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Interleukin-18, interleukin-12B and interferon-γ gene polymorphisms in Brazilian patients with rheumatoid arthritis: a pilot study.
Angelo, H D; Gomes Silva, I I F; Oliveira, R D R; Louzada-Júnior, P; Donadi, E A; Crovella, S; Maia, M M D; de Souza, P R E; Sandrin-Garcia, P.
Afiliación
  • Angelo HD; Department of General Formation, Federal Institute of Pernambuco, Garanhuns, Pernambuco, Brazil.
  • Gomes Silva II; Postgraduate Program in Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
  • Oliveira RD; Postgraduate Program in Applied Molecular and Cellular Biology, University of Pernambuco (ICB/UPE), Recife, Pernambuco, Brazil.
  • Louzada-Júnior P; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Donadi EA; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Crovella S; Division of Clinical Immunology, Department of Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
  • Maia MM; Department of Genetics, Federal University of Pernambuco, Recife, Pernambuco, Brazil.
  • de Souza PR; Department of Biology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
  • Sandrin-Garcia P; Department of Biology, Federal Rural University of Pernambuco, Recife, Pernambuco, Brazil.
Tissue Antigens ; 86(4): 276-8, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26302971
Polymorphisms in interleukin (IL)-18, IL-12 and interferon (IFN)-γ genes are associated with different levels of cytokines expression and have been associated with rheumatoid arthritis (RA). IL-18 +105 A/C, IL-12B +1188 A/C and IFN-γ +874 T/A polymorphisms were analyzed by restriction fragment length polymorphism-polymerase chain reaction (PCR) and amplification refractory mutation system PCR from 90 RA patients and 186 healthy individuals. There were significant differences to IL-18 +105 A/C polymorphism between the RA and control groups (odds ratio = 3.77; P < 0.0001). Individual carriers of the variant allele C had a 3.77-fold increased risk of for RA (P = 0.0032). No association was observed for IL-12B and IFN-γ polymorphisms. Our finds suggest a possible role for IL-18 polymorphism in the RA susceptibility in studied population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Interferón gamma / Predisposición Genética a la Enfermedad / Interleucina-18 / Polimorfismo de Nucleótido Simple / Subunidad p40 de la Interleucina-12 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Tissue Antigens Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Interferón gamma / Predisposición Genética a la Enfermedad / Interleucina-18 / Polimorfismo de Nucleótido Simple / Subunidad p40 de la Interleucina-12 Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: America do sul / Brasil Idioma: En Revista: Tissue Antigens Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido