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Increased Serum CD14 Level Is Associated with Depletion of TNF-α in Monocytes in Migraine Patients during Interictal Period.
Michalak, Slawomir; Kalinowska-Lyszczarz, Alicja; Wegrzyn, Danuta; Niezgoda, Adam; Losy, Jacek; Osztynowicz, Krystyna; Kozubski, Wojciech.
Afiliación
  • Michalak S; Department of Neurochemistry and Neuropathology, Chair of Neurology, Poznan University of Medical Sciences (PUMS), Poznan 60-355, Poland. slamic@yahoo.com.
  • Kalinowska-Lyszczarz A; Department of Neurochemistry and Neuropathology, Chair of Neurology, Poznan University of Medical Sciences (PUMS), Poznan 60-355, Poland.
  • Wegrzyn D; Chair of Neurology, PUMS, Poznan 60-355, Poland. neurosk@ump.edu.pl.
  • Niezgoda A; Chair of Neurology, PUMS, Poznan 60-355, Poland. adamniezgoda@wp.pl.
  • Losy J; Department of Clinical Neuroimmunology, Chair of Neurology, PUMS, Poznan 60-355, Poland. jlosy@ump.edu.pl.
  • Osztynowicz K; Department of Neurochemistry and Neuropathology, Chair of Neurology, Poznan University of Medical Sciences (PUMS), Poznan 60-355, Poland. osztynowiczkr@ump.edu.pl.
  • Kozubski W; Chair of Neurology, PUMS, Poznan 60-355, Poland. wkozubski@ump.edu.pl.
Int J Mol Sci ; 18(2)2017 Feb 13.
Article en En | MEDLINE | ID: mdl-28208835
The aim of the present study was to investigate the levels of circulating CD14 in relation to the expression of tumor necrosis factor alpha (TNF-α) in monocytes, and serum levels of TNF-α and macrophage inflammatory protein-1 (MIP-1) in migraine patients. Numerous studies revealed controversial changes in the components of the immune system during attacks and the interictal period in migraine patients. Our study included 40 migraineurs and 39 controls. The levels of TNF-α, MIP-1 and CD14 were measured in peripheral monocytes and in sera with the Enzyme-Linked Immunosorbent Assay (ELISA) method, and the monocyte expression of TNF-α was also analysed by immunostaining. Serum CD14 concentrations were higher and the expression of TNF-α in monocytes was decreased in migraineurs. The serum MIP-1 level correlated with Verbal Rating Scale (VRS); the MIP-1:CD14 ratio in monocytes correlated with Visual Analogue Scale (VAS); the MIP-1:CD14 ratio correlated with Migraine Severity (MIGSEV)-Pain scores; and serum CD14 concentration correlated with migraine duration in years. Increased serum CD14 and depletion of TNF-α in monocytes can orchestrate other components of the immune system during the interictal period.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monocitos / Factor de Necrosis Tumoral alfa / Receptores de Lipopolisacáridos / Trastornos Migrañosos Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Monocitos / Factor de Necrosis Tumoral alfa / Receptores de Lipopolisacáridos / Trastornos Migrañosos Tipo de estudio: Diagnostic_studies / Etiology_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Mol Sci Año: 2017 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Suiza