RESUMEN

Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77-fold increased risk of for RA (P = 0.0032). No association was observed for IL-12B and IFN-γ polymorphisms. Our finds suggest a possible role for IL-18 polymorphism in the RA susceptibility in studied population.

Asunto(s)

Artritis Reumatoide/genética , Predisposición Genética a la Enfermedad , Interferón gamma/genética , Subunidad p40 de la Interleucina-12/genética , Interleucina-18/genética , Polimorfismo de Nucleótido Simple , Adulto , Alelos , Artritis Reumatoide/inmunología , Artritis Reumatoide/patología , Brasil , Estudios de Casos y Controles , Femenino , Expresión Génica , Frecuencia de los Genes , Humanos , Interferón gamma/inmunología , Subunidad p40 de la Interleucina-12/inmunología , Interleucina-18/inmunología , Masculino , Persona de Mediana Edad , Proyectos Piloto , Reacción en Cadena de la Polimerasa , Polimorfismo de Longitud del Fragmento de Restricción , Riesgo