RESUMEN
We report a 67-year-old woman with small cell carcinoma of the hypopharynx, a very rare entity with few reports. Our treatment consisted of carboplatin (CBDCA) and etoposide (VP-16) in the same way as small cell carcinoma of the lung is treated. This achieved a complete response. Our case suggests that chemotherapy with carboplatin and etoposide is effective for small cell carcinoma of the hypopharynx.
Asunto(s)
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Carboplatino/uso terapéutico , Carcinoma de Células Pequeñas/tratamiento farmacológico , Etopósido/uso terapéutico , Neoplasias Hipofaríngeas/tratamiento farmacológico , Anciano , Carcinoma de Células Pequeñas/diagnóstico , Femenino , Humanos , Neoplasias Hipofaríngeas/diagnóstico , Fotomicrografía , Tomografía Computarizada por Rayos X , Resultado del TratamientoRESUMEN
OBJECTIVE: To evaluate the role of partial laryngectomy to treat glottic cancer after failure of radiation therapy. DESIGN: A 12-year retrospective outcome analysis. SETTING: University referral center. PATIENTS: A total of 19 patients who underwent partial laryngectomy to treat glottic cancer after failure of radiation therapy. RESULTS: The follow-up period in this group ranged from 31 to 144 months. After surgery, a laryngocutaneous fistula was observed in 4 cases, and flap necrosis occurred in 2, but these complications were successfully managed. Maximum phonation time after surgery ranged from 3 to 28 seconds (median phonation time, 10.2 seconds). Of these 19 patients, 3 developed local recurrence. These cases were successfully treated with total laryngectomy. A surgical margin of less than 1 mm was found to be a significant risk factor for local recurrence after partial laryngectomy. CONCLUSIONS: These results indicate that partial laryngectomy is a useful option for the treatment of irradiation failure in the treatment of stage I and stage II vocal cord carcinomas. However, careful follow-up is mandatory for patients with a small surgical margin.
Asunto(s)
Carcinoma de Células Escamosas/fisiopatología , Carcinoma de Células Escamosas/terapia , Glotis/efectos de la radiación , Glotis/cirugía , Neoplasias Laríngeas/fisiopatología , Neoplasias Laríngeas/terapia , Laringectomía/efectos adversos , Recurrencia Local de Neoplasia/fisiopatología , Recurrencia Local de Neoplasia/terapia , Complicaciones Posoperatorias , Adulto , Anciano , Carcinoma de Células Escamosas/mortalidad , Estudios de Seguimiento , Glotis/fisiopatología , Humanos , Neoplasias Laríngeas/mortalidad , Masculino , Persona de Mediana Edad , Recurrencia Local de Neoplasia/mortalidad , Evaluación de Procesos y Resultados en Atención de Salud , Recuperación de la Función/fisiología , Estudios Retrospectivos , Terapia Recuperativa , Tasa de Supervivencia , Factores de Tiempo , Insuficiencia del TratamientoRESUMEN
A 6-year-old boy lost his normally-developed language ability within 2 months after bilateral sudden peripheral deafness. The boy became non-communicative with others, restless with frequent meaningless bursts of shouts (communication skills equivalent to 9-11 months of language development: a rapid breakdown of language). Since conservative methods were ineffective, cochlear implantation was performed. A surprising success was observed: he regained the language retracing the normal developmental stages and caught up with his contemporaries in 2 years. Behavioral improvement paralleled his language development. This case (1) provides insights into the brain function with respect to language acquisition, in relation to the plasticity during the 'critical period' of language learning, (2) reveals the close relationship between language development and behavior, and (3) suggests the predominance of auditory stimulation in learning language.