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PURPOSE: To explore data availability, perceived relevance, acceptability and feasibility of implementing 52 draft indicators for adolescent health measurement in different countries globally. METHODS: A mixed-methods, sequential explanatory study was conducted in 12 countries. An online spreadsheet was used to assess data availability and a stakeholder survey to assess perceived relevance, acceptability, and feasibility of implementing each draft indicator proposed by the Global Action for Measurement of Adolescent health (GAMA). The assessments were discussed in virtual meetings with all countries and in deep dives with three countries. Findings were synthesized using descriptive statistics and qualitative thematic analysis. RESULTS: Data availability varied across the 52 draft GAMA indicators and across countries. Nine countries reported measuring over half of the indicators. Most indicators were rated relevant by stakeholders, while some were considered less acceptable and feasible. The ten lowest-ranking indicators were related to mental health, sexual health and substance use; the highest-ranking indicators centered on broader adolescent health issues, like use of health services. Indicators with higher data availability and alignment with national priorities were generally considered most relevant, acceptable and feasible. Barriers to measurement included legal, ethical and sensitivity issues, challenges with multi-sectoral coordination and data systems flexibility. DISCUSSION: Most of the draft GAMA indicators were deemed relevant and feasible, but contextual priorities and perceived acceptability influenced their implementation in countries. To increase their use for a more comprehensive understanding of adolescent health, better multi-sectoral coordination and tailored capacity building to accommodate the diverse data systems in countries will be required.

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Resumen Objetivo: presentar los aprendizajes de una sistematización como método, para la construcción de conocimiento basado en la experiencia vivida por los propios investigadores de varios proyectos sobre la educación en crianza, en el campo de la salud pública, llevado a cabo en la vereda Granizal, Antioquia, durante el período 2013-2019. Materiales y método: se empleó la sistematización de experiencias y los participantes fueron los mismos investigadores. Se inició con la organización de los materiales, los diarios de campo de los círculos de investigación temática y relatorías de las reuniones del equipo de investigación y de los actores comunitarios. Se siguió con la elaboración de una matriz con la recuperación histórica. Y, finalmente, de las reflexiones grupales, surgieron categorías y relaciones para la construcción teórica de visión de conjunto. Resultados: se presenta la propuesta teórica de la sistematización y los procedimientos para implementarla, orientada por cinco momentos: vivir la experiencia, formular un plan de sistematización, recuperar el proceso vivido, las reflexiones de fondo y los puntos de llegada. Se destacan cuatro rasgos de la sistematización: una investigación creativa; basada en un proceso de construcción colectiva; para aprender de la práctica y construir conocimiento; y como escenario transformador de esta y de quienes la realizaron. Conclusión: la "sistematización de la sistematización" permitió hacer conciencia sobre la propia praxis investigativa. Muestra la comprensión del grupo acerca de la conceptualización y metodología de esta perspectiva investigativa. Trasciende la recopilación y organización de la información del proceso vivido en la medida en que la reconstrucción de la experiencia es una comprensión más amplia que transforma la práctica de los sujetos involucrados.

Abstract Objective: to present the learning of a systematization as a method, for the construction of knowledge based on the experience lived by the researchers of several projects on parenting education in the field of public health carried out in the rural settlement of Granizal, Antioquia, during the period 2013-2019. Materials and method: the systematization of experiences was used and the participants were the researchers. It began with the organization of the materials, the field diaries of the thematic research circles and reports of the meetings of the research team and community actors. It was continued with the elaboration of a matrix with the historical recovery. And, finally, reflections, categories and relationships emerged from the group for the theoretical construction of the overall vision. Results: the theoretical proposal of the systematization and the procedures to implement it are presented, guided by five moments: living the experience, formulating a systematization plan, recovering the lived process, the background reflections and the arrival points. Four features of systematization stand out: creative research; research based on a process of collective construction; learning from practice and building knowledge; and as a transforming scenario of this research and of those who carried it out. Conclusion: the "systematization of the systematization" allowed raising awareness of the research praxis itself. It shows the understanding of the group on conceptualization and methodology of this research perspective. It transcends the collection and organization of the information of the process lived to the extent that the reconstruction of the experience is a broader understanding that transforms the practice of the subjects involved.

Resumo Objetivo: apresentar as aprendizagens de uma sistematização como método, para a construção de conhecimento baseado na experiência vivida pelos próprios pesquisadores de vários projetos sobre a educação em criação, no campo da saúde pública, levado a cabo no povoado Granizal, Antioquia, durante o período 2013-2019. Materiais e método: utilizou-se a sistematização de experiências os participantes foram os mesmos pesquisadores. Iniciou-se com a organização dos materiais, os diários de campo dos círculos de pesquisa temática e relatorias das reuniões da equipe de pesquisa e dos atores comunitários. Conseguiu-se com a elaboração de uma matriz com a recuperação histórica. E, finalmente, das reflexões grupais, surgiram categorias e relações para a construção teórica de visão de conjunto. Resultados: apresenta-se a proposta teórica da sistematização e os procedimentos para implementá-la, orientada por cinco momentos: viver a experiência, formular um plano de sistematização, recuperar os processos vividos, as reflexões de fundo e os pontos de chegada. Destacam-se quatro rasgos da sistematização: uma pesquisa criativa; baseada em um processo de construção coletiva; para aprender da prática e construir conhecimento; e como cenário transformador desta e de quem a realizaram. Conclusão: a "sistematização da sistematização" permitiu fazer consciência sobre a própria práxis pesquisaria. Amostra a compreensão do grupo acerca da conceptualização e metodologia desta perspectiva pesquisaria. Trascende a recopilação e organização da informação do processo vivido na medida em que a reconstrução da experiência é uma compreensão mais ampla que transforma a prática dos sujeitos envolvidos.

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Resumen Cuando los procesos de construcción de contenidos digitales se producen con escaza participación de la comunidad, las decisiones sobre el significado pasan por la interpretación de técnicos y profesionales expertos que tienen otra lectura del mundo y en algunos casos se termina en procesos de exclusión desde el mismo significado que se presenta. Debido a la toma de decisiones que surge entre una temática y el modo que se elige, se presenta como reto una participación amplia de las comunidades para crear contenidos formativos en el marco de la Educativos para la Salud (EpS).

Abstract: When the processes of construction of digital contents are produced with little participation of community, decisions about the meaning go through the interpretation of technical and professional experts, who have another reading of the world and, in some cases, end up in processes of exclusion from the same meaning that is presented. Due to the decision making that arises between a theme and the way it is chosen, a broad participation of communities to create formative contents within the framework of Education for Health (EpS) is presented as a challenge.

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Using a four-wave/seven-month longitudinal design with a sample of 1595 preadolescents (53% boys, 47% girls, Mage = 10.2 years) from 63 fourth-, fifth- and sixth- grade classrooms in nine mixed-sex schools in Bogotá, Colombia, we examined whether growth trajectories of measures of overt and relational aggression varied as a function of classroom norms for aggression. Multilevel growth mixture modeling revealed (a) distinct trajectories of overt and relational aggression for boys and girls and (b) that norm salience (i.e., the process by which a group norm is made salient via the punishments or reinforcements to the behavior within the group) was a better predictor of associations with trajectories of overt and relational aggression than were perceived injunctive norms (i.e., the perceived standards of what is approved or disapproved in a social context). In classrooms where popular or accepted children were perceived by their peers as aggressive, more boys followed an increasing trajectory of overt and relational aggression than a low-stable trajectory, and more girls followed a high-stable trajectory of relational aggression than a low-stable trajectory. These findings are discussed in terms of the practical implications for the design of educational interventions aimed at preventing aggression in classroom settings.

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Samples were collected for several weeks to determine the evolution of the 131I (Iodine-131) activity concentration in the inflow water processed at the Salitre wastewater treatment plant (WWTP) in Bogota, Colombia, derived from medical facilities for thyroid cancer diagnosis and treatment. Mass balances on 131I were performed based on the activity rates at the main inflow and outflow of the plant. The 131I activity concentration in the raw water stream was observed to increase significantly from Monday onwards throughout the week, while the daily activity concentration was highest in the morning and then continuously decreased over the rest of the day. The 131I activity concentration in the raw water exceeds the reference value for drinking water and is very close to the discharge limit in water bodies in Colombia. A mass balance calculation showed that the activity rate for the inflow and outflow waters of the WWTP is about 15% of the authorized activity to use for facilities discharging water into the basins and the use of bio-sludge stream for organic fertilizer production does not represent a significant risk of external irradiation for the population. The results of this work are the first of its kind in Colombia, which ones contribute significantly to determinate the radiological risk to public health due to utilization of treated water and sludge, know the 131I behavior in the city sewage systems, and give information for the performance review of regulatory control on 131I management in the country.

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This work presents a stochastic procedure designed to formulate a discrete set of molecular structures that, as a whole, adjust properly to experimental asphaltene data. This algorithm incorporates the pentane effect concept and Clar's sextet rule to the formulation process. The set of viable structures was constructed based on probability distribution functions obtained from experimental information and an isomer database containing all plausible configurations for a given number of rings, avoiding high-energy structures. This procedure was applied to a collection of experimental data from the literature. Ten sets, consisting of 5000 structures each, were obtained. Each set was then optimized. For the most accurate representation, four molecules were sufficient to properly reproduce the experimental input. The asphaltene system obtained is consistent with the reported molecular weight, number of aromatic rings and heteroatom content. Molecular dynamic simulations showed that the asphaltene representation adequately reproduced asphaltene aggregation behavior in toluene and n-heptane. In toluene, a single three-molecule aggregate was observed, and the majority of asphaltene molecules remained in a monomeric state. In n-heptane, aggregates containing up to four molecules were observed; both porous and compact aggregates were found. The asphaltene molecular representation obtained, which allows researchers to avoid inappropriate torsions in the molecule, is able to reproduce interplanar distances between aromatic cores of 4 Å or less for the aggregation state, as supported by experimental results.

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Classrooms in Peace (Aulas en Paz) is an elementary school-based multicomponent program for prevention of aggression and promotion of peaceful relationships. Inspired by international programs and socio-emotional research, it includes (1) a classroom universal curriculum, (2) parent workshops and home visits to parents of the 10% most aggressive children, and (3) extracurricular peer groups of two aggressive and four prosocial children. Activities seek to promote socio-emotional competencies such as empathy, anger management, creative generation of alternatives, and assertiveness. A 2-year quasi-experimental evaluation was conducted with 1154 students from 55 classrooms of seven public schools located in neighborhoods with the presence of youth gangs, drug cartels, and high levels of community violence in two Colombian cities. Despite several implementation (e.g., about half of the activities were not implemented) and evaluation (e.g., randomization problems, large number of missing data, and changes between treatment and control groups) challenges, positive results were found in prosocial behavior and in reduction of aggressive behavior, according to teacher reports, and in assertiveness and reduction of verbal victimization, according to student reports. Furthermore, implementation cost (25 US dollars per student per year) was very low compared to other programs in developed countries. This study shows that the Classrooms in Peace program has an important potential to generate positive results and highlights the challenges of implementing and evaluating prevention programs in highly violent environments.

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Three methods of molecular dynamics simulation [Green-Kubo (G-K), non-equilibrium molecular dynamics (NEMD) and reversed non-equilibrium molecular dynamics (RNEMD)], and two group contribution methods [UNIFAC-VISCO and Grunberg-Nissan (G-N)] were used to calculate the viscosity of mixtures of n-heptane and toluene (known as heptol). The results obtained for the viscosity and density of heptol were compared with reported experimental data, and the advantages and disadvantages of each method are discussed. Overall, the five methods showed good agreement between calculated and experimental viscosities. In all cases, the deviation was lower than 9%. It was found that, as the concentration of toluene increases, the deviation of the density of the mixture (as calculated with molecular dynamics methods) also increases, which directly affects the viscosity result obtained. Among the molecular simulation techniques evaluated here, G-K produced the best results, and represents the optimal balance between quality of result and time required for simulation. The NEMD method produced acceptable results for the viscosity of the system but required more simulation time as well as the determination of an appropriate shear rate. The RNEMD method was fast and eliminated the need to determine a set of values for shear rate, but introduced large fluctuations in measurements of shear rate and viscosity. The two group contribution methods were accurate and fast when used to calculate viscosity, but require knowledge of the viscosity of the pure compounds, which is a serious limitation for applications in complex multicomponent systems.

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BACKGROUND: Anticoagulation of the continuous renal replacement therapy (CRRT) circuit is an important technical aspect of this medical procedure. Most studies evaluating the efficacy and safety of citrate use have been carried out in adults, and little evidence is available for the pediatric patient population. The aim of this study was to compare regional citrate anticoagulation versus systemic heparin anticoagulation in terms of the lifetime of hemofilters in a pediatric population receiving CRRT at a pediatric center in Bogota, Colombia. METHODS: This was an analytical, observational, retrospective cohort study in which we assessed the survival of 150 hemofilters (citrate group 80 hemofilters, heparin group 70 hemofilters) used in a total of 3442 hours of CCRT (citrate group 2248 h, heparin group 1194 h). Hemofilter survival was estimated beginning at placement and continuing until filter replacement due to clotting or high trans-membrane pressures. RESULTS: Hemofilter survival was higher in the citrate group than in the heparin group (72 vs. 18 h; p <0.0001). Bivariate analysis showed that the hemofilter coagulation risk was significantly increased when heparin was used, regardless of hemofilter size and pump flow (hazard ratio 3.70, standard error 0.82, 95% confidence interval 2.39-5.72; p <0.00001). CONCLUSIONS: Regional citrate anticoagulation could be more effective than heparin systemic anticoagulation in terms of prolonging the hemofilter lifetime in patients with acute renal injury who require CRRT.

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In this paper we report a quantitative laser Biospeckle method using VDRL plates to monitor the activity of Trypanosoma cruzi and the calibration conditions including three image processing algorithms and three programs (ImageJ and two programs designed in this work). Benznidazole was used as a test drug. Variable volume (constant density) and variable density (constant volume) were used for the quantitative evaluation of parasite activity in calibrated wells of the VDRL plate. The desiccation process within the well was monitored as a function of volume and of the activity of the Biospeckle pattern of the parasites as well as the quantitative effect of the surface parasite quantity (proportion of the object's plane). A statistical analysis was performed with ANOVA, Tukey post hoc and Descriptive Statistics using R and R Commander. Conditions of volume (100µl) and parasite density (2-4x104 parasites/well, in exponential growth phase), assay time (up to 204min), frame number (11 frames), algorithm and program (RCommander/SAGA) for image processing were selected to test the effect of variable concentrations of benznidazole (0.0195 to 20µg/mL / 0.075 to 76.8µM) at various times (1, 61, 128 and 204min) on the activity of the Biospeckle pattern. The flat wells of the VDRL plate were found to be suitable for the quantitative calibration of the activity of Trypanosoma cruzi using the appropriate algorithm and program. Under these conditions, benznidazole produces at 1min an instantaneous effect on the activity of the Biospeckle pattern of T. cruzi, which remains with a similar profile up to 1 hour. A second effect which is dependent on concentrations above 1.25µg/mL and is statistically different from the effect at lower concentrations causes a decrease in the activity of the Biospeckle pattern. This effect is better detected after 1 hour of drug action. This behavior may be explained by an instantaneous effect on a membrane protein of Trypanosoma cruzi that could mediate the translocation of benznidazole. At longer times the effect may possibly be explained by the required transformation of the pro-drug into the active drug.

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This paper reports on the application of the motion history image (MHI) method on dynamic laser speckle processing as a result of a specific drug action on Trypanosoma cruzi parasites. The MHI procedure is based on human action recognition, and unlike other methods which use a sequence consisting of several frames for recognition, this method uses only an MHI per action sequence for recognition. MHI method avoids the complexity as well as the large computation in sequence matching-based methods and detects a change in the speckle pattern. Experimental results of MHI on real-time monitoring of activity (motility) under the influence of the drug demonstrate the effectiveness of the proposed method. The MHI showed an online result without loss of resolution and definition if we compare with routine LASCA method. The obtained results highlight the advantage of the MHI analysis over traditional qualitative image intensity-based methods and demonstrate the potential of measuring the activity of parasites via dynamic laser speckle analysis. The data was further numerically analyzed in the time domain, and the results presented the ability of the technique to monitor the action of the drug, particularly Epirubicin (100 µg/ml).

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OBJECTIVE: We report on two rare Xq rearrangements, namely a t(X;9)(q24;q12) found in a mildly-affected girl (Patient 1) and a rea(X)dup q concomitant with a rob(14;21)mat in a Down syndrome girl (Patient 2). CASE REPORT: Both rearrangements were characterized by banding techniques [Giemsa (G), constitutive heterochromatin (C), and bromodeoxyuridine (BrdU) pulse], fluorescence in situ hybridization (FISH) assays, human androgen receptor (HUMAR) assays, and microarray analyses. Patient 1 had a t(X;9)(q24;q12)dn. Patient 2 had a de novo rea(X)(qter→q23 or q24::p11.2→qter) concomitant with an unbalanced rob(14;21)mat. X-Inactivation studies in metaphases and DNA revealed a fully skewed inactivation: the normal homolog was silenced in Patient 1 and the rea(X) in Patient 2. Both rearranged X chromosomes were of paternal descent. Microarray analyses revealed no imbalances in Patient 1 whereas loss of Xp (∼52 Mb) and duplication of Xq (∼44 Mb) and 21q were confirmed in Patient 2. CONCLUSION: Our observations further document the cytogenetic heterogeneity and predominant paternal origin of certain de novo X-chromosome rearrangements.

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There is considerable debate over whether cyberbullying is just another form of bullying, or whether it is a problem distinct enough to require specific intervention. One way to explore this issue is to analyze whether programs designed to prevent traditional bullying help prevent cyberbullying, and whether programs designed to prevent cyberbullying prevent traditional bullying. The main goal of the current study was to analyze the spillover effects of the cyberbullying prevention program Media Heroes (Medienhelden) on traditional bullying. Media Heroes promotes empathy, knowledge of risks and consequences, and strategies that allow bystanders to defend victims from cyberbullying. Mixed ANOVAs were conducted comparing pretest and post-test (6 months after intervention) measures of 722 students (ages 11-17) assigned to a long (15 sessions) intervention, a short (1 day) intervention, and a control group. In addition to confirming the previously reported effects on cyberbullying, Media Heroes was found to reduce traditional bullying. Effects were larger for the long-version of the program than for the short 1-day version. No effects were found on victimization by either cyberbullying or traditional bullying. Strategies to complement traditional and cyberbullying prevention efforts are discussed. Aggr. Behav. 42:157-165, 2016. © 2016 Wiley Periodicals, Inc.

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Upon ascending above 2500 meters sea level, the human body undergoes a series of physiological changes that have been studied during years. These changes undertake various systems including gastrointestinal tract, with diverse clinical manifestations, most mild and therefore little reported and are underdiagnosed. Two pediatric patients who atended to the Pediatric Unit of Gastroenterolog, Hepatolog and Nutrition (Gastronutriped) in Bogota, in whose we documented symptoms affecting gastrointestinal tract associated with high altitude.Regarding to these cases, a review of the available literature focusing on physiolog, clinical manifestations and feasible treatment was made. The final aim of this article is to sensitize to health care professionals working in cities located at high altitudes, to consider this entity as a differential diagnosis in children from places with lower altitude.

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El aceite de pino es una mezcla de monoterpenos, hidrocarburos terpénicos y alcoholes terpénicos cíclicos derivados de la destilación de la madera de pino con aproximadamente un 57% de alfa-pineno como su principal componente. Es un líquido incoloro o ámbar claro con olor característico a pino. Puede mezclarse con alcohol en todas proporciones. El aceite se obtiene por destilación mediante arrastre por vapor de las aguas y de las puntas enteras de las ramitas nuevas. También existen otros métodos de extracción de aceites, se puede utilizar la hidrodestilación para extraer su aceite esencial. Estos aceites son agentes utilizados por su agradable fragancia y además porque poseen acción desinfectante y bactericida. Se usa en la formulación de una gran variedad de productos domésticos de limpieza. También se emplea como humectante, aromatizante o disolvente en la industria textil. En la industria y el comercio se venden aceites de pino que muchas veces no es totalmente puro, es decir este producto está siendo adulterado. Esto puede disminuir la efectividad de sus subproductos. De aquí radica la importancia del estudio de sus propiedades las cuales son muy útiles para la industria. Obtenido una muestra de aceite extraído directamente de la madera de pino y analizando las propiedades de este se podrá saber la diferencia que radica entre el aceite de pino extraído y el aceite de pino comercial.

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Los carcinomas metaplásicos de mama son un grupo heterogéneo de neoplasias malignas poco frecuentes poco diferenciadas; que representan menos del 1% de todos los tumores de mama invasivos, en los que un segmento de células epiteliales ha sufrido metaplasia, son bifásicos, capaces de adoptar un fenotipo variable, con receptores de estrógeno, progesterona, Her2 negativos. Los carcinomas metaplásicos de mama son más frecuentes en mujeres mayores de 55 años. Su pronóstico es peor que los carcinomas convencionales se relaciona con el tamaño tumoral, tipo histológico, y grado de componente mesenquimático. El tratamiento inicial es quirúrgicoy se considera imprescindible el empleo de técnicas de inmunohistoquímica para diagnosticarlos. Presentamos el caso de una paciente joven de 28 años de edad a quiense le realizó en clínica particular, una mastectomía parcial que reportó carcinoma metaplásico, acudiendo a nuestro servicio, donde se le realiza mastectomía radical modificada tipo Madden preservadora de piel.

Metaplastic breast carcinomas are heterogeneous group of malignancies poorly differentiated and rare, representing less than 1% of all invasive breast tumors, in which a segment has undergone metaplasia epithelial cells are biphasic which can take a variable phenotype, with negative estrogen and progestagen receptors Her2 negative. Metaplastic breast carcinomas are more common in women over 55 years, however, most reports ascribed different characteristics to those of infiltrating ductal carcinoma, found larger tumors, high grade, lymphatic glandular less affected with hormone receptor negative. The prognosis is worse than conventional carcinomas is related to tumor size, histological type, type degree of mesenchymal component.The treatment is surgical is considered essential to the use of immunohistochemistry for diagnosis. We report the case of 28 year woman who was held in private clinic, a partial mastectomy reported metaplastic carcinoma, going to our service, which performs modified radical mastectomy Madden type of skin sparing.

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This study assessed the moderating effect of social problem-solving (SPS) in the association between risk factors and peer victimization in a sample of Colombian adolescents. Using structural equation modeling techniques, this study assessed the extent to which changes in victimization varied as a function of the interaction between risk factors and social problem-solving. Results showed that both aggression and avoidance were predictive of initial scores on victimization, but only avoidance was found to predict its change over time. Only a main effect of SPS was found at the beginning of the year; no moderating effects were found. Results are consistent with previous findings by confirming that avoidance and aggression are risk factors for peer victimization.

Este estudio examinó el rol moderador de la habilidad para resolver problemas sociales (SPS) en la asociación entre factores de riesgo y la victimización, en una muestra de adolescentes colombianos. Mediante el uso de técnicas de ecuaciones estructurales se evaluó qué tanto cambió la victimización a lo largo del tiempo, en función de la interacción entre factores de riesgo y la SPS. Los resultados mostraron que la agresión y la evitación son factores de riesgo y predicen puntajes iniciales en la victimización. Sin embargo, únicamente la evitación predijo los cambios de dicha variable en el tiempo. Adicionalmente, se encontró un efecto de la SPS en la victimización al inicio del año escolar, pero no se encontraron efectos moderadores. Los resultados son consistentes con estudios previos en los que se observa que la evitación y la agresión son factores de riesgo en la victimización.

Este estudo examinou o papel moderador da habilidade para resolver problemas sociais (SPS) na associação entre fatores de risco e a vitimização, em uma amostra de adolescentes colombianos. Mediante o uso de técnicas de equações estruturais, avaliou-se quanto a vitimização ao longo do tempo mudou, em função da interação entre fatores de risco e a SPS. Os resultados mostraram que a agressão e a evitação são fatores de risco e predizem pontuações iniciais na vitimização. Contudo, unicamente a evitação prediz as mudanças de dita variável no tempo. Adicionalmente, constatou-se um efeito da SPS na vitimização ao início do ano escolar, mas não se encontraram efeitos moderadores. Os resultados são consistentes com estudos prévios nos quais se observa que a evitação e a agressão são fatores de risco na vitimização.