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1.
J Pharm Sci ; 67(6): 752-6, 1978 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-660447

RESUMEN

Sensitive and specific spectrofluorometric assays were developed for the determination of d, 1-4-(3,4-dimethoxybenzyl)-2-imidazolidinone and d,1-4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone in blood and urine. Each compound is selectively extracted from buffered blood or urine and oxidized with alkaline permanganate to its respective fluorescent benzoic acid derivative, which is quantitated in acetic acid in ethanol (1:99). The method was applied to the determination of blood levels and urinary excretion in the dog following the administration of single intravenous and oral doses of each compound.


Asunto(s)
Imidazoles/análisis , Animales , Cromatografía en Capa Delgada , Perros , Imidazoles/sangre , Imidazoles/orina , Métodos , Espectrometría de Fluorescencia , Factores de Tiempo
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