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RATIONALE: The ability to monitor the consequences of our actions for others is imperative for flexible and adaptive behavior, and allows us to act in a (pro)social manner. Yet, little is known about the neurochemical mechanisms underlying alterations in (pro)social performance monitoring. OBJECTIVE: The aim of this functional magnetic resonance imaging (fMRI) study was to improve our understanding of the role of dopamine and oxytocin and their potential overlap in the neural mechanisms underlying performance monitoring for own versus others' outcomes. METHOD: Using a double-blind placebo-controlled cross-over design, 30 healthy male volunteers were administered oxytocin (24 international units), the dopamine precursor L-DOPA (100 mg + 25 mg carbidopa), or placebo in three sessions. Participants performed a computerized cannon shooting game in two recipient conditions where mistakes resulted in negative monetary consequences for (1) oneself or (2) an anonymous other participant. RESULTS: Results indicated reduced error-correct differentiation in the ventral striatum after L-DOPA compared to placebo, independent of recipient. Hence, pharmacological manipulation of dopamine via L-DOPA modulated performance-monitoring activity in a brain region associated with reward prediction and processing in a domain-general manner. In contrast, oxytocin modulated the BOLD response in a recipient-specific manner, such that it specifically enhanced activity for errors that affected the other in the pregenual anterior cingulate cortex (pgACC), a region previously implicated in the processing of social rewards and prediction errors. Behaviorally, we also found reduced target sizes-indicative of better performance-after oxytocin, regardless of recipient. Moreover, after oxytocin lower target sizes specifically predicted higher pgACC activity when performing for others. CONCLUSIONS: These different behavioral and neural patterns after oxytocin compared to L-DOPA administration highlight a divergent role of each neurochemical in modulating the neural mechanisms underlying social performance monitoring.

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Stress has many consequences for our wellbeing, both physically and psychologically, underscoring the need to study markers of differential sensitivity to stressful situations. We examined associations between empathy and mentalizing abilities and psycho-physiological responses to a psychosocial stress task. We conducted two highly comparable studies, the first in men (N = 52) and the second in women (N = 72). Each study started with a self-report empathy measure and a mentalizing test [Reading the Mind in the Eyes Test (RMET)] followed by the Trier Social Stress Test (TSST) or a control task. Stress reactivity was confirmed in both men and women with significantly higher levels of cortisol, blood pressure, and subjective stress levels in response to the TSST compared to the control task. Higher accuracy on the RMET significantly predicted higher cortisol and heart rate reactivity, while self-reported empathic concern significantly predicted higher subjective stress reactivity. These associations were found in men, and when men and women were analyzed together. This indicates that higher levels of mentalizing and empathic abilities may confer sensitivity to socially stressful situations. While a moderation analysis indicated no gender differences in these associations, the findings could not be directly replicated in women. This suggests that gender may impact such associations and that replication of the findings in larger samples is warranted.

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Performing in a social context can result in negative feelings when our actions harm another person, but it can also lead to positive feelings when observing an opponent fail. The extent to which individuals scoring high on psychopathic traits, often characterized as self-centered with reduced concern for others' welfare, are sensitive to own and others' success and failure is yet unknown. However, knowledge about these processes is crucial for comprehending how these traits are involved in understanding ourselves and others during social interactions. In this functional magnetic resonance imaging (fMRI) study, healthy females scoring low or high on psychopathic traits performed a cannon-shooting game in non-social, cooperative, and competitive contexts. We hypothesized group differences regarding: (1) monitoring of own actions in a non-social context (errors that only negatively affect oneself) versus cooperative context (errors that also harm others), (2) successfully performing with either positive (shared gain) or negative consequences (selfish gain) for the co-player, and (3) observing other's performance leading to shared or selfish gain for oneself. Decreased performance-monitoring-related activations were found in posterior medial frontal cortex for females scoring high on psychopathic traits in the social versus non-social context. When observing others, striatal activations were stronger for selfish gains for high scorers and for shared gains for low scorers. The current outcomes demonstrate that performance-monitoring and reward-related brain activations importantly depend on the interplay between psychopathic traits and social context. We propose that these neural mechanisms may underlie the more self-centered behavior of individuals scoring high on psychopathic traits. As such, the current findings may open up new research avenues, which could advance our understanding of how personality traits impact performance monitoring in a wide variety of social contexts and could possibly lead to the development of interventions aimed at normalizing reduced concern for others.

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Disturbances in social cognitive processes such as the ability to infer others' mental states importantly contribute to social and functional impairments in psychiatric disorders. Yet, despite established social, emotional, and cognitive problems, the role of social cognition in obsessive-compulsive disorder is largely overlooked. The current review provides a first comprehensive overview of social (neuro)cognitive disturbances in adult patients with obsessive-compulsive disorder. Results of our review indicate various social cognitive alterations. Patients with obsessive-compulsive disorder show deficits in the recognition of affective social cues, specifically facial expressions of disgust, and more general deficits in theory of mind/mentalizing. Additionally, patients show heightened affective reactions and altered neural responding to emotions of self and others, as well as poor emotion regulation skills, which may contribute to poor social functioning of patients. However, the discrepancies in findings and scarcity of studies make it difficult to draw firm conclusions with regard to the specificity of social cognitive disturbances. The review offers directions for future research and highlights the need to investigate obsessive-compulsive disorder from an interactive social neurocognitive perspective in addition to the prevalent passive spectator perspective to advance our understanding of this intricate and burdensome disorder.

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Our mistakes often have negative consequences for ourselves, but may also harm the people around us. Continuous monitoring of our performance is therefore crucial for both our own and others' well-being. Here, we investigated how modulations in responsibility for other's harm affects electrophysiological correlates of performance-monitoring, viz. the error-related negativity (ERN) and error positivity (Pe). Healthy participants (N = 27) performed a novel social performance-monitoring paradigm in two responsibility contexts. Mistakes made in the harmful context resulted in a negative consequence for a co-actor, i.e., hearing a loud aversive sound, while errors in the non-harmful context were followed by a soft non-aversive sound. Although participants themselves did not receive auditory feedback in either context, they did experience harmful mistakes as more distressing and reported higher effort to perform well in the harmful context. ERN amplitudes were enhanced for harmful compared to non-harmful mistakes. Pe amplitudes were unaffected. The present study shows that performing in a potentially harmful social context amplifies early automatic performance-monitoring processes and increases the impact of the resulting harmful mistakes. These outcomes not only further our theoretical knowledge of social performance monitoring, but also demonstrate a novel and useful paradigm to investigate aberrant responsibility attitudes in various clinical populations.

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Aligning behavior in favor of group norms, i.e., social conformity, can help to successfully adapt to uncertain environments and may result in social approval. This may lead to enhanced feelings of belongingness and is found to be associated with reward-related activations in the brain. Individuals high on psychopathic traits violate group norms regularly. Yet, it is unclear how psychopathic traits are related to neural mechanisms involved in social conformity. This functional magnetic resonance imaging (fMRI) study includes 42 healthy females scoring low or high on the Psychopathic Personality Inventory questionnaire (PPI). Participants were asked to rate the trustworthiness of 120 faces while lying in the scanner. After rating each face, participants were presented with the group rating of European students. In an unanticipated second part participants rated all faces again, allowing us to focus on two main contrasts: (1) "Social conflict": group opinion in conflict with the participant's rating vs. group opinion aligned with participant rating; and (2) "Conformity": conflict trials followed by conformity vs. conflict trials followed by non-conformity. Behaviorally, the two groups showed similar conformity behavior. fMRI results showed that both groups activated the nucleus accumbens (NAc) following alignment, suggesting the central role of prediction errors and reward. The data also showed a significant interaction between group and conformity in the amygdala. Following conflicts, females scoring low on psychopathic traits showed a trend in enhanced amygdala activation for conformity relative to non-conformity. Additionally, results showed a trend significant group effect for non-conformity. Females scoring high on psychopathic traits showed more activation for non-conformity compared to females scoring low on psychopathic traits, suggesting altered emotional salience of experiencing conflict depending on psychopathic traits. Taken together, these results support the importance of investigating the role of relevant traits in adaptive behavior when facing uncertain social situations and the neural mechanisms involved in this process.

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This study investigated the stability of callous and unemotional (CU) traits across generations by assessing self-report assessments of psychopathy factors in parents and their relationship to children's CU traits in a clinical sample: 223 boys (M age = 7.65) and 83 girls (M = 7.35) referred for treatment of disruptive behavior disorders. First, we expanded previous findings showing a positive relationship between maternal psychopathy scores and CU traits in boys. Second, we tested whether parental psychopathy scores predicted CU traits in children over and above general indicators of mental health risk: parental psychopathology, parental warmth, and harsh parenting. Fathers' psychopathy factor 1 was uniquely related to CU traits. In contrast, the relationship between mothers' psychopathy factor 2 and children's CU traits disappeared when maternal warmth was included. Gender differences suggested these results are most applicable to boys. These findings support the intergenerational stability of psychopathy factor 1 between children and their fathers.

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Empathy plays a crucial role in healthy social functioning and in maintaining positive social relationships. In this study, 1250 children and adolescents (10-15 year olds) completed the newly developed Empathy Questionnaire for Children and Adolescents (EmQue-CA) that was tested on reliability, construct validity, convergent validity, and concurrent validity. The EmQue-CA aims to assess empathy using the following scales: affective empathy, cognitive empathy, and intention to comfort. A Principal Components Analysis, which was directly tested with a Confirmatory Factor Analysis, confirmed the proposed three-factor model resulting in 14 final items. Reliability analyses demonstrated high internal consistency of the scales. Furthermore, the scales showed high convergent validity, as they were positively correlated with related scales of the Interpersonal Reactivity Index (Davis, 1983). With regard to concurrent validity, higher empathy was related to more attention to others' emotions, higher friendship quality, less focus on own affective state, and lower levels of bullying behavior. Taken together, we show that the EmQue-CA is a reliable and valid instrument to measure empathy in typically developing children and adolescents aged 10 and older.

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Prior research suggests that adolescence is a time of enhanced sensitivity for practice and learning. In this study we tested the neural correlates of divergent thinking training in 15- to 16-year-old adolescents relative to an age-matched active control group. All participants performed an alternative uses task, a valid measure to test divergent thinking, while functional magnetic resonance imaging (fMRI) images were acquired before and after a training program. In between the 2 scanning sessions the experimental group completed 2 weeks of divergent thinking training (8 sessions) and the control group completed 2 weeks of rule switching training (8 session). A Group × Time interaction demonstrated stable divergent thinking performance for the experimental group, whereas in the control group performance declined. Generating alternative uses (experimental task condition) relative to generating ordinary characteristics of objects (control task condition) was associated with increased activation in the supramarginal gyrus (SMG), angular gyrus (AG), and middle temporal gyrus (MTG). Test-retest analyses showed that within-individuals-activation in these regions was stable over time in both groups. Changes in alternative uses fluency over time, however, were positively associated with changes in superior lateral PFC activation over time. Together, the results indicate that core brain regions for creativity (SMG, AG, and MTG) are consistently recruited in adolescence, and that changes in performance are associated with changes in activation in lateral PFC. (PsycINFO Database Record

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In this study we examined prosocial compensating behavior towards socially excluded ingroup and outgroup members by using a 'Prosocial Cyberball Game' in 9-17 year old Dutch adolescents (N = 133). Results showed that adolescents compensated for the social exclusion of an unknown peer in a virtual ball tossing game, by tossing the ball more often to that player in compensation conditions compared to the fair play condition. The proportion of tosses towards the excluded player did not significantly differ as a function of the group status of that player. Although compensating behavior towards ingroup versus outgroup members did not differ, the underlying motivation for this behavior may vary. More empathic concern was associated with more prosocial tosses towards an ingroup member, while more self-reported bullying behavior was associated with less compensating behavior in the outgroup condition. These findings may have practical implications for programs intending to change bystander behavior in bullying situations.

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The ability to perceive social intentions from people's eyes is present from an early age, yet little is known about whether this skill is fully developed in childhood or that subtle changes may still occur across adolescence. This fMRI study investigated the ability to read mental states by using an adapted version of the Reading the Mind in the Eyes task within adolescents (aged 12-19 years) over a 2-year test-retest interval. This longitudinal setup provides the opportunity to study both stability over time as well as age-related changes. The behavioral results showed that participants who performed well in the mental state condition at the first measurement also performed well at the second measurement. fMRI results revealed positive test-retest correlations of neural activity in the right superior temporal sulcus and right inferior frontal gyrus for the contrast mental state > control, suggesting stability within individuals over time. Besides stability of activation, dorsal medial prefrontal cortex showed a dip in mid-adolescence for the mental state > control condition and right inferior frontal gyrus decreased linearly with age for the mental state > control condition. These findings underline changes in the slope of the developmental pattern depending on age, even in the existence of relatively stable activation in the social brain network.

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This study examined neural correlates of empathy in adolescence while observing harmful acts. A total of 32 participants (aged 12-19 years) viewed pictures depicting negative (offenders inflicting intentional harm) and positive (friends socializing) social situations. After viewing each picture, participants could allocate hypothetical points to either the offender or the victim in a dictator game. Behaviorally, participants of all ages acted prosocially towards victims, fairly towards positive individuals and punishingly towards offenders. Brain imaging analyses showed that viewing negative situations was associated with more activation in the bilateral intraparietal lobule and the superior temporal sulcus (STS), whereas viewing positive situations was associated with more medial prefrontal cortex and left temporal parietal junction activity. Analyses testing for associations between brain activity and self-reported empathy showed that the STS was correlated negatively with reports of understanding others' distress and the willingness to help others. Together, the findings suggest that adolescents show similar prosocial behavior, as previously reported in adults with greater STS activity, when observing negative social acts that is modulated by an individual's empathy for others.

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Neurobiological models suggest that adolescents are driven by an overactive ventral striatum (VS) response to rewards that may lead to an adolescent increase in risk-taking behavior. However, empirical studies showed mixed findings of adolescents' brain response to rewards. In this study, we aimed to elucidate the relationship between reward-related brain activation and risky decision-making. In addition, we examined effects of age, puberty, and individuals' reward sensitivity. We collected two datasets: Experiment 1 reports cross-sectional brain data from 75 participants (ages 10-25) who played a risky decision task. Experiment 2 presents a longitudinal extension in which a subset of these adolescents (n=33) was measured again 2years later. Results showed that (1) a reward-related network including VS and medial PFC was consistently activated over time, (2) the propensity to choose the risky option was related to increased reward-related activation in VS and medial PFC, and (3) longitudinal comparisons indicated that self-reported reward sensitivity was specifically related to VS activation over time. Together, these results advance our insights in the brain circuitry underlying reward processing across adolescence.

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The Ultimatum Game (UG) is a valuable paradigm to study fairness considerations. Here, we tested developmental differences between altruistic and strategic motivations in fairness considerations using a version of the UG with hidden conditions. Participants were proposers and could divide coins between themselves and an anonymous other. Hidden information conditions involved division of coins where some coins were only visible to the participant (e.g., 8/2 condition where, from the total of 10 coins, 8 coins were visible to both players and 2 coins only visible to the proposer). In total, 22 young adults and 79 children between ages 8 and 13 played multiple one-shot versions of the UG with hidden conditions with anonymous others. Overall analyses confirmed validity of the task and showed that participants of all age groups had strategic intentions. Specific task analyses revealed that adults divided the coins equally in the standard UG conditions, but gave less to the second player in the hidden information conditions. The developmental comparisons revealed an age × condition interaction, such that adults and 10- to 12-year-old children differentiated between standard and hidden conditions more than 8- to 9-year-old children. These findings indicate that young children have a basic understanding of different strategic motives, but that behavior of adults and older children is driven more by strategic intentions.

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Risk taking is an integral part of learning and development, particularly during adolescence the prevalence of risky behaviors peak. It is hypothesized that the tendency to take risks is related to pubertal maturation, where there is interplay between gonadal hormones, the neural mechanisms that underlie affective (e.g., reward) processing, and risky behavior. To test this hypothesis, fifty healthy adolescents (aged 10-16 years; 33 girls, 17 boys) at different stages of puberty performed a gambling task while lying in the MRI scanner, and provided saliva samples for hormone assessment. Gonadal hormone levels were correlated with the neural response to receiving a monetary reward. Results showed that testosterone level correlated positively with activation in the striatum for both boys and girls, suggesting that individual differences in hormones at puberty are related to the way adolescents respond to reward, which can ultimately affect risk-taking behavior.

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