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A panel of 2,3-disubstituted thiazolidin-4-ones 4a-n was synthesised from Schiff bases 3a-n derived from sulfanilamide, by reaction with thioglycolic acid. The compounds were characterised by means of IR, NMR, and Mass spectral data. Compounds 4a-n were screened for DPPH scavenging assay and compounds 4e, 4h, 4i, and 4n exhibited moderate activity. Compounds 4e, 4h, and 4i were tested at 200 mg/kg and 4e at 50 mg/kg b.w. orally for antidiabetic activity in fructose induced diabetic rats. They exhibited significant antidiabetic activity compared to the control group. Pioglitazone was used as a standard drug. The tested compounds exhibited better and ignificant serum cholesterol lowering activity when compared with the control and standard groups. They also reduced the triglyceride level after the 21st day; however, it was insignificant when compared to the control group. Compound 4n displayed the highest binding energy when docked with PPAR-γ followed by compounds 4e, 4h, and 4i when compared to pioglitazone. The physicochemical, drug likeness and ADME properties of the title compounds were found to be satisfactory.

Se sintetizó un panel de tiazolidinas-4-onas 2,3-disustituidas 4a-n a partir de las bases de Schiff 3a-n derivadas de la sulfanilamida por reacción con ácido tioglicólico. Los compuestos se caracterizaron por IR, RMN y datos espectrales de masa. Los compuestos 4a-n se analizaron para DPPH y los compuestos 4e, 4h, 4i y 4n mostraron una actividad moderada. Los compuestos 4e, 4h y 4i se probaron a 200 mg/kg y 4e a 50 mg/kg b.w. oralmente para la actividad antidiabética en ratas diabéticas, inducida por fructosa. Los compuestos mostraron una actividad antidiabética muy significativa en comparación con el grupo control. La pioglitazona se utilizó como fármaco estándar. Los compuestos ensayados mostraron una mejor y significativa actividad reductora del colesterol sérico en comparación con los grupos control y estándar. Estos compuestos también redujeron el nivel de triglicéridos después del 21° día, aunque fue insignificante en comparación con el grupo control. El compuesto 4n mostró la mayor afinidad de unión cuando se acopló a PPAR-γ, seguido de 4e, 4h y 4i en comparación con la pioglitazona. Las propiedades fisicoquímicas, la similitud con el fármaco y las propiedades ADME de los compuestos fueron satisfactorias, lo que los convierte en útiles agentes antidiabéticos.

Um painel de 2,3-disubstituído thiazolidina-4-ones 4a-n foram sintetizados a partir de bases Schiff 3a-n derivado da sulfanilamida por reacção com ácido tioglicólico. Os compostos eram caracterizado por IR, NMR e dados espectrais de massa. Os compostos 4a-n foram rastreados para O ensaio DPPH de limpeza radical e os compostos 4e, 4h, 4i e 4n exibiram actividade moderada. Os compostos 4e, 4h e 4i foram testados a 200 mg/kg e 4e a 50 mg/kg de peso corporal por via oral para antidiabéticos. actividade em ratos diabéticos induzidos por frutose. Exibiram uma actividade antidiabética altamente significativa actividade em comparação com o controlo. A pioglitazona foi utilizada como droga padrão. Os compostos testados exibiu uma melhor e significativa actividade de redução do colesterol sérico quando comparado comde triglicéridos após o 21° dia; no entanto, foi insignificante quando comparado com o controlo. O composto 4n mostrou a maior afinidade de ligação quando acoplado com PPAR-γ seguido de 4e, 4h, 4i quando comparado com pioglitazona. O propriedades físico-químicas, de semelhança com drogas e ADME dos compostos do título de propriedade também foram encontrados paraser satisfatórios, tornando-os agentes antidiabéticos úteis.

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RESUMEN Con el objetivo de describir el perfil lipídico por trimestres de gestación en gestantes sanas, se realizó un estudio descriptivo, de corte transversal, el cual se condujo con 40 embarazadas entre 20 y 35 años, de un universo de 110, pertenecientes al policlínico "Jimmy Hirzel" de Bayamo, Granma, entre enero del 2017 y marzo del 2019. Se determinaron las concentraciones de colesterol total, triglicéridos, HDL-colesterol, LDL-colesterol y VLDL-colesterol. Se utilizó el análisis de varianza de un factor, y la prueba de Tukey de comparación múltiple de parejas de medias. El colesterol, los triglicéridos, el LDL-colesterol y el VLDL-colesterol variaron de forma significativa con el trimestre de gestación. El colesterol total se incrementó en el segundo y tercer trimestre en comparación con el primero, mientras que los triglicéridos, el LDL-colesterol y el VLDL-colesterol se incrementaron en el tercer trimestre en comparación con el primero. El HDL-colesterol no tuvo una variación significativa durante el embarazo. Se concluye que los valores del colesterol total, los triglicéridos, el LDL-colesterol y el VLDL-colesterol varían en relación con el trimestre de la gestación, aumentan de forma significativa en el tercer trimestre en comparación con el primer trimestre del embarazo, en tanto el HDL-colesterol no varía significativamente durante el embarazo.

ABSTRACT In order to describe the lipid profile by trimesters of pregnancy in healthy pregnant women, a descriptive, cross-sectional study was conducted with 40 pregnant women between 20 and 35 years of age, from a universe of 110, belonging to the "Jimmy Hirzel" Hospital in Bayamo, Granma, between January 2017 and March 2019. The concentrations of total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and VLDL-cholesterol were determined. One-factor analysis of variance was used, and the Tukey's multiple comparison test of pairs of means Cholesterol, triglycerides, LDL-cholesterol, and VLDL-cholesterol varied significantly with gestational trimester total cholesterol increased in the second and third trimesters compared with the first, while triglycerides, LDL-cholesterol and VLDL-cholesterol increased in the third trimester compared to the first. HDL-cholesterol did not have a significant variation time during pregnancy. It is concluded that the values ​​of total cholesterol, triglycerides, LDL-cholesterol and VLDL-cholesterol vary in relation to the trimester of pregnancy, they increase significantly in the third trimester compared to the first trimester of pregnancy, while HDL-cholesterol does not vary significantly during pregnancy.

RESUMO Com o objetivo de descrever o perfil lipídico por trimestres de gestação em gestantes saudáveis, foi realizado um estudo descritivo, transversal, com 40 gestantes entre 20 e 35 anos, de um universo de 110, pertencentes ao grupo "Jimmy Hirzel" Hospital em Bayamo, Granma, entre janeiro de 2017 e março de 2019. Foram determinadas as concentrações de colesterol total, triglicerídeos, HDL-colesterol, LDL-colesterol e VLDL-colesterol. Foi utilizada a análise de variância de um fator e o teste de comparação múltipla de Tukey de pares de médias Colesterol, triglicerídeos, LDL-colesterol e VLDL-colesterol variou significativamente com o trimestre gestacional O colesterol total aumentou no segundo e terceiro trimestres em comparação com o primeiro, enquanto os triglicerídeos, LDL-colesterol e VLDL-colesterol aumentaram no terceiro trimestre comparado ao primeiro. O HDL-colesterol não teve variação significativa durante a gravidez. Conclui-se que os valores de colesterol total, triglicerídeos, LDL-colesterol e VLDL-colesterol variam em relação ao trimestre de gestação, aumentam significativamente no terceiro trimestre em relação ao primeiro trimestre de gestação, enquanto o HDL-colesterol não não variam significativamente durante a gravidez.

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INTRODUCTION: Bariatric surgery aims to reduce weight and resolve the comorbidities associated with obesity. Few studies have assessed mid/long-term changes in lipid profile with sleeve gastrectomy versus gastric bypass. This study was conducted to assess and compare changes in lipid profile with each procedure after 60 months. METHODS: This was an observational, retrospective study of analytical cohorts enrolling 100 patients distributed into two groups: 50 had undergone gastric bypass (GBP) surgery and 50 sleeve gastrectomy (SG) surgery. Total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) levels were measured before surgery and at 1, 6, 12, 24, 36, 48, and 60 months. Weight loss and the resolution of dyslipidemia with each of the procedures were also assessed. RESULTS: Ninety-five of the 100 patients completed follow-up. At 60 months, TC and LDL levels had significantly decreased in the BPG group (167.42 ±â€¯31.22 mg/dl and 88.06 ±â€¯31.37 mg/dl, respectively), while there were no differences in the SG group. Increased HDL levels were seen with both procedures (BPG: 62.69 ±â€¯16.3 mg/dl vs. SG: 60.64 ±â€¯18.73 mg/dl), with no difference between the procedures. TG levels decreased in both groups (BPG: 86.06 ±â€¯56.57 mg/dl vs. SG: 111.09 ±â€¯53.08 mg/dl), but values were higher in the BPG group (P < .05). The percentage of overweight lost (PSP) was higher in the BPG group: 75.65 ±â€¯22.98 mg/dl vs. the GV group: 57.83 ±â€¯27.95 mg/dl. CONCLUSION: Gastric bypass achieved better mid/long-term results in terms of weight reduction and the resolution of hypercholesterolemia as compared to sleeve gastrectomy. While gastric bypass improved all lipid profile parameters, sleeve gastrectomy only improved HDL and triglyceride levels.

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Introducción: El perfil lipídico mínimo está relacionado con la enfermedad vascular de tipo aterosclerótica, pero se desconoce cuál es el tipo de perfil más frecuente en los adultos y el tipo de riesgo que representan para la enfermedad vascular periférica de los miembros inferiores. Objetivo: Determinar si el perfil lipídico mínimo sirve para diagnosticar el riesgo de enfermedad vascular periférica de los miembros inferiores. Métodos: Se trabajó con 533 muestra sanguíneas de personas adultas de diferentes municipios de la provincia La Habana. Se cuantificaron las concentraciones de colesterol total y de triglicéridos. Se calculó la media y la desviación estándar. Se diagnosticó y clasificó la hiperlipemia, se identificó el riesgo de enfermedad vascular periférica de los miembros inferiores y su asociación con la hiperlipemia. Se trabajó con un nivel de confiabilidad del 95 por ciento (a=0,05). Resultados: Los perfiles lipídicos mínimos más frecuentes fueron: el hipercolesterolemia leve (46,0 por ciento) y la hipertrigliceridemia (22,6 por ciento). El 53,8 por ciento presentó riesgo de enfermedad vascular periférica de los miembros inferiores entre potencial (24,8 por ciento) y alto (29,0 por ciento). Existió una asociación entre la hiperlipemia y la presencia de enfermedades vasculares periféricas de los miembros inferiores (chi cuadrada= 120,4; p= 0,00000). Se detectó que el 50 por ciento de las personas requería de un tratamiento hipolipemiante. Conclusión: El perfil lipídico mínimo sirve para diagnosticar el tipo de riesgo de enfermedad vascular periférica de los miembros inferiores. Se observó una fuerte asociación de dicha enfermedad con la presencia de hiperlipemia(AU)

Introduction: The minimum lipid profile is related to atherosclerotic vascular disease, but it is not known what is the most common type in adults and the kind of risk it represent for peripheral vascular disease of the lower limbs. Objective: To determine if the minimum lipid profile is used to diagnose the risk of peripheral vascular disease of the lower limbs. Methods: It was carried out a study with 533 blood sample of adults from different municipalities in Havana province. Concentrations of total cholesterol and triglycerides were quantified. Average and standard deviation were calculated. Hyperlipidemia was diagnosed and classified, the risk of peripheral vascular disease of the lower limbs and the association of the latter with hyperlipidemia were identified. The level of reliability used was of 95 percent (a= 0.05). Results: The most common minimum lipid profiles were: mild hypercholesterolemia (46 percent) and hypertriglyceridemia (22.6 percent). 53.8 percent presented a risk of peripheral vascular disease of the lower limbs between potential (24.8 percent) and high (29 percent). There was a relation between the hyperlipidemia and the presence of peripheral vascular diseases of the lower limbs (chi-cudrada= 120.4, p= 0.00000). It was detected that 50 percent of the people required a hypolipidemic treatment. Conclusion: The minimum lipid profile is used to diagnose the risk's type of peripheral vascular disease of the lower limbs, observing a strong relation of the latter with the presence of hyperlipidemia(AU)

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Resumen Introducción: El impacto del cambio de terapia antiretroviral (TAR) para tratar la dislipidemia en pacientes infectados por VIH no ha sido reportado en Chile. Objetivo: Evaluar la efectividad y seguridad a 12 meses del cambio de TAR a esquema con raltegravir (RAL) para tratar la dislipidemia. Material y Métodos: Cohorte retrospectiva de pacientes con infección por VIH en TAR, atendidos en Fundación Arriarán, con dislipidemia y que cambiaron a esquema con RAL para tratarla. Resultados: Se incluyó 73 casos, en TAR con inhibidores no nucleosídicos de transcriptasa reversa (INNTR; 50,7%) o inhibidores de proteasa (IP; 49,3%), con dislipidemia mixta (42,5%) o hipertrigliceridemia aislada (57,5%). La mediana de colesterol total (CT) y triglicéridos (TG) basales era 228 mg/dl y 420 mg/dl, respectivamente. El 94,5% tenía carga viral (CV) indetectable. Se modificó TAR de base en 58,4%; 89,1% recibía hipolipemiantes. Las concentraciones plasmáticas de lípidos descendieron significativamente a 12 meses (TG= −43,6%; CT= −19,3%). Ningún paciente presentó fracaso virológico, aunque 10,9% tuvo viremia detectable a 12 meses, mayoritariamente transitoria. Conclusiones: El cambio de TAR a RAL en pacientes dislipidémicos tratados con INNTR o IP reduce significativamente las concentraciones plasmáticas de TG y CT a 12 meses. Es una estrategia segura, pero puede observarse viremia transitoria.

Background: The impact of switching antiretroviral therapy (ART) regimen for dyslipidemia management in HIV-infected (HIV+) patients has not been reported in Chile. Aim: To assess effectiveness and safety at 12 months after switching to raltegravir-based regimen for dyslipidemia management. Methods: Retrospective cohort of HIV+ patients receiving ART at Arriaran Foundation, with dyslipidemia switched to raltegravir-based regimen for lipid management. Results: 73 patients were included, receiving ART based in nonnucleoside reverse transcriptase inhibitor (NNRTI; 50,7%) or protease inhibitor (PI; 49,3%), with mixed dyslipidemia (42,5%) or isolated hypertriglyceridemia (57,5%). At baseline, median total cholesterol (TC) and triglycerides (TG) were 228 mg/dl and 420 mg/dl, respectively; undetectable viral load (VL) was present in 94,5% of patients. Backbone ART was switched in 58,4% and lipid-lowering therapy was used by 89,1% of them. At 12 months, there was a significant decrease in TG (-43,6%) and TC (-19,3%). No cases of virologic failure were observed, although 10,9% of patients had detectable VL at 12 months, mostly transient. Conclusions: Switching ART to raltegravir-based regimen in dyslipidemic patients receiving NNRTI or PI is associated with a significative decrease in TG and TC at 12 months. This strategy is safe, but VL can be increased temporarily.

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A proposta dessa pesquisa foi avaliar a associação entre a periodontite estabelecida e o perfil lipídico de pacientes da Faculdade de Odontologia da Universidade Federal do Rio de Janeiro. Este estudo transversal envolveu 70 indivíduos, sendo que, 30 apresentavam periodontite estabelecida (GP) e 40 não apresentavam esta condição (GC). Foi realizado um exame clínico periodontal onde foram avaliados: índice de placa visível, profundidade de bolsa à sondagem (PBS), nível clínico de inserção (NCI) e sangramento à sondagem (SS). A seguir, os pacientes, foram encaminhados para realização do exame de sangue, onde avaliaram os seguintes parâmetros: triglicerídeos (TGL), colesterol total (CT), colesterol LDL (LDL), colesterol HDL (HDL) e glicemia em jejum. Além disso, todos responderam a um questionário sobre os dados socioeconômicos. Os parâmetros de PBS e NCI foram categorizados em níveis rasos (0­3mm), médios (4­6mm) e profundos (>6mm). Para análise do perfil lipídico cada parâmetro foi avaliado separadamente de acordo com seu ponto de corte. Também foi criada uma variável denominada gradiente dislipidêmico, composta por: indivíduos sem dislipidemia, indivíduos com dislipidemia causada por apenas um parâmetro lipídico ou por indivíduos com dislipidemia causada por dois ou mais parâmetros lipídicos alterados. A comparação intergrupos dos dados socioeconômicos e da média da porcentagem dos parâmetros clínicos foram obtidas pelos testes de Qui-quadrado e Mann-Whitney. A associação entre periodontite e perfil lipídico foi avaliada através de uma regressão logística. O GP apresentou uma maior média de porcentagem de sítios moderados e profundos tanto para PBS quanto NCI quando comparado ao GC (p< 0,05). O GP apresentou um número significativamente maior de indivíduos com LDL e TGL alterados quando comparado ao GC (p < 0,05). Analisando o 'gradiente dislipidêmico', foi observado que 76% do GC e 24% do GP não possuíam dislipidemia. Dentre aqueles que apresentavam somente um tipo de alteração do perfil lipídico, 39% eram do GC e 61% eram do GP. E, aqueles que possuíam duas ou mais alterações, 30% eram do GC e 70% eram do GP. Após a regressão, foi visto que os indivíduos com apenas um parâmetro lipídico alterado apresentavam mais chance de desenvolver periodontite estabelecida quando comparados aos indivíduos do GC (OR: 4.59, 95%, IC: 1.45-14.5). Assim como, aqueles que apresentaram dois ou mais parâmetros lipídicos alterados, também apresentavam uma maior chance de desenvolver periodontite (OR: 5.84, 95%, IC: 1.20-28.37). Dessa forma, o estudo demonstrou uma associação entre periodontite estabelecida e a dislipidemia. (AU)

This study aims to evaluate the association between established periodontitis and lipid profile in patients from the Federal University Dental School. This cross sectional study involved a convenience sample of 70 subjects, out of them, 30 participants had established periodontitis (PG) and 40 individuals did not present this condition (CG). It was performed a clinical periodontal examination that evaluated visible plaque index (PI), pocket depth (PD), clinical attachment level (CAL) and bleeding on probing (BOP). In addition a blood analysis was conducted to evaluate: triglycerides (TGL), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) and fasting glucose. Furthermore, patients answered a socioeconomic questionnaire. The PD and CAL were categorized as shallow (0 ­ 3 mm), moderate (4 ­ 6 mm) and deep (≥ 7mm) sites and the average of percentage of sites was calculated for each group. For lipid profile analysis each lipid parameter was analyzed according to their cutoff point. In addition, was created a variable called "dyslipidemic gradient", involving 3 categories of individuals: with no dyslipidemia, with dyslipidemia caused by one lipid parameter and with dyslipidemia caused by two or more lipid parameters. The intergroup comparison of socioeconomic data and mean percentage of clinical parameters were obtained by Chi-square and Mann-Whitney test. The association between periodontitis and lipid profile was evaluated by logistic regression. The PG had a higher mean percentage of moderate and deep sites of CAL and PD when compared to CG (p < 0.05). The PG had a greater number of individuals with higher LDL and TGL when compared to the PG (p < 0.05). Analyzing the 'dyslipidemic gradient' it was observed that 76% of CG and 24% of PG were patients without dyslipidemia. Among patients with one lipid alteration, 39% were of CG and 61% were of PG. And, those patients who presented two or more lipid alterations, 30% were from CG and 70% were from PG. Individuals with dyslipidemia caused by only one lipid parameter had more chance of developing periodontitis compared to individuals of the CG (Odds ratio (OR) 4.59, 95%, IC: 1.45 - 14.52). Subjects with dyslipidemia caused by two or more lipid parameters, still had more chance to have periodontitis (OR) 5.84 , 95%, IC: 1.20 ­ 28.37). This study demonstrated an association between established periodontitis and dyslipidemia. (AU)

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Introducción: actualmente hay consenso en que el proceso aterosclerótico se inicia en la infancia, y la dislipidemia es uno de los principales factores de riesgo aterogénicos que deben ser estudiados, así como la valoración nutricional para una adecuada prevención. Objetivo: identificar algunas señales de aterosclerosis tempranas como el sobrepeso y las dislipidemias en adolescentes. Métodos: se realizó un estudio descriptivo transversal de 372 adolescentes de la Secundaria Básica Protesta de Baraguá. Se hicieron mediciones de peso, talla, índice de masa corporal y circunferencia de la cintura. Se tomó muestra de sangre venosa con ayuno de 12 horas. Se midió el colesterol total, el colesterol unido a lipoproteína baja y alta densidad, y triglicéridos. En el análisis estadístico se realizaron prueba de comprobación de media entre variables de valoración nutricional y lipídicas entre sexos (prueba t), y se trabajó con una probabilidad de error menor de 0,05. Resultados: la media del peso, talla y circunferencia de la cintura fueron mayores en el sexo masculino (p< 0,05). El exceso de peso fue 23,7 por ciento, y a partir del percentil 90-97 hubo un 21,8 por ciento de exceso de grasa abdominal. La media del colesterol total, lipoproteínas de alta y baja densidad y triglicéridos, fue similar en los diferentes sexos, sin relación significativa (p> 0,05). El 18,5 por ciento presentó colesterol total limítrofe alto, el 26,6 por ciento tenía triglicéridos limítrofe alto y 7,5 Overweight and dyslipidemias in teenagers alto, con predominio del sexo femenino. Conclusiones: alrededor de la cuarta parte de los adolescentes tenían exceso de peso e incremento de la grasa abdominal, casi la cuarta parte tenía el colesterol total limítrofe y alto, y la alteración lipídica observada con mayor frecuencia fue la hipertrigliceridemia(AU)

Introduction: there is a current consensus that the atherosclerotic process begins at childhood and that dyslipidemia is one of the atherogenic risk factors to be studied together with the nutritional assessment for the adequate prevention of atherosclerosis. Objective: to identify some early signs of atherosclerosis such as overweight and dyslipidemias in teenagers. Methods: a cross-sectional descriptive study of 372 teenagers from Protesta de Baragua junior high school. Weight, height, body mass index and waist circumference were measured. Blood samples were taken after 12 hour fasting. Total cholesterol, low and high density lipoprotein cholesterol and triglyceride were all measured. The statistical analysis included the t test among nutritional assessment and lipid variables between sexes and the error probability was lower than 0.05. Results: weight, height and waist circumference means were higher in males (p< 0.05). Overweight was 23.7 percent and from the 90-97th percentile, the excessive abdominal fat was 21.8 percent. The mean of total cholesterol, high and low density lipoproteins and triglycerides was similar in both sexes, with no significant relation (p> 0.05). In this group, 18.5 of adolescents presented with borderline high total cholesterol, 26.6 showed borderline high triglyceride rate and 7.5 percent had high cholesterol, being females predominant. Conclusions: one fourth of adolescents approximately exhibited overweight and increased abdominal fat; almost 25 percent had reached borderline and high total cholesterol whereas the most observed lipid disorder was hypertrigliceridemia(AU)

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INTRODUCCIÓN: actualmente hay consenso en que el proceso aterosclerótico se inicia en la infancia, y la dislipidemia es uno de los principales factores de riesgo aterogénicos que deben ser estudiados, así como la valoración nutricional para una adecuada prevención. OBJETIVO: identificar algunas señales de aterosclerosis tempranas como el sobrepeso y las dislipidemias en adolescentes. MÉTODOS: se realizó un estudio descriptivo transversal de 372 adolescentes de la Secundaria Básica "Protesta de Baraguá". Se hicieron mediciones de peso, talla, índice de masa corporal y circunferencia de la cintura. Se tomó muestra de sangre venosa con ayuno de 12 horas. Se midió el colesterol total, el colesterol unido a lipoproteína baja y alta densidad, y triglicéridos. En el análisis estadístico se realizaron prueba de comprobación de media entre variables de valoración nutricional y lipídicas entre sexos (prueba t), y se trabajó con una probabilidad de error menor de 0,05. RESULTADOS: la media del peso, talla y circunferencia de la cintura fueron mayores en el sexo masculino (p< 0,05). El exceso de peso fue 23,7 %, y a partir del percentil 90-97 hubo un 21,8 % de exceso de grasa abdominal. La media del colesterol total, lipoproteínas de alta y baja densidad y triglicéridos, fue similar en los diferentes sexos, sin relación significativa (p> 0,05). El 18,5 % presentó colesterol total limítrofe alto, el 26,6 % tenía triglicéridos limítrofe alto y 7,5 % alto, con predominio del sexo femenino. CONCLUSIONES: alrededor de la cuarta parte de los adolescentes tenían exceso de peso e incremento de la grasa abdominal, casi la cuarta parte tenía el colesterol total limítrofe y alto, y la alteración lipídica observada con mayor frecuencia fue la hipertrigliceridemia.

INTRODUCTION: there is a current consensus that the atherosclerotic process begins at childhood and that dyslipidemia is one of the atherogenic risk factors to be studied together with the nutritional assessment for the adequate prevention of atherosclerosis. OBJECTIVE: to identify some early signs of atherosclerosis such as overweight and dyslipidemias in teenagers. METHODS: a cross-sectional descriptive study of 372 teenagers from "Protesta de Baragua" junior high school. Weight, height, body mass index and waist circumference were measured. Blood samples were taken after 12 hour fasting. Total cholesterol, low and high density lipoprotein cholesterol and triglyceride were all measured. The statistical analysis included the t test among nutritional assessment and lipid variables between sexes and the error probability was lower than 0.05. RESULTS: weight, height and waist circumference means were higher in males (p< 0.05). Overweight was 23.7 % and from the 90-97th percentile, the excessive abdominal fat was 21.8 %. The mean of total cholesterol, high and low density lipoproteins and triglycerides was similar in both sexes, with no significant relation (p> 0.05). In this group, 18.5 % of adolescents presented with borderline high total cholesterol, 26.6 % showed borderline high triglyceride rate and 7.5 % had high cholesterol, being females predominant. CONCLUSIONS: one fourth of adolescents approximately exhibited overweight and increased abdominal fat; almost 25 % had reached borderline and high total cholesterol whereas the most observed lipid disorder was hypertrigliceridemia.

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AIM: To characterize the distribution of total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C) and triglycerides in primary health care users. METHODS: We performed a cross-sectional study in a primary care setting, involving 719 general practitioners based on stratified distribution proportional to the population density of each region of Portugal. The first two adult patients scheduled for an appointment on a given day were invited to participate. A questionnaire was applied to assess sociodemographic, clinical and laboratory data including lipid profile. RESULTS: The study included 16 856 individuals (mean age 58.1±15.1 years; 61.6% women). Data on TC, LDL-C, HDL-C and triglycerides were available for 95.9% (n=16 159), 59.1% (n=9956), 95.4% (n=16 074) and 97.9% (n=16 494) of the population, respectively. Hypercholesterolemia (TC ≥200 mg/dl) was detected in 47%, and 38.4% had high levels of LDL-C (≥130 mg/dl). Hypertriglyceridemia (≥200 mg/dl) and low HDL-C (<40 mg/dl) were less prevalent, affecting roughly 13% of the population. Dyslipidemia was more common in middle-aged men and in post-menopausal women. Of the population aged over 40, 54.1% met eligibility criteria for lipid-lowering therapy and 44.7% were medicated with statins, but only 16.0% of these had TC ≤175 mg/dl. CONCLUSIONS: Dyslipidemia is highly prevalent in primary health care users in Portugal. It is particularly common in middle-aged men and post-menopausal women, who should be considered target groups for preventive public health measures.

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Plasma low-density lipoprotein cholesterol (LDL-C) levels are a key determinant of the risk of cardiovascular disease, which is why many studies have attempted to elucidate the pathways that regulate its metabolism. Novel latest-generation sequencing techniques have identified a strong association between the 1p13 locus and the risk of cardiovascular disease caused by changes in plasma LDL-C levels. As expected for a complex phenotype, the effects of variation in this locus are only moderate. Even so, knowledge of the association is of major importance, since it has unveiled a new metabolic pathway regulating plasma cholesterol levels. Crucial to this discovery was the work of three independent teams seeking to clarify the biological basis of this association, who succeeded in proving that SORT1, encoding sortilin, was the gene in the 1p13 locus involved in LDL metabolism. SORT1 was the first gene identified as determining plasma LDL levels to be mechanistically evaluated and, although the three teams used different, though appropriate, experimental methods, their results were in some ways contradictory. Here we review all the experiments that led to the identification of the new pathway connecting sortilin with plasma LDL levels and risk of myocardial infarction. The regulatory mechanism underlying this association remains unclear, but its discovery has paved the way for considering previously unsuspected therapeutic targets and approaches.

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Introducción: el linfedema es una enfermedad crónica, con tasas de incidencia y prevalencia que van en aumento y con efectos negativos sobre la calidad de vida de los enfermos.Objetivo: describir el comportamiento de algunos parámetros bioquímicos en personas con linfedema secundario de miembros inferiores. Métodos: estudio descriptivo de corte transversal en las 16 personas con linfedema secundario de miembros inferiores detectadas en el municipio Cerro, con un rango de edad que osciló entre 18 y 72 años, 10 eran mujeres (62,5 por ciento) y seis eran hombres (37,5 por ciento). Se cuantificaron los siguientes parámetros bioquímicos: glucosa, colesterol total, triglicéridos, fibrinógeno, y Factor VII. Se analizó el comportamiento de las variables de forma global e individualizada.Resultados: al analizar de forma individual el comportamiento de las variables, de acuerdo a los límites de normalidad publicados por los fabricantes de los diagnosticadores, se halló que más del 50 por ciento de los pacientes tuvieron cifras normales; por debajo de los límites inferiores se encontraron el colesterol total en 7 (43,75 por ciento) pacientes, los triglicéridos en 2 (12,5 por ciento) y la glucosa en 5 (31,25 por ciento), sin constatar ninguno con cifras elevadas; sin embargo, esto último si fue apreciado, con igual frecuencia, en el caso del FVII y el fibrinógeno, en 4 (25 por ciento) enfermos, respectivamente.Conclusión: los resultados obtenidos no permitieron seleccionar ningún parámetro como marcador propio del linfedema, pero sí contribuirán a elevar el nivel de conocimiento de esta enfermedad poco estudiada(AU)

Introduction: lymphedema is a chronic illness, with rates of incidence and prevalence that are on the rise and with negative effects on the patients' quality of life.Objective: To describe the behaviour of some biochemical parameters in patients with secondary lymphedema of the lower limbs. Methods: a descriptive cross-sectional study conducted in 16 persons with secondary lymphedema of the lower limbs, who were detected in Cerro municipality; 10 were women (62.5 percent) and six were men (37.5 percent) aged 18 to 72 years. The following biochemical parameters were quantitated: glucose, total cholesterol, triglycerides, fibrinogen, and Factor VII. The behaviour of the variables were globally and individually analyzed. Results: according to the normal limits set by the manufacturers of diagnostics, the analysis of the individual behaviour found that more than 50 percent of the patients presented normal figures; values lower than the limit figures were found in total cholesterol (n=7, 43.75 percent), triglycerides (n=2, 12.50 percent,) and glucose (n=5, 31.25 percent); however, high figures were equally observed in the case of Factor VII and fibrinogen (n=4, 25 percent) respectively.Conclusions: It may be stated that the obtained results did not allow selecting any parameter as the right marker of lymphedema, but did help to raise the level of knowledge on this poorly studied disease(AU)

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Objetivo: Determinar si la disminución promedio del colesterol total y LDL- colesterol es mayor en pacientes adultos con diagnóstico de hipercolesterolemia que reciben una dieta hipocolesterolémica sumada a un probiótico en comparación con aquellos que reciben sólo dieta. Materiales y métodos: Ensayo clínico controlado y aleatorizado. La muestra estuvo conformada por 46 pacientes de ambos sexos que asistieron a los consultorios externos del Hospital Piñero con diagnóstico de hipercolesterolemia durante los meses de Agosto de 2009 a Abril de 2011. Los mismos fueron asignados a dos grupos: uno que recibió una dieta hipocolesterolémica y otro la misma dieta sumada a un producto lácteo que contiene la cepa probiótica Lactobacillus Casei Shirota. Resultados: En el caso del colesterol total no se hallaron diferencias significativas en el promedio de descenso del mismo entre el grupo que realizó la dieta hipocolesterolémica y el que realizó la misma dieta sumada al consumo del probiótico (p=0,386), al mismo tiempo que sí se pudo observar una diferencia significativa (p<0,001) entre el colesterol total inicial y el final en ambos. En lo que respecta al LDL-colesterol tampoco se hallaron diferencias significativas en el promedio de descenso del mismo entre ambos grupos (p=0,313), aunque hubo una diferencia significativa (p<0,001) entre el LDL-colesterol inicial y el final. Conclusiones: En este estudio no se han encontrado diferencias significativas en el descenso promedio del colesterol total y el LDL-colesterol en el grupo que realizó la dieta hipocolesterolémica sola en comparación con el que realizó la dieta y consumió el probiótico. Sin embargo, los resultados obtenidos permiten confirmar que la adopción de un plan alimentario destinado a lograr la reducción de los niveles de colesterol total y LDL- colesterol resulta efectivo, constituyéndose en un pilar fundamental para la prevención y tratamiento de las enfermedades cardiovasculares.

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Objetivo: Determinar si la disminución promedio del colesterol total y LDL- colesterol es mayor en pacientes adultos con diagnóstico de hipercolesterolemia que reciben una dieta hipocolesterolémica sumada a un probiótico en comparación con aquellos que reciben sólo dieta. Materiales y métodos: Ensayo clínico controlado y aleatorizado. La muestra estuvo conformada por 46 pacientes de ambos sexos que asistieron a los consultorios externos del Hospital Piñero con diagnóstico de hipercolesterolemia durante los meses de Agosto de 2009 a Abril de 2011. Los mismos fueron asignados a dos grupos: uno que recibió una dieta hipocolesterolémica y otro la misma dieta sumada a un producto lácteo que contiene la cepa probiótica Lactobacillus Casei Shirota. Resultados: En el caso del colesterol total no se hallaron diferencias significativas en el promedio de descenso del mismo entre el grupo que realizó la dieta hipocolesterolémica y el que realizó la misma dieta sumada al consumo del probiótico (p=0,386), al mismo tiempo que sí se pudo observar una diferencia significativa (p<0,001) entre el colesterol total inicial y el final en ambos. En lo que respecta al LDL-colesterol tampoco se hallaron diferencias significativas en el promedio de descenso del mismo entre ambos grupos (p=0,313), aunque hubo una diferencia significativa (p<0,001) entre el LDL-colesterol inicial y el final. Conclusiones: En este estudio no se han encontrado diferencias significativas en el descenso promedio del colesterol total y el LDL-colesterol en el grupo que realizó la dieta hipocolesterolémica sola en comparación con el que realizó la dieta y consumió el probiótico. Sin embargo, los resultados obtenidos permiten confirmar que la adopción de un plan alimentario destinado a lograr la reducción de los niveles de colesterol total y LDL- colesterol resulta efectivo, constituyéndose en un pilar fundamental para la prevención y tratamiento de las enfermedades cardiovasculares.(AU)

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Objetivo: Determinar si la disminución promedio del colesterol total y LDL- colesterol es mayor en pacientes adultos con diagnóstico de hipercolesterolemia que reciben una dieta hipocolesterolémica sumada a un probiótico en comparación con aquellos que reciben sólo dieta. Materiales y métodos: Ensayo clínico controlado y aleatorizado. La muestra estuvo conformada por 46 pacientes de ambos sexos que asistieron a los consultorios externos del Hospital Piñero con diagnóstico de hipercolesterolemia durante los meses de Agosto de 2009 a Abril de 2011. Los mismos fueron asignados a dos grupos: uno que recibió una dieta hipocolesterolémica y otro la misma dieta sumada a un producto lácteo que contiene la cepa probiótica Lactobacillus Casei Shirota. Resultados: En el caso del colesterol total no se hallaron diferencias significativas en el promedio de descenso del mismo entre el grupo que realizó la dieta hipocolesterolémica y el que realizó la misma dieta sumada al consumo del probiótico (p=0,386), al mismo tiempo que sí se pudo observar una diferencia significativa (p<0,001) entre el colesterol total inicial y el final en ambos. En lo que respecta al LDL-colesterol tampoco se hallaron diferencias significativas en el promedio de descenso del mismo entre ambos grupos (p=0,313), aunque hubo una diferencia significativa (p<0,001) entre el LDL-colesterol inicial y el final. Conclusiones: En este estudio no se han encontrado diferencias significativas en el descenso promedio del colesterol total y el LDL-colesterol en el grupo que realizó la dieta hipocolesterolémica sola en comparación con el que realizó la dieta y consumió el probiótico. Sin embargo, los resultados obtenidos permiten confirmar que la adopción de un plan alimentario destinado a lograr la reducción de los niveles de colesterol total y LDL- colesterol resulta efectivo, constituyéndose en un pilar fundamental para la prevención y tratamiento de las enfermedades cardiovasculares.(AU)

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The performance of lab tests (LT) and blood testing devices (BTD) to monitor glycemia vs. glycated hemoglobin A1c (A1c) were compared. In addition, the performance of blood glucose, total cholesterol (TC) and triacylglycerol measured by LT and BDT were compared. All parameters were measured based on the same blood samples from overnight fasted type 2 diabetic patients (T2DP). Linear regression analysis was used for all comparisons. The results showed that A1c correlated better with LT-glucose (r = 0.58) than BTD-glucose (r = 0.42). Moreover, LT vs. BTD showed r values of 0.90, 0.82 and 0.92 for glucose, TC and triacylglycerol, respectively. It was concluded that the performance of LT-glucose was better than BDT-glucose. Moreover, since triacylycerol and TC measured by BTD correlated better with LT compared to BDT-glucose vs. LT-glucose, the inclusion of BTD-TC and BTD-triacylglycerol for detecting and monitoring hyperlipidemia in T2DP should be considered.

Comparou-se a performance de avaliação da glicemia através de dosagens laboratoriais (DL) ou dispositivo para teste de sangue capilar (DTSC) vs. hemoglobina glicada A1c (A1c). Comparou-se ainda a performance de avaliação da glicemia, colesterol total (CT) e triacilglicerol (DL vs. DTSC). Avaliou-se estes parametros a partir das mesmas amostras de sangue coletadas em pacientes diabéticos tipo 2 (PDT2) em jejum noturno, sendo as comparações realizadas através de análise de regressão linear. A A1c correlacionou-se melhor com a glicemia-DL (r = 0,58) em relação a glicemia-DTSC (r = 0,42). Comparou-se DL vs. DTSC obtendo se r = 0,90, 0,82 e 0,92 para glicemia, CT e triacilglicerol, respectivamente. Concluiu-se que houve melhor performance da glicose-DL em relação a glicose-DTSC. Além disso, considerando que o triacilglicerol e TC avaliado através de DTSC correlaciona-se melhor com DL em comparação a DTSC-glicose vs. DL-glicose, a inclusão de DTSC-TC e DTSC-triacilglicerol visando detectar e monitorar hyperlipidemia in PDT2 deve ser considerada.

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JUSTIFICATIVA E OBJETIVOS: A intolerância à glicose (IG) é uma condição clínica que carreia consigo um relevante significado clínico por estar associada à maior risco de desenvolvimento de diabetes mellitus (DM) e eventos cardiovasculares. O objetivo deste estudo foi avaliar o perfil lipoproteico dos pacientes com IG no momento do seu diagnóstico.MÉTODO: Estudou-se 85 pacientes não diabéticos com uma ou mais condições de risco para desenvolvimento de diabetes mellitus, que foram submetidos ao teste oral de tolerância à glicose com 75 g de carga glicídica (GTT). Os pacientes foram divididos em dois grupos: grupo I (GTT < 140 mg/dL) e grupo II (GTT ≥ 140 mg/dL), avaliando-se dosagens séricas em jejum de: colesterol total (CT), HDL - colesterol (HDL-c), LDL - colesterol (LDL-c) e triglicerídeos. As variáveis contínuas dos dados laboratoriais foram expressas em média ± desvio-padrão. As diferenças entre as variáveis contínuas foram determinadas por meio do teste t de Student. O nível de significância estatística foi definido em 0,05. RESULTADOS: Na amostra estudada, a incidência de IG foi de 40%, sendo: grupo II com n = 34 e grupo I com n = 51. Em relação ao grupo I o grupo II demonstrou menor valor de CT (187,68 mg/dL ± 39,72 versus 212,81 mg/dL ± 39,79, p = 0,03); menor nível de LDL-c (113,75 mg/dL ± 35,31 versus 134,06 mg/dL ± 31,40, p = 0,02); menor nível de HDL-c (45,00 mg/dL ± 11,41 versus 54,98 mg/dL ± 13,92, p = 0,01). Não foram observadas diferenças significativas nos demais parâmetros laboratoriais avaliados. CONCLUSÃO: Os pacientes com IG apresentaram menores níveis de lipoproteínas do colesterol quando comparados àqueles com tolerância a glicose preservada.

BACKGROUND AND OBJECTIVES: Glucose intolerance (GI) is a clinical condition that improves the risk developing diabetes and cardiovascular events. The aim of the study was to evaluate the lipoprotein profile at the time of GI diagnosis. METHOD: We analyzed 85 non diabetic patients with at least one of the risk factors for diabetes, which performed a glucose tolerance test (GTT). They were divided into either group I (GTT < 140 mg/dL) and group II (GTT ≥ 140 mg/dL) and determined total cholesterol (TC), HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c) and triglycerides (TG). Numerical variables were summarized with the use of means ± standard-deviation. All comparisons between the numerical variables were performed with the use of the Student t test. The statistical tests were performed at a significance level of 0.05. RESULTS: The glucose intolerance incidence were 40%, the group II (n = 34) when compared to group I (n = 51) revealed lower TC (187.68 mg/dL ± 39.72 vs. 212.81 mg/dL ± 39.79, p = 0.03); LDL-c (113.75 mg/dL ± 35.31 vs. 134.06 mg/dL ± 31.40, p = 0.02) and HDL-c (45.00 mg/dL ± 11.41 vs. 54.98 mg/dL ± 13.92, p = 0.01). There were no differences between other variables.CONCLUSION: The glucose intolerance individuals presented lower TC, LDL-c, and HDL-c at the time of glucose intolerance diagnosis, when compared to the normal glucose tolerance individuals.

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FUNDAMENTO: O exercício físico aeróbico é importante aliado no combate aos fatores de risco cardiovascular. No entanto, os efeitos de exercícios de alta intensidade sobre tais fatores ainda são pouco conhecidos. OBJETIVO: Comparar os efeitos de protocolos de exercícios aeróbico e anaeróbico sobre fatores associados ao risco cardíaco. MÉTODOS: Vinte e dois indivíduos com idade média de 40±8 anos foram alocados nos grupos: controle (CO), treinamento de endurance (ET) e treinamento intermitente (IT). Os protocolos tiveram duração de 12 semanas, três vezes por semana; e intensidades de 10 por cento abaixo e 20 por cento acima do limiar anaeróbico (LAn). Foram medidas: massa corporal total (MCT), índice de massa corporal (IMC), circunferências de cintura (CINT) e quadril (QUA) e a composição corporal, além das concentrações plasmáticas de glicose (GLI), colesterol total (CHO) e triglicérides (TG); ainda foram calculados a razão cintura-quadril (PCCQ) e o índice de conicidade (Índice C). RESULTADOS: As variáveis de MCT, IMC, CINT, GLI e a composição corporal apresentaram alterações significativas nos grupos ET e IT. Os valores de CHO e QUA foram significativamente reduzidos no grupo ET, enquanto a PCCQ mostrou redução significativa no grupo IT. O LAn e o índice C, no grupo IT foram significativamente diferentes em relação a ET. CONCLUSÃO: Tendo em vista as diferenças encontradas nas respostas das variáveis estudadas, em razão do treinamento empregado, concluímos que um programa de exercício que contemple atividades de alta e baixa intensidades seja mais completo para garantir a redução de maior número de variáveis de risco cardíaco.

BACKGROUND: Aerobic exercise is an important ally in the fight against cardiovascular risk factors. However, the effects of high-intensity exercise on these factors are still poorly known. OBJECTIVE: To compare the effects of aerobic and anaerobic exercise protocols on cardiac risk factors. METHODS: 22 individuals with mean age of 40±8 years were distributed into the following groups: control (CO), endurance training (ET) and interval training (IT). The protocols lasted 12 weeks, three times a week, with intensities of 10 percent below and 20 percent above the anaerobic threshold (AnT). The following measurements were taken: total body mass (TBM), body mass index (BMI), waist circumference (WC), hip circumference (HC), and body composition, in addition to plasma concentrations of glucose (GLU), total cholesterol (CHO), and triglycerides (TG). Waist-hip ratio (WHR) and conicity index (C index) were also calculated. RESULTS: The TBM, BMI, WC, GLU, and body composition variables showed significant changes in the ET and IT groups. CHO and HC values were significantly reduced in the ET group, whereas WHR showed a significant reduction in the IT group. AnT and C index in the IT group were significantly different in relation to ET. CONCLUSION: In view of the differences found in the results of the variables studied in relation to the training performed, we conclude that an exercise program that includes both high and low-intensity activities is more efficient to ensure the reduction of a greater number of cardiac risk variables.

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Introdução: O objetivo do presente estudo foi analisar a eficácia da utilização da Cordia salicifolia em camundongos submetidos a dieta hiperlipidêmica, através do monitoramento dos índices sorológicos de colesterol e triglicerídeos. Metodologia: Para o experimento foram usados camundongos (mus musculus), com peso médio de 54 ± 5 g, e com idade de 50 ± 5 dias, que foram divididos em 4 grupos de 10 animais. Camundongos recebendo água e com dieta normal, camundongos recebendo água e com dieta hiperlipidêmica, camundongos com dieta normal e administração do extrato de Cordia salicifolia e camundongos com dieta hiperlipidêmica e administração do extrato de Cordia salicifolia. Resultados e conclusões: Houve redução nos níveis séricos de colesterol total, tanto no grupo que recebeu dieta normal + extrato como no grupo com dieta hiperlipidêmica + extrato. Também foi significativa a redução nos níveis séricos de triglicerídeos nos animais que receberam dieta hiperlipidêmica + extrato, quando comparados aos camundongos que receberam dieta hiperlipidêmica + água (AU)

Introduction: The present study evaluates the effectiveness of Cordia salicifolia in reducing serum total cholesterol and triglyceride levels in mice on a hyperlipidemic diet. Methodology: 40 specimens of mice (Mus musculus, mean weight 54 ±5 g and mean age 50 ± 5 days) were studied. They were divided into 4 groups of 10 animals each: mice on a normal diet receiving water, mice on a hyperlipidemic diet receiving water, mice on a normal diet receiving Cordia salicifolia extract, and mice on a hyperlipidemic diet receiving Cordia salicifolia extract. Results and conclusion: There was a serum total cholesterol reduction in the normal diet + extract group as well as in the hyperlipidemic diet + extract group. Also, the serum triglyceride reduction observed in animals on the hyperlipidemic diet + extract was significant as compared to mice on the hyperlipidemic diet + water (AU)

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The diet potential for increasing serum total cholesterol level (TOTAL-C) and developing atherosclerosis has been associated with intake of saturated fat and cholesterol. The objective of this study was to identify the association between food frequency consumption and TOTAL-C. These observations were collected during a cross-sectional examination, in a representative sample of 1045 adults, both sex, of 20 years of age and over, from Cotia City, São Paulo, Brazil. The variables studied were: food consumption (examined by food frequency questionnaire), TOTAL-C, and other variables. The association between TOTAL-C levels among the population studied was analyzed by multiple linear regression model (step-wise-forward) adjusted by: age, gender, body mass index (BMI), waist to hip ratio (W/H), educational level, family income, physical activity, smoking and alcohol consumption. Consumption of: chicken meat, red meat, pork, liver and processed meat, eggs, dairy food, showed significant and positive relationship with TOTAL-C (15.5, 14.0, 10.6, 17.1, 8.2, 4.4) mg/dL, respectively. Fruit and vegetables consumption were inversely related to TOTAL-C (-8.2, -7.2) mg/ dL, respectively. We observed that as food consumption contributes to TOTAL-C concentration variation, risk factors for coronary heart disease may be lowered by healthy food habits.

O potencial da dieta em aumentar níveis de colesterol sérico e promover aterosclerose está diretamente relacionado com o seu conteúdo de colesterol e gordura saturada. O propósito deste estudo foi identificar a associação entre a freqüência de consumo alimentar e níveis séricos de colesterol. Trata-se de um estudo transversal, em uma amostra representativa de 1 045 adultos de ambos os sexos, de 20 anos ou mais, residentes no Município de Cotia, São Paulo, Brasil. As variáveis estudadas foram: consumo de alimentos através da freqüência de consumo alimentar, o nível de colesterol sérico, e outras variáveis. Foi elaborado modelo de regressão linear múltipla (step-wiseforward) para colesterol total ajustados por: idade, sexo, índice de massa corpórea, relação cintura quadril, nível educacional, renda familiar, atividade física, tabagismo, etilismo. Os consumos de: carnes de aves, carne bovina, carne suína, vísceras e carnes processadas, ovos e leite e derivados foram associados positiva e significativamente com os níveis de colesterol total em: (15.5; 14.0; 10.6; 17.1; 8.2 e 7.2) mg/dl, respectivamente. O consumo de frutas e hortaliças foi associado inversa e significativamente com os níveis de colesterol total em -8.2 e -5.5 mg/dl, respectivamente. Os hábitos alimentares contribuem para as variações na concentração dos lipídios séricos, redução nos riscos para doenças cardiovasculares podem ser alcançados por meio de hábitos alimentares saudáveis.

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La hipertensión arterial complica 6-8% de todos los embarazos, es una de las causas principales de morbi-mortalidad materna y fetal siendo especialmente fatal en países con bajo nivel socioeconómico. La importancia de su estudio radica en que una atención prenatal adecuada previene o atenúa las alteraciones que provoca. Con el presente trabajo se intento buscar una relación PRONOSTICA entre parámetros laboratoriales tales como: perfil lipidico, ácido úrico, recuento plaquetario en pacientes preeclampticas, la correlación con la severidad del cuadro y los resultados perinatales obtenidos. Para tal efecto se realizó un estudio descriptivo, transversal y prospectivo donde 57 pacientes cumplieron los criterios de inclusión. No se observaron alteraciones en las lipoproteínas de alta y baja densidad, así como del colesterol total, pero se observo que un 35 % de las pacientes presentaron niveles de triglicéridos alterados, de ellas la mayor parte con diagnostico de preeclampsia severa.

The high blood pressure complícate 6-8% of all pregnancy. It is a major cause of mother and fetal morbi mortality, being specially fatal in low developed countries. It is important study because a adecuated pre partum care can prevent or at least attenuate its ateration. In the present work we search a pronostic relationship between laboratorial parameters such as : lipidic profile, uric acid, plateleds count in pre eclamptic patients, the correlation between severity and perinatal outcomes. In order to these we give an descriptive, transversal and prospective study, in which were included 57 patients that accomplished the inclusión criteria. It was not observed alterations on high and low density lipoproteins, neither total cholesterol, it was observed in 35% of patients triglycerides levels alterations, the most of them have been diagnosticated with severe preeclampsia.

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