two anatomical areas per individual (mothers: chest-abdomen; infants: forehead-buttocks) and were incubated in five different solid culture media to optimize yield. Isolated bacterial species were identified to genus or species level using the API system (BioMeriéux, Marcy l'Etoile, France). RESULTS: A total of 444 microbial strains were isolated belonging to 22 genera: 6 "frequent" (isolated from > 5% samples: S aureus, Proteus, Klebsiella, Pseudomonas, Enterobacter, and Enterococcus) and 16 "infrequent." Isolated genera per individual peaked at 6 months postpartum for mothers and infants (P < 0.05). Enterobacter, Enterococcus, Klebsiella, and Pseudomonas isolation rates varied significantly as a function of sampling time contrary to the rather constant isolation rates of Proteus and S aureus. The rates of concordant isolation of the same microbial species within the mother-infant dyad tended to drop from birth to the end of the first year postpartum. CONCLUSIONS: Distinct variations in the isolation rates of skin commensals from specific anatomical sites of the mother-infant dyad indicate bidirectional microbial transmission. Increasing skin flora individuality of the growing infant was recorded, manifested by declining rates of concordant isolation of the same microbial species from mother and her infant.

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BACKGROUND & AIMS: We performed a population-based study to determine whether there was an increased risk of inflammatory bowel diseases (IBD) in persons with critical events at birth and within 1 year of age. METHODS: We collected data from the University of Manitoba IBD Epidemiology Database, which contains records on all Manitobans diagnosed with IBD from 1984 through 2010 and matched controls. From 1970 individuals' records can be linked with those of their mothers, so we were able to identify siblings. All health care visits or hospitalizations during the neonatal and postnatal periods were available from 1970 through 2010. We collected data on infections, gastrointestinal illnesses, failure to thrive, and hospital readmission in the first year of life and sociodemographic factors at birth. From 1979, data were available on gestational age, Apgar score, neonatal admission to the intensive care unit, and birth weight. We compared incident rate of infections, gastrointestinal illnesses, and failure to thrive between IBD cases and matched controls as well as between IBD cases and siblings. RESULTS: Data on 825 IBD cases and 5999 matched controls were available from 1979. Maternal diagnosis of IBD was the greatest risk factor for IBD in offspring (odds ratio [OR], 4.53; 95% confidence interval [CI], 3.08-6.67). When we assessed neonatal events, only being in the highest vs lowest socioeconomic quintile increased risk for later development of IBD (OR, 1.35; 95% CI, 1.01-1.79). For events within the first year of life, being in the highest socioeconomic quintile at birth and infections (OR, 1.39; 95% CI, 1.09-1.79) increased risk for developing IBD at any age. Infection in the first year of life was associated with diagnosis of IBD before age 10 years (OR, 3.06; 95% CI, 1.07-8.78) and before age 20 years (OR, 1.63; 95% CI, 1.18-2.24). Risk for IBD was not affected by gastrointestinal infections, gastrointestinal disease, or abdominal pain in the first year of life. CONCLUSIONS: In a population-based study, we found infection within the first year of life to be associated with a diagnosis of IBD. This might be due to use of antibiotics or a physiologic defect at a critical age for gut microbiome development.

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Introducción: La lactancia materna es recomendada como fuente de alimentación optima para los primeros meses de vida. En nuestro Servicio hemos recibido un grupo particular de niños alimentados con lactancia materna exclusiva, que muestran aumento excesivo de peso desde el primer semestre de vida. Objetivo: describir las características clínicas de un grupo de lactantes menores de un año, con aumento excesivo de peso y alimentación con lactancia materna. Población y métodos: estudio observacional, prospectivo y longitudinal. Incluimos todos los niños menores de un año derivados al servicio de Nutrición entre 2003 y 2015, con lactancia materna exclusiva durante los primeros 6 meses, persistencia de la misma al momento de la evaluación y peso- edad mayor a 2 desvíos estándar (DS). Describimos características clínicas y de laboratorio de los lactantes y sus madres, así como el patrón alimentario que pudiera explicar esta inusual ganancia de peso. Resultados: incluimos 73 lactantes, 63% niñas. El 64% tenía peso-talla mayor a 2DS a los 3 meses de vida y el 100% a los 6 meses. No se pudo establecer patrón hambresaciedad. El 44% de las madres aumentó más de 18 kilogramos durante el embarazo. Las niñas nacidas de las madres que habían aumentado más de 18 Kg fueron significativamente más grandes al nacer. En el 14% de los lactantes se encontró alguna enfermedad de base. De toda la muestra, el 75% presentó anemia y el 14.5% hipotiroidismo. Conclusiones: describimos un grupo de lactantes con aumento excesivo de peso desde los primeros 3 meses de vida que se mantiene durante toda la etapa de lactancia materna. Diferentes factores como relación madre-hijo, patrón alimentario, composición de la leche humana, predisposición genética; podrían haber contribuido con este patrón de crecimiento.(AU)

Introduction: Maternal breastfeeding is recommended as the best source of nutrition in the first months of life. At our Department we have seen a group of exclusively breastfed children who showed excessive weight since the first semester of life. Objective: To describe the clinical features of a group of infants under one year of age with excessive weight gain while being breast-fed. Population and methods: A prospective, longitudinal, observational study was conducted. We included all infants under one year of age who were referred to the Department of Nutrition between 2003 and 2015, who were exclusively breastfed during the first 6 months of life and were still being breastfed at the moment of the evaluation, and who had a weight-for-age of more than 2 standard deviation (SD). We describe the clinical and laboratory features of the infants and their mothers, as well as feeding patterns that may explain this unusual weight gain. Results: We included 73 infants, 63% girls. Overall, 64% had a weight-for-height greater than 2 SD at 3 months of life and 100% at 6 months of life. No hunger-satiety pattern could be established. Of the mothers, 44% gained more than 18 kg during the pregnancy. The girls born from mothers who had increased more than 18 Kg were significantly larger at birth. In 14% of the infants, an underlying disease was found. Of all the infants in the sample, 75% had anemia and 14.5% hypothyroidism. Conclusions: We describe a group of infants with excessive weight gain in the first 3 months of life which was maintained throughout the maternal breastfeeding period. Different factors, such as the motherchild relationship, feeding pattern, human milk composition, and genetic predisposition may have contributed to this particular growth pattern. (AU)

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O texto visa delinear algumas questões e princípios para uma fenomenologia do infans enquanto é pré-falante, fase que inclui a vida intrauterina do feto e do bebê no primeiro ano de vida antes da aquisição da fala. O corpo é visto como fonte da materialidade vivida de sentido em vários níveis onde a relação de sentido com mundo é desdobrada. A apropriação de sentido começa remotamente na primeira síntese integradora que caracteriza a passagem do embrião á vida fetal com a formação do sistema nervoso central e dos sentidos corpóreos. A origem da formação do m=undo horizonte de sentidos, acontece antes do nascimento e os trabalhos da ciência e da fenomenologia ganham ambas nesse diálogo.

The text aims to delineate some questions and principles for a phenomenology of the infans as a pre-speaker child, a phase that includes the intrauterine life of the fetus and the newborn in the first year of life before speech acquisition. The body is seen as the source of living materiality of meaning on several levels and where the relation of meaning to the world is unfolded. The appropriation of meaning begins remotely in the first integrative synthesis that characterizes the passage from the embryo to the fetal life through the formation of the central nervous system and the bodily senses. The origin and the formation of the world horizon of meanings has it locus before birth; works of biosciences and phenomenology are put together in dialogue.

El texto pretende esbozar algunas cuestiones y principios para una fenomenología del infans en tanto que pre-hablante, fase que incluye la vida intrauterina del feto y el bebé durante el primer año de vida antes de la adquisición del habla. El cuerpo es visto como una fuente de materialidad viviente de sentido en muchos niveles donde se despliega el sentido de la relación con el mundo. La apropiación del sentido comienza remotamente en la primera síntesis integradora que caracteriza el paso del embrión a la vida fetal con la formación del sistema nervioso central y los sentidos corporales. El origen de la formación del horizonte mundo de sentido ocurre antes del nacimiento; en eso los trabajos de la biocientíficos y la fenomenología pueden dialogar.

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Although early object exploration is considered a key ability for subsequent achievements, very few studies have analyzed its development in extremely low gestational age infants (ELGA- GA <28 weeks), whose early motor skills are delayed. Moreover, no studies have examined its developmental relationship with cognitive and language skills. The present study examined developmental change in Motor Object Exploration (MOE) and different types of MOE (Holding, Oral, Manual and Manual Rhythmic Exploration) in 20 ELGA and 20 full term (FT) infants observed during mother-infant play interaction at 6 and 9 months. It also explored whether specific types of MOE were longitudinally related to 24-month language and cognitive abilities (GMDS-R scores). ELGA infants increased MOE duration from 6 to 9 months, eliminating the initial difference with FT infants. In addition, ELGA infants showed a different pattern of Oral Exploration, that did not increase at 6 months and decrease at 9 months. Oral and Manual Exploration durations at 6 months were longitudinally related to 24-month GMDS-R language and cognitive performance scores respectively. We discuss the relevance of assessing early exploratory abilities in ELGA infants in order to implement customized intervention programs for supporting the development of these skills.

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BACKGROUND: Breastfeeding is recommended as the best source of nutrition in the first months of life and observational studies have associated exclusive breastfeeding with decreased weight gain and a protective effect against obesity in childhood. The objective of this study was to describe the characteristics of a cohort of exclusively breastfed obese infants to determine factors that may lead to this unusual weight gain. METHODS: Infants seen between 2003 and 2015 who were exclusively breastfed and showed excessive weight gain in the first year of life were followed with a focus on features of the mother, the child, feeding patterns and the presence of concomitant factors that influence nutritional status. Additionally, in a subset of the sample, macronutrients of the maternal breast milk were analyzed. A descriptive, prospective cross-sectional study was conducted. RESULTS: Of 73 patients, 63% were girls. At 3 months of life, 64% had a weight-for-height standard deviation score (SDS) >2. At 6 and at 12 months, 100% of the patients had a weight-for-height >2 SDS. The mean age at semisolid-food introduction was 7 months. The mean age at weaning was 15.8 months. The babies were fed on demand and no hunger-satiety pattern was observed. In the breast milk samples analyzed, a significantly lower fat content was found. CONCLUSIONS: The results of our study lead to the assumption that inter-individual variations in mother's milk composition may affect the growth patterns of children.

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El propósito de este artículo es presentar un balance bibliográfico del estudio de las relaciones afectivas en el primer año de vida a partir del análisis cualitativo de artículos teóricos e investigativos publicados durante las cuatro últimas décadas. La selección de artículos adopta como criterio el índice de citación que denota relevancia y amplia circulación de los postulados teóricos-metodológicos en este campo de conocimiento. Las reseñas de los artículos se sistematizan en una rejilla descriptiva que permite identificar los elementos constitutivos de una publicación y la consistencia interna de la conceptualización. Las reseñas de los artículos investigativos incluyen la revisión del diseño, las técnicas de recolección de información y las unidades analíticas que utilizan los investigadores. El análisis cualitativo de las reseñas sistematizadas establece algunas polaridades que estructuran las publicaciones: innato - adquirido; endógeno - exógeno; desarrollo de dominio general - desarrollo de dominio específico; cambios macro - cambios micro. En términos metodológicos, diseños experimentales - diseños situacionales en contextos culturales específicos; modelos de análisis de relaciones causales directas - modelos de análisis de relaciones múltiples. Simultáneamente, estas polaridades definen cuatro perspectivas que sintetizan las afinidades teóricas y metodológicas de las publicaciones: innatistas, ecológico-contextual, interaccionista y de los Sistemas Dinámicos No Lineales (SDNL). En la discusión presentamos la matriz de pensamiento psicológico y las concepciones de desarrollo que están implícitas en cada una de las perspectivas. Por último, en las conclusiones destacamos la búsqueda de algunos investigadores por modelos de análisis que establezcan diálogos de fronteras entre perspectivas para superar las polaridades con el propósito de comprender la complejidad de las relaciones afectivas en el primer año de vida. En este esfuerzo surgen los estudios de los SDNL para explicar la emergencia de la novedad en el desarrollo afectivo-cognitivo del niño a partir de los eventos de reorganización en el interior de los sistemas diádicos.

The aim of this article is to present a bibliographic review of the study of affective relationships in the first year of life based on qualitative analysis of theoretical and investigative articles published during the last four decades. The articles' selection adopts as a criterion the index of citation that denotesrelevance and wide circulation of the theoretical and methodological postulates in this field of knowledge. The reviews of the articles are systematized in a descriptive grid that allows to identify the constituent elements of a publication and the internal consistency of the conceptualization. Reviews of investigative articles include the design review, data collection techniques, and analytical units used by researchers. The qualitative analysis of systematized reviews, establishes some polarities that structure publications: innate - acquired; Endogenous - exogenous; General domain development - specific domain development; Macro changes - micro changes. In methodological terms, experimental designs - situational designs in specific cultural contexts; direct causal relationship analysis models - multiple relationship analysis models. Simultaneously, these polarities define four perspectives that synthesize the theoretical and methodological affinities of the publications: innatist, ecological-contextual, interactionist and Nonlinear Dynamic Systems (SDNL). In the discussion, we present the matrix of psychological thinking and the conceptions of development that are implicit in each one of the perspectives. Finally, in the conclusions we highlight the researchers' search for models of analysis that establish border dialogues between perspectives to overcome the polarities to understand the complexity of affective relationships in the first year of life. In this effort arise the studies of SDNL to explain the emergence of novelty in the affective-cognitive development of the child from the events of reorganization within the dyadic systems.

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BACKGROUND: Evidence linking long-term exposure to outdoor air pollution with allergic rhinitis (AR) in children is scare, and the role of components of air pollution and timing of exposure remains unclear. OBJECTIVE: To assess the association of pre- and post-natal exposure to air pollution with life-time prevalence of AR in preschool children. METHODS: We conducted a cohort study of 2598 children aged 3-6 years in Changsha, China. The lifetime prevalence of AR was assessed by a questionnaire administered by parents. Children's exposures to dioxide nitrogen (NO2), sulfur dioxide (SO2) and particulate matter with an aerodynamic diameter ≤ 10 µm (PM10) during different pre- and post-natal timing windows were estimated using the measured concentrations at monitoring stations. The odds ratio (OR) and 95% confidence interval (CI) of childhood AR for exposure to different air pollutants during different timing windows were assessed by logistic regression model in terms of an interquartile range (IQR) increase in exposure level. RESULTS: Life-time prevalence of AR in preschool children (7.3%) was associated with both pre- and post-natal exposure to traffic-related air pollution (TRAP), but only significant during the third trimester of pregnancy with adjusted OR = 1.40 (95% CI: 1.08-1.82) for a 15 µg/m3 increase in NO2 and during the first-year of life with adjusted OR = 1.36 (95% CI: 1.03-1.78) and 1.54 (95% CI: 1.07-2.21) respectively for 11 and 12 µg/m3 increase in NO2 and PM10. The association of early life exposure to TRAP with childhood AR was robust by adjusting for other air pollutants and timing windows. Sensitivity analysis indicated that the association was higher in the children who are male, young, with genetic predisposition by parental atopy, and living in damp houses. CONCLUSION: Early life exposure to traffic-related air pollutant during pregnancy and first-year of life may contribute to childhood AR.

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UNLABELLED: Little is known about the dietary patterns of Asian infants in the first year of life, nor of their associations with maternal socio-demographic factors. Based on the Growing Up in Singapore towards healthy Outcomes (GUSTO) mother-offspring cohort, cross-sectional dietary patterns were derived by factor analysis using 24-h recalls and food diaries of infants at 6-, 9- and 12-months of age. Dietary pattern trajectories were modeled by mapping similar dietary patterns across each age using multilevel mixed models. Associations with maternal socio-demographic variables, collected through questionnaires during pregnancy, were assessed using general linear models. In n = 486 infants, four dietary pattern trajectories were established from 6- to 12-months. Predominantly breastmilk: mainly breastmilk and less formula milk, GUIDELINES: rice porridge, vegetables, fruits and low-fat fish and meat, Easy-to-prepare foods: infant cereals, juices, cakes and biscuits and Noodles (in soup) and seafood: noodle and common accompaniments. In adjusted models, higher maternal education attainment was correlated with higher start scores on Predominantly breastmilk, but lowest education attainment increased its adherence over time. Older mothers had higher start scores on Easy-to-prepare foods, but younger mothers had increased adherence over time. Chinese mothers had higher start scores on Predominantly breastmilk but greater adherence to GUIDELINES over time, while Indian mothers had higher start scores on Easy-to-prepare foods but greater adherence to Predominantly breastmilk with time (p < 0.05 for all). Changes in trajectories over time were small. Hence, dietary patterns established during weaning are strongly influenced by maternal socio-demographic factors and remain stable over the first year of life.

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BACKGROUND: The longitudinal pattern of allergen-specific IgE levels from the prenatal stage to early life has remained largely unexplored. METHODS: One-hundred and three mother-infant pairs, which were part of an ongoing population-based prospective birth cohort study of early childhood allergic diseases in Tainan, Taiwan, were included in this study. We examined the relationship of 20 allergen-specific IgE levels with blood samples of mothers, cord blood, and infants at 12 months of age using Spearman rank correlation, Kenal τ and McNemar test, respectively. RESULTS: Certain degree of IgE sensitization against most 20 examined specific allergens was observed in blood samples of mothers, cord blood, and infants at 12 months of age. When we further examined the association between allergy-related risk factors and atopy in infants at the first year of life, we found positive association between colic pain and atopy in infants at 12 months of age [adjusted odds ratios (AOR) = 3.51; 95% confidence interval (CI): 1.13-10.96; p = 0.03], and borderline significance between wheezing and atopy in infants at 12 months of age (AOR = 4.58; 95% CI: 0.89-23.50; p = 0.07). CONCLUSION: The findings from this study suggest that influence of maternal allergen-specific IgE levels on infant immune response might occur at birth and then wane in infants at 12 months of age. Positive association of colic pain and wheezing with atopy in infants at 12 months of age provides supportive evidence for the 'Allergy March' theory of allergy development in an Asian birth cohort.

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This study evaluated the normal number of inflammatory cells in the heart in the first year of life using two methods to compare their ability to quantitate physiological myocardial infiltration. Eight endomyocardial samples from both ventricles were obtained at autopsy from 56 structurally normal hearts during the first year of life. In each sample the numbers of leucocytes, T-lymphocytes and macrophages were counted once in 20 randomly chosen high-power fields (400×) as well as in a 10mm(2) area of randomly chosen myocardial tissue (100×) by two independent investigators. Compared to the literature a greater representative proportion of myocardial tissue was analyzed. The results of the enumeration in mm(2) were converted into high-power-fields to compare both methods. The mean numbers and standard deviations for leucocytes, T-lymphocytes and macrophages were calculated. Both counting methods showed similar results with low inflammatory cell counts per single heart and staining. A greater understanding of the physiological myocardial infiltration by leucocytes, T-lymphocytes and macrophages is important for postmortem forensic cases, and for the interpretation of endomyocardial biopsies in infants.

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La relación entre el cuidado materno (sensibilidad) y la seguridad del apego del niño (conducta de base segura) ha sido corroborada en diferentes contextos y edades. Sin embargo, existe ausencia de estudios que la hayan estudiado antes del primer año de vida. La presente investigación analizó esta relación en un grupo de 32 madres peruanas de 19 a 44 años de nivel socioeconómico bajo y sus hijos de 8 a 10 meses. La sensibilidad fue evaluada a través del Q-sort del Comportamiento Materno (MBQS) (Pederson & Moran, 1995) y la seguridad del apego mediante el Q-sort del Apego (Waters, 1995). Los resultados muestran que existe una relación directa y significativa entre ambas y que las separaciones físicas juegan un rol importante en esta relación.

Sensitivity hypothesis has been corroborated in different contexts and children ages; however, there is lack of studies that have analyzed it in the first year of life. The present study related maternal sensitivity and child secure base behavior in a group of 32 Peruvian mothers of low income families. Mothers were 19 to 44 years old and their children were between 8 and 10 months old. Mother's sensitivity was assessed using the Q-sort Maternal Behavior (Pederson & Moran, 1995) and child secure base behavior through the Attachment Q-sort (Waters, 1995). Results indicated a significant and direct relationship between two constructs and that early mother-infant physical separations play an important role in this relationship.

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BACKGROUND: Early life is suggested to be a critical time in determining subsequent asthma development, but the extent to which the effect of early-life exposure to ambient air pollution on childhood asthma is unclear. OBJECTIVES: We investigated doctor-diagnosed asthma in preschool children due to exposure to ambient air pollution in utero and during the first year of life. METHODS: In total 2490 children aged 3-6 years participated in a questionnaire study regarding doctor-diagnosed asthma between September 2011 and January 2012 in China. Children's exposure to critical air pollutants, sulfur dioxide (SO2) as proxy of industrial air pollution, nitrogen dioxide (NO2) as proxy of traffic pollution, and particulate matter≤10µm in diameter (PM10) as a mixture, was estimated from the concentrations measured at the ambient air quality monitoring stations by using an inverse distance weighted (IDW) method. Logistic regression analysis was employed to determine the relationship between early-life exposure and childhood asthma in terms of odds ratio (OR) and 95% confidence interval (CI). RESULTS: Association between early-life exposure to air pollutants and childhood asthma was observed. SO2 and NO2 had significant associations with adjusted OR (95% CI) of 1.45 (1.02-2.07) and 1.74 (1.15-2.62) in utero and 1.62 (1.01-2.60) and 1.90 (1.20-3.00) during the first year for per 50 µg/m(3) and 15 µg/m(3) increase respectively. Exposure to the combined high level of SO2 and NO2 in China significantly elevated the asthmatic risk with adjusted OR (95% CI) of 1.76 (1.18-2.64) in utero and 1.85 (1.22-2.79) during the first year compared to the low level exposure. The associations were higher for males and the younger children aged 3-4 than females and the older children aged 5-6. CONCLUSIONS: Early-life exposure to ambient air pollution is associated with childhood asthma during which the level and source of air pollution play important roles. The high level and nature of combined industrial and traffic air pollution in China may contribute to the recent rapid increase of childhood asthma.

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INTRODUCTION: The strategies used by parents in education and childcare play a major role in the child's development and health OBJECTIVE: To describe and analyse the maternal educational practices during the first year of life METHODS: A total of 250 mothers of infants between 1-12 months participated in the study. The data was collected using the Parental Styles Inventory for Mothers of Babies (IEPMB RESULTS: Mothers used the positive parenting practice: Monitoring Positive. However negative practices were also present in the repertoire of the participants, especially Relaxed Discipline CONCLUSION: The negative practices were not common in the behavioural repertoire of the mothers, so this phase is an appropriate stage to promote preventative interventions aimed at improving the mother-infant relationship, and therefore impacting health prevention, health promotion and child development.(AU)

As estratégias utilizadas pelos pais na educação e cuidados dos filhos possuem uma função primordial no desenvolvimento e saúde infantil. A presente pesquisa pretendeu descrever e analisar as práticas educativas maternas no primeiro ano de vida. Participaram da pesquisa 250 mães com filhos no primeiro ano de vida, de um a 12 meses de idade, nas quais foi aplicado o Inventário de Estilos Parentais para Mães de Bebês. Os resultados revelaram que as mães utilizam-se com frequência da prática parental positiva Monitoria Positiva, no entanto as práticas negativas, também são presentes no repertório das participantes, principalmente a prática Disciplina Relaxada. Como a maioria das práticas negativas ainda não são freqüentes no repertório comportamental das mães, esta fase seria portanto, um ótimo momento para a realização de intervenções preventivas que visem aprimorar o relacionamento mãe-criança, e consequentemente atuar na prevenção e promoção da saúde e do desenvolvimento.(AU)

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The strategies used by parents in education and childcare play a major role in the child's development and health OBJECTIVE: To describe and analyse the maternal educational practices during the first year of life METHODS: A total of 250 mothers of infants between 1-12 months participated in the study. The data was collected using the Parental Styles Inventory for Mothers of Babies (IEPMB RESULTS: Mothers used the positive parenting practice: Monitoring Positive. However negative practices were also present in the repertoire of the participants, especially Relaxed Discipline CONCLUSION: The negative practices were not common in the behavioural repertoire of the mothers, so this phase is an appropriate stage to promote preventative interventions aimed at improving the mother-infant relationship, and therefore impacting health prevention, health promotion and child development...

As estratégias utilizadas pelos pais na educação e cuidados dos filhos possuem uma função primordial no desenvolvimento e saúde infantil. A presente pesquisa pretendeu descrever e analisar as práticas educativas maternas no primeiro ano de vida. Participaram da pesquisa 250 mães com filhos no primeiro ano de vida, de um a 12 meses de idade, nas quais foi aplicado o Inventário de Estilos Parentais para Mães de Bebês. Os resultados revelaram que as mães utilizam-se com frequência da prática parental positiva Monitoria Positiva, no entanto as práticas negativas, também são presentes no repertório das participantes, principalmente a prática Disciplina Relaxada. Como a maioria das práticas negativas ainda não são freqüentes no repertório comportamental das mães, esta fase seria portanto, um ótimo momento para a realização de intervenções preventivas que visem aprimorar o relacionamento mãe-criança, e consequentemente atuar na prevenção e promoção da saúde e do desenvolvimento...

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INTRODUCTION: Feeding is of particular importance in the first year of life when weaning occurs gradually and competes with complementary feeding to meet the nutritional needs of a child in order to ensure growth and development. OBJECTIVE: To describe feeding practices in infants in the first year of life. METHODS: Cross-sectional study using a questionnaire about a child's eating habits. The sample consisted of 122 children aged up to 365 days, divided into two groups: group 1 consisted of 34 children up to 3 full months of age, and group 2 consisted of 88 children, 4-12 months old. RESULTS: Among the children in group 1, only 35.29% were exclusively breastfed, but 95.9% of the study population reported having been breastfed; and 55.68% of children in group 2 still take milk. In group 2, among the foods already introduced in the infants' feeding was: 83% fruit, 69% vegetables, meat broth 52.27%, 58% meat (beef and chicken), 76% bean broth, 42% beans, 59% rice /noodles, 78% potatoes, 22.72% egg yolk, 16% whole egg and 61% bread wafer. There was no reference to vegetables from 52.27% of the population, and 73.86% and 75% have not introduced fish or liver, respectively. CONCLUSION: The dietary habits of children who participated in the study include a great diversity of food, but there was a low proportion of exclusive breastfeeding as a result of the early introduction of complementary foods. A low consumption of foods such as vegetables and liver was observed...(AU)

INTRODUÇÃO: A alimentação é especialmente importante no primeiro ano de vida quando ocorre o desmame progressivo e compete à alimentação complementar suprir as necessidades nutricionais da criança a fim de garantir o crescimento e desenvolvimento. OBJETIVO: Descrever a prática alimentar em crianças no primeiro ano de vida. MÉTODO: Estudo transversal, com aplicação de questionário sobre a prática alimentar da criança. A amostra foi constituída de 122 crianças com idade até 365 dias divididas em 2 grupos: com até 3 meses completos de idade (34 crianças) e o grupo 2 foi formado por 88 crianças de 4 a 12 meses. RESULTADOS: Entre as crianças do grupo 1, apenas 35,29% estavam em aleitamento materno exclusivo porém 95,9% da população de estudo referiu ter sido amamentada e 55,68% das crianças do grupo 2 ainda tomam leite materno. Dentre os alimentos já introduzidos na alimentação das crianças do grupo 2, obteve-se: 83% para frutas, 69% legumes, 52,27% caldo de carnes, 58% de carnes (bovina e frango), 76% caldo de feijão, 42% feijão, 59% arroz/macarrão, 78% batata, 22,72% gema de ovo,16% ovo inteiro e 61% pão e bolacha. Verificou-se ausência de referência a verduras entre 52,27% da população, 73,86% não introduziram peixe e 75% o fígado. CONCLUSÃO: As práticas alimentares das crianças que participaram do estudo incluem grande diversidade de alimentos, porém houve baixa proporção de aleitamento materno exclusivo, em consequência da introdução precoce da alimentação complementar. Foi verificado baixo consumo de alguns alimentos como verduras e fígado...(AU)

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