The role of molecular biology in detection and monitoring of prostate cancer.

Zummerová, A; Böhmer, D; Fillo, J; Danihel, L; Repiská, V

Zummerová, A; Böhmer, D; Fillo, J; Danihel, L; Repiská, V.

Afiliación

Zummerová A; Department of Pathology and Forensic Medicine, Health Care Surveillance Authority, Bratislava, Slovakia. anezkazummerova@yahoo.com

Cesk Patol ; 46(4): 95-7, 2010 Oct.

Article en En | MEDLINE | ID: mdl-21309265

RESUMEN

The study of molecular markers in various types of human carcinomas, as well as in carcinoma of prostate, is focused on genes responsible for the formation of carcinoma. Mutation, amplification or other changes in these genes or in their protein products are being examined and compared with traditional prognostic markers. These genes can be characterized as oncogenes, tumor suppressor genes or genes for other significant cell functions. However, studies are often limited by heterogenity and multifocality of tumors, especially in prostate cancer. In this review, we offer a survey of some of the most frequent diagnostic and prognostic parameters of molecular biology research in relation to prostate cancer.

Asunto(s)

Biomarcadores de Tumor/análisis; Marcadores Genéticos; Neoplasias de la Próstata/diagnóstico; Genes Supresores de Tumor; Humanos; Masculino; Oncogenes; Antígeno Prostático Específico/sangre; Neoplasias de la Próstata/genética; Reacción en Cadena de la Polimerasa de Transcriptasa Inversa

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Próstata / Biomarcadores de Tumor / Marcadores Genéticos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans / Male Idioma: En Revista: Cesk Patol Año: 2010 Tipo del documento: Article País de afiliación: Eslovaquia Pais de publicación: República Checa

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