RESUMEN
Boron (B) and phosphorus (P) codoped silicon quantum dots (Si QDs) are dispersible in polar solvents without organic ligands and exhibit photoluminescence (PL) in the first (NIR-I) and second (NIR-II) near infrared (NIR) windows in biological tissues due to the optical transition from the donor to acceptor states. We studied the relationship between the PL wavelength, lifetime and quantum yield (QY) of the colloidal solution and the composition of the starting material for the preparation. We found that the PL lifetime and the QY are primarily determined by the composition, while the PL wavelength is mainly determined by the growth temperature. By optimizing the composition, we achieved QYs of 20.1% and 1.74% in the NIR-I and NIR-II regions, respectively, in methanol. We demonstrate the application for time-gated imaging in the NIR-II range.
RESUMEN
We successfully visualize a core-shell structure of a heavily B and P codoped Si quantum dot (QD) by transmission electron microscopy using an ultra-thin graphene oxide support film. The enhanced contrast reveals that a codoped Si QD has a highly crystalline Si core and an amorphous shell composed of Si, B and P.
RESUMEN
A new class of Aurora A kinase inhibitor was created by transforming 4-(5-methyl-3-pyrazoloamino)pyrimidine moiety of VX-680 to 3-cyano-6-(5-methyl-3pyrazoloamino)pyridine. Compound 6 exhibited a potent Aurora A kinase inhibitory activity, excellent selectivity to Aurora B kinase and other 60 kinases, good cell permeability and good PK profile. Therefore compound 6 was effective in antitumor mice model at a dose of 30 mg/kg po qd without decrease of body weight.