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Exploring the antimicrobial and antioxidant potential of bacterial cellulose-cerium oxide nanoparticles hydrogel: Design, characterization and biomedical properties.
Butulija, Svetlana; Sobot, Ana Valenta; Todorovic, Bratislav; Petrovic, Sanja M; Radovanovic, Zeljko; Ilic, Bojana; Matovic, Branko; Mihailovic, Ruzica; Zarubica, Aleksandra; Zmejkoski, Danica; Trickovic, Jelena Filipovic.
Afiliación
  • Butulija S; Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11001 Belgrade, Serbia. Electronic address: svetlana8@vin.bg.ac.rs.
  • Sobot AV; Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11001 Belgrade, Serbia. Electronic address: ana_v.s@vin.bg.ac.rs.
  • Todorovic B; Faculty of Technology, University of Nis, Bulevar Oslobodenja 124, Leskovac, Serbia. Electronic address: vinarce2001@yahoo.com.
  • Petrovic SM; Faculty of Technology, University of Nis, Bulevar Oslobodenja 124, Leskovac, Serbia. Electronic address: milenkovic_sanja@yahoo.com.
  • Radovanovic Z; Innovation Centre of the Faculty of Technology and Metallurgy, Karnegijeva 4, University of Belgrade, Belgrade, Serbia. Electronic address: zradovanovic@tmf.bg.ac.rs.
  • Ilic B; Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11001 Belgrade, Serbia. Electronic address: bcetenovic@vin.bg.ac.rs.
  • Matovic B; Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11001 Belgrade, Serbia. Electronic address: mato@vin.bg.ac.rs.
  • Mihailovic R; Veterinary Specialist Institute "Kraljevo", Zicka 34, Kraljevo, Serbia. Electronic address: mihailovic@vsikv.com.
  • Zarubica A; Department of Chemistry, Faculty of Science and Mathematics, University of Nis, Visegradska 33, 18000 Nis, Serbia. Electronic address: zarubica2000@yahoo.com.
  • Zmejkoski D; Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11001 Belgrade, Serbia. Electronic address: danica@vin.bg.ac.rs.
  • Trickovic JF; Vinca Institute of Nuclear Sciences - National Institute of the Republic of Serbia, University of Belgrade, Mike Petrovica Alasa 12-14, 11001 Belgrade, Serbia. Electronic address: filipovicj@vin.bg.ac.rs.
Int J Biol Macromol ; 276(Pt 1): 133702, 2024 Sep.
Article en En | MEDLINE | ID: mdl-38972659
ABSTRACT
Bacterial cellulose (BC) is a promising natural polymer prized for its biocompatibility, microporosity, transparency, conformability, elasticity, and ability to maintain a moist wound environment while absorbing exudates. These attributes make BC an attractive material in biomedical applications, particularly in skin tissue repair. However, its lack of inherent antimicrobial activity limits its effectiveness. In this study, BC was enhanced by incorporating cerium (IV)-oxide (CeO2) nanoparticles, resulting in a series of bacterial cellulose-CeO2 (BC-CeO2) composite materials. Characterization via FESEM, XRD, and FTIR confirmed the successful synthesis of the composites. Notably, BC-CeO2-1 exhibited no cytotoxic or genotoxic effects on peripheral blood lymphocytes, and it additionally protected cells from genotoxic and cytotoxic effects in H2O2-treated cultures. Redox parameters in blood plasma samples displayed concentration and time-dependent trends in PAB and LPP assays. The incorporation of CeO2 nanoparticles also bolstered antimicrobial activity, expanding the potential biomedical applications of these composites.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Celulosa / Cerio / Hidrogeles / Nanopartículas / Antiinfecciosos / Antioxidantes Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Celulosa / Cerio / Hidrogeles / Nanopartículas / Antiinfecciosos / Antioxidantes Límite: Humans Idioma: En Revista: Int J Biol Macromol Año: 2024 Tipo del documento: Article Pais de publicación: Países Bajos