RESUMEN
As a common disease, cardiovascular and cerebrovascular diseases pose a great harm threat to human wellness. Even using advanced and comprehensive treatment methods, there is still a high mortality rate. Arteriosclerosis, as an important factor reflecting the severity of cardiovascular and cerebrovascular diseases, is imperative to detect the arteriosclerotic retinopathy. However, the detection of arteriosclerosis retinopathy requires expensive and time-consuming manual evaluation, while end-to-end deep learning detection methods also need interpretable design to high light task-related features. Considering the importance of automatic arteriosclerotic retinopathy grading, we propose a segmentation and classification interaction network (SCINet). We propose a segmentation and classification interaction architecture for grading arteriosclerotic retinopathy. After IterNet is used to segment retinal vessel from original fundus images, the backbone feature extractor roughly extracts features from the segmented and original fundus arteriosclerosis images and further enhances them through the vessel aware module. The last classifier module generates fundus arteriosclerosis grading results. Specifically, the vessel aware module is designed to highlight the important areal vessel features segmented from original images by attention mechanism, thereby achieving information interaction. The attention mechanism selectively learns the vessel features of segmentation region information under the proposed interactive architecture, which leads to reweighting the extracted features and enhances significant feature information. Extensive experiments have confirmed the effect of our model. SCINet has the best performance on the task of arteriosclerotic retinopathy grading. Additionally, the CNN method is scalable to similar tasks by incorporating segmented images as auxiliary information.
RESUMEN
BACKGROUND AND OBJECTIVE: Early fundus screening and timely treatment of ophthalmology diseases can effectively prevent blindness. Previous studies just focus on fundus images of single eye without utilizing the useful relevant information of the left and right eyes. While clinical ophthalmologists usually use binocular fundus images to help ocular disease diagnosis. Besides, previous works usually target only one ocular diseases at a time. Considering the importance of patient-level bilateral eye diagnosis and multi-label ophthalmic diseases classification, we propose a bilateral feature enhancement network (BFENet) to address the above two problems. METHODS: We propose a two-stream interactive CNN architecture for multi-label ophthalmic diseases classification with bilateral fundus images. Firstly, we design a feature enhancement module, which makes use of the interaction between bilateral fundus images to strengthen the extracted feature information. Specifically, attention mechanism is used to learn the interdependence between local and global information in the designed interactive architecture for two-stream, which leads to the reweighting of these features, and recover more details. In order to capture more disease characteristics, we further design a novel multiscale module, which enriches the feature maps by superimposing feature information of different resolutions images extracted through dilated convolution. RESULTS: In the off-site set, the Kappa, F1, AUC and Final score are 0.535, 0.892, 0.912 and 0.780, respectively. In the on-site set, the Kappa, F1, AUC and Final score are 0.513, 0.886, 0.903 and 0.767 respectively. Comparing with existing methods, BFENet achieves the best classification performance. CONCLUSIONS: Comprehensive experiments are conducted to demonstrate the effectiveness of this proposed model. Besides, our method can be extended to similar tasks where the correlation between different images is important.