RESUMEN
Migraine has been reported as a risk factor for ischemic stroke or cardiovascular events, and dysfunction of endothelial cells has been evidenced in migraine patients. Proangiogenic factors are potential endothelial stimulators, and their disturbances can link abnormalities of endothelium with increased risk of vascular disorders. The aim of this study was to evaluate the levels of circulating proangiogenic factors in sera of migraineurs during interictal period. Fifty-two patients aged 37.9 ± 9.6 years, fulfilling International Headache Society criteria for migraine, were included in this observational case-control study. The control group included 39 healthy volunteers, matched according to age and gender. All subjects underwent full neurological examination and clinimetric evaluation with the use of: MIDAS, MIGSEV, QVM, VAS and VRS scales. Serum concentrations of vascular endothelial growth factor (VEGF), angiogenin, angiopoietin-2, thrombopoietin and Tie-2 were estimated in migraineurs and in the control group with the use of ELISA. In migraineurs during interictal period, we have found decreased serum VEGF and angiogenin concentrations compared with controls. Age of migraine onset correlated with VEGF, angiopoietin-2 and thrombopoietin concentrations. Furthermore, angiopoietin-2 level correlated with QVM score and Tie-2 with pain intensity evaluated using MIGSEV scale. In migraine patients during interictal period, depletion of VEGF and angiogenin, two cooperating proangiogenic factors, can be responsible for endothelial dysfunction and increased risk for vascular disorders.
Asunto(s)
Angiopoyetina 2/sangre , Trastornos Migrañosos/sangre , Receptor TIE-2/sangre , Ribonucleasa Pancreática/sangre , Trombopoyetina/sangre , Factor A de Crecimiento Endotelial Vascular/sangre , Adulto , Isquemia Encefálica/etiología , Estudios de Casos y Controles , Endotelio Vascular/fisiopatología , Predisposición Genética a la Enfermedad , Humanos , Lípidos/sangre , Persona de Mediana Edad , Trastornos Migrañosos/complicaciones , Índice de Severidad de la EnfermedadRESUMEN
The aim of the present study was to investigate the levels of circulating CD14 in relation to the expression of tumor necrosis factor alpha (TNF-α) in monocytes, and serum levels of TNF-α and macrophage inflammatory protein-1 (MIP-1) in migraine patients. Numerous studies revealed controversial changes in the components of the immune system during attacks and the interictal period in migraine patients. Our study included 40 migraineurs and 39 controls. The levels of TNF-α, MIP-1 and CD14 were measured in peripheral monocytes and in sera with the Enzyme-Linked Immunosorbent Assay (ELISA) method, and the monocyte expression of TNF-α was also analysed by immunostaining. Serum CD14 concentrations were higher and the expression of TNF-α in monocytes was decreased in migraineurs. The serum MIP-1 level correlated with Verbal Rating Scale (VRS); the MIP-1:CD14 ratio in monocytes correlated with Visual Analogue Scale (VAS); the MIP-1:CD14 ratio correlated with Migraine Severity (MIGSEV)-Pain scores; and serum CD14 concentration correlated with migraine duration in years. Increased serum CD14 and depletion of TNF-α in monocytes can orchestrate other components of the immune system during the interictal period.
Asunto(s)
Receptores de Lipopolisacáridos/sangre , Trastornos Migrañosos/metabolismo , Monocitos/metabolismo , Factor de Necrosis Tumoral alfa/metabolismo , Adulto , Biomarcadores , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trastornos Migrañosos/diagnóstico , Trastornos Migrañosos/etiología , Índice de Severidad de la Enfermedad , Factor de Necrosis Tumoral alfa/sangreRESUMEN
This article is focusing on the etiology of the multiple sclerosis (MS). MS is the disease of autoimmune origin, concerning mainly young people with its complicated nature. The course of the degenerative and inflammatory process is variable and unexpected, from featureless to the vast and rapidly progressing nature, leading to the considerable disability. The etiological factors are not still well known. We can distinguish different agents: genetic, immunological and environmental, among them tobacco smoking also. Authors survey the etiopathological basis of the disease.
Asunto(s)
Esclerosis Múltiple/epidemiología , Fumar/epidemiología , Tabaquismo/epidemiología , Adyuvantes Inmunológicos , Adulto , Autoinmunidad/inmunología , Causalidad , Enfermedad Crónica , Comorbilidad , Citocinas/inmunología , Femenino , Humanos , Masculino , Esclerosis Múltiple/inmunología , Proteína Básica de Mielina/inmunología , Linfocitos T/inmunología , Tabaquismo/inmunologíaRESUMEN
Muliple sclerosis (MS) is a chronic disorder of autoimmune origin, affecting young people. The aim of our study was to evaluate the tobacco smoking in the patients with MS in the period of beginning the disease. The study included 58 MS patients (31 females, 27 males, mean +/- SD: age 32.15 +/- 6.28) with varying degrees of severity and types of MS (A. RRMS relapsing- remitting MS, B. SPMS - secondary-progressive MS and C. PPMS primary - progressive MS). Smoking status was determined by medical history and Fagerström test. In the examined group 38 (65.51%) persons were tobacco smokers, among them 21 (55.26%) females and 17 (44.74%) males. This preliminary analysis needs further thorough studies, f.e. the urine level of cotinine - as a main marker of tobacco smoking in MS patients.
Asunto(s)
Esclerosis Múltiple/epidemiología , Fumar/epidemiología , Tabaquismo/epidemiología , Adulto , Enfermedad Crónica , Cotinina/orina , Femenino , Humanos , Masculino , Esclerosis Múltiple/orina , Prevalencia , Índice de Severidad de la EnfermedadRESUMEN
Moyamoya disease is a chronic non-inflammatory cerebrovascular steno-occlusive disorder of unknown origin, with a typical pattern of collateral netlike vessels visualized in angiography. In Poland it is a relatively rare condition. A case of a 44-year-old non-Japanese woman with moyamoya disease is presented. Ischemic manifestation of the disease, rather uncommon in adults, and a long asymptomatic post-operative period are discussed.