RESUMEN

The contractile action of bradykinin on isolated smooth muscles is known to be potentiated by special peptides isolated from snake venoms and other animal sources. A fraction F (AppF) has been derived from Agkistrodon piscivorus piscivorus venom. This fraction does not increase the depressor effect of bradykinin n blood pressure, potentiates the action of bradykinin on isolated guinea-pig ileum and prolongs the duration of relaxation in isolated rat duodenum. This fraction was able to inhibit the conversion of angiotensin I to angiotensin II in vitro. The primary structure of this decapeptide is given.

Asunto(s)

Presión Sanguínea/efectos de los fármacos , Venenos de Crotálidos/química , Músculo Liso/efectos de los fármacos , Oligopéptidos/farmacología , Fragmentos de Péptidos/farmacología , Angiotensina I/metabolismo , Angiotensina II/metabolismo , Inhibidores de la Enzima Convertidora de Angiotensina/farmacología , Animales , Bradiquinina/metabolismo , Bradiquinina/farmacología , Sinergismo Farmacológico , Cobayas , Espectrometría de Masas , Oligopéptidos/química , Oligopéptidos/aislamiento & purificación , Fragmentos de Péptidos/química , Fragmentos de Péptidos/aislamiento & purificación , Ratas