RESUMEN
Despite the existence of organised crime in Slovakia, no case has ever been monitored in which one individual used a firearm against several people, as happens in the U.S. or in Western Europe. The aim of this work is to demonstrate a "unique" case in the history of Slovak criminality, when six members of one family were killed and some other accidental victims were wounded or even killed by one perpetrator using a firearm.
Asunto(s)
Armas de Fuego , Homicidio , Heridas por Arma de Fuego , Familia , Humanos , EslovaquiaRESUMEN
The investigation of motivation of suicidal behaviour in cases of so-called extended suicide is of great importance from a forensic-psychological viewpoint. The initiator of such action is often a person suffering from endogenous depression. The motives behind successful suicide are generally not known. This paper aims to demonstrate the motives behind the successful suicide, less frequent in our conditions, of two family members - a father and a son. The case has been thoroughly analysed by morphological methods with the help of additional laboratory tests. At the centre was a suicide letter which was hidden in a very unusual way and which was elucidated only thanks to autopsy of both persons. The manner of realisation - hanging - was among the most frequent in the region and in the state too. The men were not under the influence of any toxic substances. The motivation behind the suicide was an escape from hard living conditions.
Asunto(s)
Motivación , Suicidio/psicología , Asfixia , Autopsia , Familia , Padre , HumanosRESUMEN
According to Slovak legislation any individual consuming ethanol may, under certain conditions, face substantial legal consequences. It is generally known that results of almost any breath alcohol test may be challenged by an experienced defense attorney using scientific principles of these tests. Most common of these legal attacks on breath alcohol test are presented. Lack of attention to this matter from medico-legal societies in Slovak and Czech Republic is also pointed out.
Asunto(s)
Intoxicación Alcohólica/diagnóstico , Pruebas Respiratorias , República Checa , Humanos , EslovaquiaRESUMEN
The aim of our study was to verify possible utilization of RT-PCR method (Reverse Transcriptase-Polymerase Chain Reaction) as a diagnostic and prognostic modality of the progression of prostate cancer. This approach is commonly used for the detection of circulating carcinomatous cells in peripheral blood of patients with malignant breast tumors, and our ambition was to adopt this method for patients with prostate cancer. The contribution of this method consists in its ability to detect early stages of the dispersion of carcinomatous cells, so called micrometastases, in the peripheral circulation of patients. The estimation of the progression of the disease is especially important for the selection of appropriate therapy for individual patients. Using this method we analyzed 50 men: 28 patients with clinically localized or locally advanced prostate cancer, 7 patients with clinically proven metastases, 8 patients with benign prostatic hyperplasia, and 7 healthy young men.
Asunto(s)
Células Neoplásicas Circulantes , Neoplasias de la Próstata/sangre , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Anciano , Progresión de la Enfermedad , Humanos , Masculino , Persona de Mediana Edad , Hiperplasia Prostática/sangre , Neoplasias de la Próstata/patología , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa/métodosRESUMEN
The study of molecular markers in various types of human carcinomas, as well as in carcinoma of prostate, is focused on genes responsible for the formation of carcinoma. Mutation, amplification or other changes in these genes or in their protein products are being examined and compared with traditional prognostic markers. These genes can be characterized as oncogenes, tumor suppressor genes or genes for other significant cell functions. However, studies are often limited by heterogenity and multifocality of tumors, especially in prostate cancer. In this review, we offer a survey of some of the most frequent diagnostic and prognostic parameters of molecular biology research in relation to prostate cancer.
Asunto(s)
Biomarcadores de Tumor/análisis , Marcadores Genéticos , Neoplasias de la Próstata/diagnóstico , Genes Supresores de Tumor , Humanos , Masculino , Oncogenes , Antígeno Prostático Específico/sangre , Neoplasias de la Próstata/genética , Reacción en Cadena de la Polimerasa de Transcriptasa InversaRESUMEN
During assessment of the progression of several types of carcinomas, such as cancer of the breast, lungs, prostate or urinary bladder world-wide the presence of circulating cells (micrometastases) in the circulation is followed up. These methods are gradually introduced also in Slovakia. First we tried in the Institute of Medical Biology and Genetics Medical Faculty Comenius University in collaboration with the Urological Clinic of Dérers the Faculty Hospital with policlinic to apply this method in carcinoma of the prostate (CaP). We detected the presence of epithelial prostate cells in the peripheral blood stream of patients with advanced prostate cancer where before secondaries were not detected.