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OBJECTIVES: Surgical bleeding. transfusion rate and cardiovascular complications were analized in patients undergoing chronic treatment with low-doses aspirin and scheduled to unilateral primary knee arthroplasty. PATIENTS AND METHODS: We retrospectively studied 117 patients between 2005 and 2006 scheduled for elective knee replacement that received antiplatelet therapy with aspirin (100mg/day). Aspirin medication was maintained or discontinued preoperatively according to medical criteria. We analyzed the biological, clinical and anesthetic data, blood-saving techniques used, surgical bleeding, allogeneic blood transfusion rate, cardiocirculatory complications (myocardial, cerebral or peripheral ischemia), hospital stay and mortality. This population was compared with 190 patients (control group) who underwent the same operation at the same time interval but did not receive aspirin therapy. RESULTS: The aspirin-treated group was significantly older, with higher weight and poorer health state (higher incidence of ischemic heart disease, cerebral ischemia and diabetes). The hidden and external surgical bleeding and transfusion rate were similar if the aspirin were interrupted or not, preoperatively. Bleeding and transfusion rates were independent of time of interruption of the aspirin. Hospital mortality was zero in the 2 groups. A acute myocardial infarction and a transient stroke happened in two patients wich aspirin treatment was discontinued. CONCLUSIONS: Preoperative treatment with low doses of aspirin does not increase surgical bleeding and transfusion rate in total knee arthroplasty. Preoperative discontinuation can cause severe cardiocirculatory complications.

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Objetivos. Analizar la hemorragia quirúrgica, índice transfusional y complicaciones cardiovasculares en pacientes en tratamiento crónico con aspirina y sometidos a artroplastia total primaria unilateral de rodilla. Pacientes y métodos. Se estudió retrospectivamente a 117 pacientes programados entre 2005 y 2006 para cirugía electiva de artroplastia de rodilla y en tratamiento preoperatorio con aspirina (100mg/día). La medicación fue mantenida o interrumpida preoperatoriamente a criterio médico. Se analizaron las características biológicas, clínicas, anestésicas, técnicas de ahorro de sangre, hemorragia quirúrgica, transfusión alogénica, complicaciones cardiocirculatorias (isquemia miocárdica, cerebral o periférica), estancia y mortalidad hospitalarias. Se compararon con 190 pacientes (grupo control) intervenidos de la misma operación en el mismo intervalo de tiempo, pero sin tratamiento crónico con aspirina. Resultados. El grupo tratado con aspirina era significativamente de mayor edad, peso y con más enfermedades asociadas (mayor incidencia de cardiopatía isquémica, isquemia cerebral y diabetes). La hemorragia quirúrgica externa, oculta y total fue similar en ambos grupos, así como la transfusión alogénica. La hemorragia y tasa transfusional fueron independientes del tiempo de interrupción de la aspirina. La mortalidad hospitalaria fue nula en los 2 grupos. Dos pacientes en los que se interrumpió el tratamiento tuvieron un infarto agudo de miocardio y un accidente vascular cerebral transitorio, respectivamente. Conclusiones. El tratamiento preoperatorio con aspirina no incrementa la hemorragia quirúrgica ni el índice transfusional en la artroplastia total de rodilla. La interrupción preoperatoria puede ocasionar complicaciones cardiocirculatorias graves(AU)

Objectives. Surgical bleeding. transfusion rate and cardiovascular complications were analized in patients undergoing chronic treatment with low-doses aspirin and scheduled to unilateral primary knee arthroplasty. Patients and methods. We retrospectively studied 117 patients between 2005 and 2006 scheduled for elective knee replacement that received antiplatelet therapy with aspirin (100mg/day). Aspirin medication was maintained or discontinued preoperatively according to medical criteria. We analyzed the biological, clinical and anesthetic data, blood-saving techniques used, surgical bleeding, allogeneic blood transfusion rate, cardiocirculatory complications (myocardial, cerebral or peripheral ischemia), hospital stay and mortality. This population was compared with 190 patients (control group) who underwent the same operation at the same time interval but did not receive aspirin therapy. Results. The aspirin-treated group was significantly older, with higher weight and poorer health state (higher incidence of ischemic heart disease, cerebral ischemia and diabetes). The hidden and external surgical bleeding and transfusion rate were similar if the aspirin were interrupted or not, preoperatively. Bleeding and transfusion rates were independent of time of interruption of the aspirin. Hospital mortality was zero in the 2 groups. A acute myocardial infarction and a transient stroke happened in two patients wich aspirin treatment was discontinued. Conclusions. Preoperative treatment with low doses of aspirin does not increase surgical bleeding and transfusion rate in total knee arthroplasty. Preoperative discontinuation can cause severe cardiocirculatory complications(AU)

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OBJECTIVE: Pain after total knee replacement surgery is intense. The aim of this study was to compare 3 techniques for providing postoperative analgesia (epidural analgesia, femoral nerve block, and a combined femoral-sciatic nerve block) in total knee arthroplasty. MATERIAL AND METHODS: Observational study of 1550 elective primary unilateral total knee replacement operations. The safety and efficacy of the following 3 techniques were compared: epidural analgesia, femoral nerve block, and femoral-sciatic nerve block. Demographic, anesthetic, and surgical data were recorded. Study variables included pain intensity on a visual analog scale every 4 hours, need for rescue analgesia (morphine), complications and adverse events within 5 postoperative days. RESULTS: No significant differences were found in demographic, anesthetic, or surgical variables. In the first 24 hours after surgery, pain intensity was significantly less for patients who received a femoral-sciatic nerve block. The mean levels of morphine consumption in the first 96 hours after surgery were similar in the femoral-sciatic nerve block group (3.18 mg) and the epidural analgesia group (3.19 mg); morphine consumption in the femoral block group was significantly higher (4.51 mg). Epidural analgesia was associated with the highest rate of complications (17%). CONCLUSIONS: A sciatic nerve block combined with a femoral nerve block attenuates pain more effectively and is associated with less postoperative morphine consumption in comparison with a femoral nerve block alone. Peripheral nerve block techniques have fewer adverse side effects than epidural analgesia.

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OBJETIVOS: El dolor postoperatorio de la prótesis totalde rodilla es de una gran intensidad. El objetivo fuecomparar tres técnicas de analgesia postoperatoria (epidural,bloqueo del nervio femoral y bloqueo de los nerviosfemoral y ciático combinados) después de intervenciónde prótesis total de rodilla.MATERIAL Y MÉTODOS: Estudio observacional de 1.550intervenciones de prótesis de rodilla unilateral primariaselectivas. Se compararon tres técnicas de analgesia postoperatoria(epidural, bloqueo femoral y bloqueo femoralciático)para valorar eficacia y seguridad. Se recogierondatos demográficos, anestésicos y quirúrgicos, intensidaddel dolor según escala visual analógica cada 4 horas,rescate analgésico con morfina, complicaciones e incidenciasdurante los 5 primeros días del postoperatorio.RESULTADOS: No hallamos diferencias en las variablesdemográficas, anestésicas y quirúrgicas. La intensidad deldolor fue significativamente menor en el grupo bloqueofemoral y ciático respecto a los grupos epidural y bloqueofemoral durante las primeras 24 horas del postoperatorio.El consumo medio de morfina a las 96 horas tras la intervenciónfue similar en el grupo con bloqueo femoral y ciático(3,18 mg) y epidural (3,19 mg), y significativamentemayor con el bloqueo femoral (4,51 mg). La analgesia epiduralpresento el mayor índice de complicaciones (17%).CONCLUSIONES: Asociar un bloqueo ciático al bloqueofemoral disminuye el dolor y el consumo de morfina postoperatoriorespecto al bloqueo femoral aislado. Las técnicasanalgésicas de bloqueo periférico presentan menosefectos indeseables que la analgesia epidural (AU)

OBJECTIVE: Pain after total knee replacement surgeryis intense. The aim of this study was to compare 3techniques for providing postoperative analgesia(epidural analgesia, femoral nerve block, and acombined femoral-sciatic nerve block) in total kneearthroplasty.MATERIAL AND METHODS: Observational study of 1550elective primary unilateral total knee replacementoperations. The safety and efficacy of the following 3techniques were compared: epidural analgesia, femoralnerve block, and femoral-sciatic nerve block.Demographic, anesthetic, and surgical data wererecorded. Study variables included pain intensity on avisual analog scale every 4 hours, need for rescueanalgesia (morphine), complications and adverse eventswithin 5 postoperative days.RESULTS: No significant differences were found indemographic, anesthetic, or surgical variables. In thefirst 24 hours after surgery, pain intensity wassignificantly less for patients who received a femoralsciaticnerve block. The mean levels of morphineconsumption in the first 96 hours after surgery weresimilar in the femoral-sciatic nerve block group(3.18 mg) and the epidural analgesia group (3.19 mg);morphine consumption in the femoral block group wassignificantly higher (4.51 mg). Epidural analgesia wasassociated with the highest rate of complications (17%).CONCLUSIONS: A sciatic nerve block combined with afemoral nerve block attenuates pain more effectively andis associated with less postoperative morphineconsumption in comparison with a femoral nerve blockalone. Peripheral nerve block techniques have feweradverse side effects than epidural analgesia (AU)

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