RESUMEN
The article gives a summary of endothelial signal molecules that take part in homeostasis regulation and age-associated pathology development. Regulation of the endothelium function is realized by the system of signal molecules (NO, NOS, prostacyclin, thrombomodulin, tromboxan, antithrombin, endothelins, fibronectin, Willebrand's factor et al.). The change of their synthesis is the reason for the development of hypertonic disease, atherosclerosis, ischemic heart disease, myocardial infarction and other age-related pathology. The investigation of molecular mechanisms of endothelium functional activity is very important for creating new methods of diagnostics and treatment of cardio-vascular system age-associated pathology.
Asunto(s)
Envejecimiento/metabolismo , Aterosclerosis , Endotelio Vascular/metabolismo , Endotelio Vascular/fisiopatología , Lípidos/fisiología , Anciano , Aterosclerosis/metabolismo , Aterosclerosis/patología , Aterosclerosis/fisiopatología , Endotelio Vascular/patología , Humanos , Transducción de SeñalRESUMEN
Testing of biological age and the speed of aging is one of the main goal of gerontology and predictive medicine. This review summarizes the ability of using buccal epithelium as target of non-invasive investigation of aging diagnostics. Buccal epithelium used for thelomere test and morphological characteristics of its nucleus demonstrate the speed of aging. The electrophysiological investigation of buccal cells nucleus are the markers of biological age of a human. In future it can be possible to use buccal epithelium for immunogistochemical investigation with goal to diagnose cellular senescence.
Asunto(s)
Envejecimiento/fisiología , Senescencia Celular/fisiología , Mucosa Bucal/fisiología , Electrodiagnóstico/métodos , Epitelio/fisiología , HumanosRESUMEN
The expression of signaling molecules MMP2, MMP9, ERBB3, CXCL12, Nkx2.5, CD90 (the markers of remodeling intracellular matrix and cell differentiation) in human buccal epithelium in ageing has been studied. The expression of molecular markers MMP2, MMP9, CD90 end ERBB3 has shown a decrease during ageing, especially in old people compared with persons of mature age. These data have demonstrated, that buccal epithelium may be considered as a perspective object to study the aging processes in organism as a whole (on the decrease of cell for differentiation and remodeling intracellular matrix).