RESUMEN
Bacterial cellulose (BC) is a promising natural polymer prized for its biocompatibility, microporosity, transparency, conformability, elasticity, and ability to maintain a moist wound environment while absorbing exudates. These attributes make BC an attractive material in biomedical applications, particularly in skin tissue repair. However, its lack of inherent antimicrobial activity limits its effectiveness. In this study, BC was enhanced by incorporating cerium (IV)-oxide (CeO2) nanoparticles, resulting in a series of bacterial cellulose-CeO2 (BC-CeO2) composite materials. Characterization via FESEM, XRD, and FTIR confirmed the successful synthesis of the composites. Notably, BC-CeO2-1 exhibited no cytotoxic or genotoxic effects on peripheral blood lymphocytes, and it additionally protected cells from genotoxic and cytotoxic effects in H2O2-treated cultures. Redox parameters in blood plasma samples displayed concentration and time-dependent trends in PAB and LPP assays. The incorporation of CeO2 nanoparticles also bolstered antimicrobial activity, expanding the potential biomedical applications of these composites.
Asunto(s)
Antiinfecciosos , Antioxidantes , Celulosa , Cerio , Hidrogeles , Nanopartículas , Cerio/química , Cerio/farmacología , Celulosa/química , Celulosa/farmacología , Antioxidantes/farmacología , Antioxidantes/química , Hidrogeles/química , Hidrogeles/farmacología , Nanopartículas/química , Antiinfecciosos/farmacología , Antiinfecciosos/química , Humanos , Pruebas de Sensibilidad Microbiana , Antibacterianos/farmacología , Antibacterianos/químicaRESUMEN
"Green" strategies to build up novel organic nanocarriers with bioperformance are modern trends in nanotechnology. In this way, the valorization of bio-wastes and the use of living systems to develop multifunctional organic and biogenic nanocarriers (OBNs) have revolutionized the nanotechnological and biomedical fields. This paper is a comprehensive review related to OBNs for bioactives' delivery, providing an overview of the reports on the past two decades. In the first part, several classes of bioactive compounds and their therapeutic role are briefly presented. A broad section is dedicated to the main categories of organic and biogenic nanocarriers. The major challenges regarding the eco-design and the fate of OBNs are suggested to overcome some toxicity-related drawbacks. Future directions and opportunities, and finding "green" solutions for solving the problems related to nanocarriers, are outlined in the final of this paper. We believe that through this review, we will capture the attention of the readers and will open new perspectives for new solutions/ideas for the discovery of more efficient and "green" ways in developing novel bioperformant nanocarriers for transporting bioactive agents.